A5088057424- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Blind Source Separation Techniques
- Autism Spectrum Disorder Research
- Radiopharmaceutical Chemistry and Applications
- Photoreceptor and optogenetics research
- Treatment of Major Depression
- Nuclear Materials and Properties
- Vitamin C and Antioxidants Research
- Mental Health Research Topics
- Fungal Infections and Studies
- Forensic Toxicology and Drug Analysis
- Analog and Mixed-Signal Circuit Design
- Epilepsy research and treatment
- Neurogenesis and neuroplasticity mechanisms
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Psychedelics and Drug Studies
- Genetics and Neurodevelopmental Disorders
- Bacterial Genetics and Biotechnology
- Neurological disorders and treatments
- Nuclear reactor physics and engineering
- Memory and Neural Mechanisms
Radboud University Nijmegen
2016-2022
Radboud University Medical Center
2016-2022
Medical University of Vienna
2022
Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie
2012-2017
The University of Melbourne
2011-2016
Université de Strasbourg
2012-2016
Inserm
2012-2016
The Royal Melbourne Hospital
2011-2016
University of California, Los Angeles
1999
University of Otago
1990
A single non-anaesthetic dose of ketamine, a non-competitive NMDA receptor (NMDAR) antagonist with hallucinogenic properties, induces cognitive impairment and psychosis, aggravates schizophrenia symptoms in patients. In conscious rats an equivalent ketamine key features animal models acute including hyperlocomotor activity, deficits prepulse inhibition gating auditory evoked potentials, concomitantly increases the power ongoing spontaneously occurring gamma (30-80 Hz) oscillations neocortex....
Abstract Sensory and cognitive deficits are common in schizophrenia. They associated with abnormal brain rhythms, including disturbances γ frequency (30–80 Hz) oscillations (GFO) cortex‐related networks. However, the underlying anatomofunctional mechanisms remain elusive. Clinical experimental evidence suggests that these result from a hyporegulation of glutamate N ‐methyl‐D‐aspartate receptors. Here we modeled rats ketamine, non‐competitive receptor antagonist translational psychotomimetic...
Noncompetitive N-methyl-d-aspartate receptor (NMDAr) antagonists can elicit many of the symptoms observed in schizophrenia healthy humans, and induce a behavioural phenotype animals relevant to psychosis. These compounds also elevate power synchrony gamma (γ) frequency (30–80 Hz) neural oscillations. Acute doses antipsychotic medications have been shown reduce ongoing γ inhibit NMDAr antagonist-mediated psychosis-like behaviour rodents. This study aimed investigate how chronic dosing regimen...
Emerging literature implicates abnormalities in gamma frequency oscillations the pathophysiology of schizophrenia, with hypofunction N-methyl-D-aspartate (NMDA) receptors implicated as a key factor. Prepulse inhibition (PPI) is behavioural measure sensorimotor gating, which disrupted schizophrenia. We studied relationships between ongoing and sensory-evoked PPI using pharmacological interventions designed to increase (ketamine, MK-801); reduce (LY379268); or disrupt (amphetamine). predicted...
The biogenesis of the polar flagellum Caulobacter crescentus is regulated by cell cycle as well a trans-acting regulatory hierarchy that functions to couple assembly gene expression. early flagellar structures (MS ring, switch, and flagellum-specific secretory system) required for transcription class III genes, which encode remainder basal body external hook structure. Similarly, gene-encoded expression IV flagellins, are incorporated into filament. Here, we demonstrate mutations in flbT,...
The non-competitive N-methyl d-aspartate glutamate receptor (NMDAR) antagonist ketamine elicits a brain state resembling high-risk states for developing psychosis and early stages of schizophrenia characterized by sensory cognitive deficits aberrant ongoing gamma (30-80 Hz) oscillations in cortical subcortical structures, including the thalamus. underlying mechanisms are unknown. goal present study was to determine whether ketamine-induced psychotic-relevant disturbs functional...
Background The Neuregulin 1 transmembrane domain heterozygous mutant (Nrg1 TM HET) mouse is used to investigate the role of Nrg1 in brain function and schizophrenia-like behavioural phenotypes. However, molecular alterations expression that underpin observations have been assumed, but not directly determined. Here we comprehensively characterise mRNA transcripts throughout development HET mouse. In addition, regulation high-frequency (gamma) electrophysiological oscillations this associate...
In prodromal and early schizophrenia, disorders of attention perception are associated with structural chemical brain abnormalities dysfunctional corticothalamic networks exhibiting disturbed rhythms. The underlying mechanisms elusive. non-competitive NMDA receptor antagonist ketamine simulates the symptoms including disturbances in ongoing task & sensory-related broadband beta-/gamma-frequency (17-29 Hz/30-80 Hz) oscillations networks. normal healthy subjects rodents, complex integration...
Summary: The effects of dextromethorphan (DM), a nonopioid antitussive and functional N ‐methyl‐ D‐aspartate (NMDA) antagonist, on expression development amygdaloid kindled seizures were examined. maximum anticonvulsant effect DM (30 mg/kg) fully appeared within 30 min administration lasted for at least 2 h. decreased, in dose‐dependent manner [10–70 mg/kg, intraperitoneally (i.p.)], the severity after injection, but estimated ED 50 was 3 times higher than previously reported value maximal...
Hyperthermia is a key clinical outcome from recreational use of MDMA and the leading cause related hospital admissions as well being linked to enhanced neurotoxicity [1, 2]. Animal models ischemia which also display hyperthermia have shown an inflammatory process mediated by microglia release proinflammatory cytokine interleukin 1(IL-1 ) play role in hyperthermicreactions [3]. Previous studies showed that prominently activated IL-1 levels increased following administration [4], lending...
Intravenous vitamin C (IVC, ascorbate [Asc]) and alpha-lipoic acid (ALA) are frequently coadministered in integrative oncology clinics, with limited understanding of combination effects or drug-drug interactions. As high-dose IVC has anticancer activity through peroxide (H
21 patients with metastatic breast cancer, refractory to conventional agents, were treated a combination of BCNU, vincristine, mitomycin-C and prednisone given every 4 weeks. Only three the nineteen (15.8%) evaluable observed have partial remission, whereas four experienced stabilization tumor. The sites which responded included skin lesions in two pleural effusion 1 patient. This resulted moderate severe thrombocytopenia five patients, but was otherwise well tolerated. pilot study therefore...
It is increasingly recognized that networks of brain areas work together to accomplish computational goals. However, functional connectivity are not often compared between different behavioral states and across frequencies electrical oscillatory signals. In addition, always defined as the strength signal relatedness two atlas-based anatomical locations. Here, we performed an exploratory analysis using data collected from high-density arrays in prefrontal cortex (PFC), striatum (STR), ventral...
Abstract Multiple distinct brain areas have been implicated in memory including the prefrontal cortex (PFC), striatum (STR), and ventral tegmental area (VTA). Information-exchange across these widespread networks requires flexible coordination at a fine time-scale. In present study, we collected high-density recordings from PFC, STR, VTA of male rats during baseline, encoding, consolidation, retrieval stages formation. Novel sub-regional clustering analyses identified patterns spatially...
ABSTRACT In prodromal and early schizophrenia, disorders of attention perception are associated with structural chemical brain abnormalities, dysfunctional corticothalamic networks exhibiting disturbed rhythms. The underlying mechanisms elusive. non-competitive NMDA receptor antagonist ketamine simulates the symptoms including disturbances in ongoing task & sensory-related broadband beta-/gamma-frequency (17-29 Hz/30-80 Hz) oscillations networks. normal healthy subjects rodents, complex...