A5019649133- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Cancer-related cognitive impairment studies
- Health, Medicine and Society
- Parkinson's Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Cellular transport and secretion
- Simulation-Based Education in Healthcare
- Cancer survivorship and care
- Musculoskeletal pain and rehabilitation
- Neuroscience and Neuropharmacology Research
- Lysosomal Storage Disorders Research
- Spine and Intervertebral Disc Pathology
- Innovations in Medical Education
- Health, Environment, Cognitive Aging
- Ginkgo biloba and Cashew Applications
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Technology Use by Older Adults
- Epilepsy research and treatment
- Surgical Simulation and Training
Assistance Publique – Hôpitaux de Paris
2019-2025
Université Paris Cité
2019-2025
Hôpital Fernand-Widal
2019-2025
Hôpital Lariboisière
2019-2025
Inserm
2019-2024
Sorbonne Paris Cité
2021-2024
Amyloidosis Foundation
2023
Optimisation Thérapeutique en Neuropsychopharmacologie
2022
Sorbonne Université
2019-2021
Centre National de la Recherche Scientifique
2019-2021
Glial fibrillary acidic protein (GFAP) is a marker of reactive astrogliosis that increases in the cerebrospinal fluid (CSF) and blood individuals with Alzheimer disease (AD). However, it not known whether there are differences GFAP levels across entire AD continuum its performance similar to CSF GFAP.To evaluate plasma throughout continuum, from preclinical dementia, compared GFAP.This observational, cross-sectional study collected data July 29, 2014, January 31, 2020, 3 centers. The...
Early biomarkers are needed to identify individuals at high risk of preclinical Alzheimer's disease and better understand the pathophysiological processes progression. Preclinical EEG changes would be non-invasive cheap screening tools could also help predict future progression clinical disease. However, impact amyloid-β deposition neurodegeneration on needs elucidated. We included participants from INSIGHT-preAD cohort, which is an ongoing single-centre multimodal observational study that...
<h3>Importance</h3> Plasma phosphorylated tau (p-tau) has proven to be an accurate biomarker for Alzheimer disease (AD) pathologic characteristics, offering a less expensive and invasive alternative cerebrospinal fluid (CSF) positron emission tomography biomarkers amyloid-β tau. comorbid characteristics are common associated with more rapid cognitive decline in patients dementia Lewy bodies (DLB); therefore, it is anticipated that plasma p-tau concentrations may have utility assessing...
Primary care is often the first point of contact for patients with cognitive complaints, making initial screening an essential step to avoid delays in diagnosing Alzheimer's disease (AD) at early stage. We developed MemScreen, a self-administered smartphone application that assesses overall cognition and verbal memory, evaluated its ability detect mild impairment (MCI) both general clinical populations. conducted two validation cohort studies: (1) UK-based Whitehall II study (13th wave,...
Background: Abnormalities in resting-state electroencephalogram (rsEEG) posterior alpha rhythm are promising biomarkers of neurodegenerative diseases (NDDs), often assessed via spectral analysis, ignoring the signal's non-rhythmic (aperiodic) component. Evidence assessing aperiodic and oscillatory rsEEG abnormalities across NDDs is scarce underpowered. Multicenter studies could tackle these limitations, but data pooling might introduce site-related differences (batch effects). This study...
Abstract Background Lumbar puncture (LP) is an invasive medical procedure that can be done by any doctor. Several simulation-based trainings have been built however the evaluations of theoretical knowledge and impact training never performed in real life. The objective was to evaluate a LP on improvement performance clinical practice. Methods Before after students’ training, confidence level were assessed. Over 6 months period, simulation evaluated success rate first carried out hospitalized...
Abstract Background Early biomarkers are needed to identify individuals at high risk of preclinical Alzheimer’s disease (AD) (Jack et al. , 2018). Electroencephalography (EEG) is a non‐invasive and cheap technique that would be an interesting screening tool for the stage AD. Method We included participants from INSIGHT‐preAD cohort, which ongoing single‐center multimodal observational study designed factors markers progression clinical AD in 318 cognitively normal aged 70–85 years with...
Background: Alpha-synuclein, abnormally aggregated in Dementia with Lewy Bodies (DLB), could represent a potential biomarker to improve the differentiation between DLB and Alzheimer’s disease (AD). Our main objective was compare Cerebrospinal Fluid (CSF) alpha-synuclein levels patients DLB, AD Neurological Control (NC) individuals. Methods: In monocentric retrospective study, we assessed CSF concentration validated ELISA kit (ADx EUROIMMUN) NC from tertiary memory clinic. Between-group...
Abstract Introduction Alzheimer’s disease (AD) is the most common cause of dementia. Non-invasive, affordable, and largely available biomarkers that are able to identify patients at a prodromal stage AD becoming essential, especially in context new disease-modifying therapies. Mild cognitive impairment (MCI) critical preceding dementia, but not all MCI will progress AD. This study explores potential non-invasive magnetoencephalography (MEG) predict future decline from Methods We analyzed...
Cerebrospinal fluid (CSF) biomarkers are core criteria for the diagnosis of Alzheimer's disease, as abnormalities in both amyloid-beta and pathologic tau required (Jack et al., 2018). Lumbar puncture (LP) is performed to collect CSF. To our knowledge, there no validated theoretical or practical training LP France. Our objectives were evaluate students' level, set up simulation-based this real conditions. work involved four stages : 1/ Evaluation knowledge regarding by Multiple Response...
Early biomarkers are needed to identify individuals at high risk of preclinical Alzheimer's disease (AD) (Sperling et al., 2011; Jack 2018). Electroencephalography (EEG) is a non-invasive and cheap technique that would be an interesting screening tool for the stage AD. However, most previous EEG studies have focused on later stages disease, after onset symptoms (Babiloni 2016). Our objective was We recruited 40 participants from INSIGHT-preAD cohort, which single-centre multimodal...
Abstract Background Early biomarkers are needed to identify individuals at high risk of preclinical Alzheimer’s disease (AD) (Jack et al. , 2018). Electroencephalography (EEG) is a non‐invasive and cheap technique that would be an interesting screening tool for the stage AD. Method We included participants from INSIGHT‐preAD cohort, which ongoing single‐center multimodal observational study designed factors markers progression clinical AD in 318 cognitively normal aged 70–85 years with...