A5079586758- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- GABA and Rice Research
- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Amyotrophic Lateral Sclerosis Research
- Sleep and Wakefulness Research
- Cholinesterase and Neurodegenerative Diseases
- Drug Transport and Resistance Mechanisms
- Diet, Metabolism, and Disease
- Prion Diseases and Protein Misfolding
Western Sydney University
2016-2025
Camden and Campbelltown Hospitals
2016-2024
UNSW Sydney
2012-2022
Neuroscience Research Australia
2013-2022
Schizophrenia Research Institute
2009-2019
Austrian Institute of Technology
2019
University of Salzburg
2019
Innsbruck Medical University
2019
Universität Innsbruck
2019
Paracelsus Medical University
2019
ATP-binding cassette transporter A7 (ABCA7) is expressed in the brain and has been detected macrophages, microglia, neurons. ABCA7 promotes efflux of lipids from cells to apolipoproteins can also regulate phagocytosis modulate processing amyloid precursor protein (APP) generate Alzheimer's disease (AD) amyloid-β (Aβ) peptide. Genome-wide association studies have indicated that single nucleotide polymorphisms confer increased risk for late-onset AD; however, role plays AD context unknown. In...
Cannabis contains over 70 unique compounds and its abuse is linked to an increased risk of developing schizophrenia. The behavioural profiles the psychotropic cannabis constituent Δ9-tetrahydrocannabinol (Δ9-THC) non-psychotomimetic cannabidiol (CBD) were investigated with a battery tests relevant anxiety positive, negative cognitive symptoms Male adult C57BL/6JArc mice given 21 daily intraperitoneal injections vehicle, Δ9-THC (0.3, 1, 3 or 10 mg/kg) CBD (1, 5, 50 mg/kg). produced classic...
Impairments in cognitive ability and widespread pathophysiological changes caused by neurotoxicity, neuroinflammation, oxidative damage, altered cholesterol homeostasis are associated with Alzheimer's disease (AD). Cannabidiol (CBD) has been show
Human genetic studies have shown that neuregulin 1 ( NRG1 ) is a potential susceptibility gene for schizophrenia. Nrg1 influences various neurodevelopmental processes, which are potentially related to The theory of schizophrenia suggests interactions between and environmental factors responsible biochemical alterations leading To investigate these match experimental design with the pathophysiology schizophrenia, we applied comprehensive behavioural phenotyping strategy motor activity,...
The abundantly expressed neuropeptide Y (NPY) plays an important role in anxiety and stress reactivity, as exogenous NPY administration reduces anxiety-like behaviour rodents. However, unlike the potent effects of seen pharmacological studies, two independent examinations a genetic mouse model for deficiency have shown only subtle, inconsistent task-dependent anxiety-related phenotypes male mutants. Here we present results newly developed germline NPY-knockout model, which has been...
Neuregulin 1 (Nrg1) has been widely recognized as a candidate gene for schizophrenia. This study therefore investigated mice heterozygous mutation in the transmembrane domain of this trophic factor (Nrg1+/− mice) number behavioural test systems with relevance to schizophrenia, including psychotropic drug-induced locomotor hyperactivity and prepulse inhibition (PPI) startle. Baseline activity open field or photocell cages was slightly, but significantly enhanced Nrg1+/− compared wild-type...
The cannabis constituent cannabidiol (CBD) possesses anxiolytic and antipsychotic properties. We have previously shown that transmembrane domain neuregulin 1 mutant (Nrg1 TM HET) mice display altered neurobehavioural responses to the main psychoactive of cannabis, Δ9-tetrahydrocannabinol. Here we investigated whether Nrg1 HET respond differently CBD reverses schizophrenia-related phenotypes expressed by these mice. Adult male wild type-like littermates (WT) received vehicle or (1, 50 100...
Abstract Heavy cannabis abuse increases the risk of developing schizophrenia. Adolescents appear particularly vulnerable to development psychosis-like symptoms after use. To test whether schizophrenia candidate gene neuregulin 1 (NRG1) modulates effects cannabinoids in adolescence, we tested male adolescent heterozygous transmembrane domain Nrg1 mutant (Nrg1 TM HET) mice and wild type-like littermates (WT) for their neurobehavioural response repeated Δ9-tetrahydrocannabinol (THC, 10 mg/kg...
Chronic stress and depression have adverse consequences on many organ systems, including the skeleton, but mechanisms underlying stress-induced bone loss remain unclear. Here we demonstrate that neuropeptide Y (NPY), centrally peripherally, plays a critical role in protecting against loss. Mice lacking anxiolytic factor NPY exhibit more anxious behavior elevated corticosterone levels. Additionally, following 6-week restraint, or cold-stress protocol, Npy-null mice three-fold greater compared...
Abstract Background Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting voluntary muscle movement as well cognitive and other behavioural domains at later stages. No effective treatment for ALS currently available. Elevated neuroinflammation, oxidative stress alterations to the endocannabinoid system are evident in ALS. The phytocannabinoid cannabidiol (CBD) has anti-inflammatory anti-oxidant properties. Thus, we evaluated remedial effects of chronic oral...
Cannabis increases the risk of schizophrenia in genetically vulnerable individuals. In this study we aim to show that susceptibility gene neuregulin 1 (Nrg1) modulates development tolerance cannabinoids mice. Nrg1 heterozygous (HET) and wild-type (WT) mice were treated daily for 15 d with synthetic analogue Δ9-tetrahydrocannabinol, CP55,940 (0.4 mg/kg). We measured impact exposure on locomotor activity, anxiety, prepulse inhibition (PPI), body temperature FosB/ΔFosB immunohistochemistry....
Abstract Excess caloric intake results in increased fat accumulation and an increase energy expenditure via diet-induced adaptive thermogenesis; however, the underlying mechanisms controlling these processes are unclear. Here we identify neuropeptide FF receptor-2 (NPFFR2) as a critical regulator of thermogenesis bone homoeostasis. Npffr2 −/− mice exhibit stronger phenotype when fed HFD display exacerbated obesity associated with failure activating brown adipose tissue (BAT) thermogenic...