A5024868777- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Health, Environment, Cognitive Aging
- Genetics, Aging, and Longevity in Model Organisms
- Neurobiology of Language and Bilingualism
- Developmental and Educational Neuropsychology
- Advanced Neuroimaging Techniques and Applications
- Telomeres, Telomerase, and Senescence
- Cerebrospinal fluid and hydrocephalus
- Neuroinflammation and Neurodegeneration Mechanisms
- Sleep and related disorders
- Cancer-related cognitive impairment studies
- Blood Pressure and Hypertension Studies
- Spatial Neglect and Hemispheric Dysfunction
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Bioinformatics and Genomic Networks
- Air Quality and Health Impacts
- Sleep and Wakefulness Research
- Cognitive Functions and Memory
- Medical Imaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Diet and metabolism studies
Pasqual Maragall Foundation
2016-2025
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2017-2025
Hospital Del Mar
2016-2025
Hospital del Mar Research Institute
2015-2025
Barcelonaβeta Brain Research Center
2016-2025
Instituto de Salud Carlos III
2022-2025
Municipal Institute for Medical Research
2012-2024
Brain (Germany)
2020-2024
German Center for Neurodegenerative Diseases
2024
Consejo Superior de Investigaciones Científicas
2024
Article10 November 2020Open Access Transparent process Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of preclinical Alzheimer's continuum when only subtle changes Aβ pathology are detected Marc Suárez-Calvet orcid.org/0000-0002-2993-569X Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain IMIM (Hospital del Mar Medical Institute), Servei de Neurologia, Hospital Mar, Centro Investigación Biomédica en Red sFragilidad...
Abstract Blood biomarkers indicating elevated amyloid-β (Aβ) pathology in preclinical Alzheimer’s disease are needed to facilitate the initial screening process of participants disease-modifying trials. Previous biofluid data suggest that phosphorylated tau231 (p-tau231) could indicate incipient Aβ pathology, but a comprehensive comparison with other putative blood is lacking. In ALFA+ cohort, all tested plasma (p-tau181, p-tau217, p-tau231, GFAP, NfL and Aβ42/40) were significantly changed...
Abstract Introduction The biological pathways involved in the preclinical stage of Alzheimer's continuum are not well understood. Methods We used NeuroToolKit and Elecsys ® immunoassays to measure cerebrospinal fluid (CSF) amyloid‐β (Aβ)42, Aβ40, phosphorylated tau (p‐tau), total (t‐tau), neurofilament light (NfL), neurogranin, sTREM2, YKL40, GFAP, IL6, S100, α‐synuclein cognitively unimpaired participants ALFA+ study, many within . Results CSF t‐tau, p‐tau, neurogranin increase throughout...
Radiation dose received by the neural stem cells of hippocampus during whole-brain radiotherapy has been associated with neurocognitive decline. The key concern using hippocampal avoidance-prophylactic cranial irradiation (HA-PCI) in patients small-cell lung cancer (SCLC) is incidence brain metastasis within avoidance zone.This phase III trial enrolled 150 SCLC (71.3% limited disease) to standard prophylactic (PCI; 25 Gy 10 fractions) or HA-PCI. primary objective was delayed free recall...
The Rey–Osterrieth complex figure (ROCF) and the free cued selective reminding test (FCSRT) are frequently used in clinical practice. ROCF assesses visual perception, constructional praxis, visuospatial memory, FCSRT verbal learning memory. As part of Spanish Normative Studies (NEURONORMA), we provide age- education-adjusted norms for (copy memory) FCSRT. sample consists 332 340 participants, respectively, who cognitively normal, community dwelling, ranging age from 50 to 94 years. Tables...
The preclinical phase of Alzheimer's disease (AD) is optimal for identifying early pathophysiological events and developing prevention programs, which are shared aims the ALFA project, including registry parent cohort nested ALFA+ study.The baseline visit included full cognitive evaluation, lifestyle habits questionnaires, DNA extraction, MRI. study adds wet imaging biomarkers deeper phenotyping.A total 2743 participants aged 45 to 74 years were in cohort. We show that this cohort, mostly...
Air quality might contribute to incidence of dementia-related disorders, including Alzheimer's dementia (AD). The aim our study is evaluate the effect urban environmental exposures (including exposure air pollution, noise and green space) on cognitive performance brain structure cognitively unimpaired individuals at risk for AD. ALFA (ALzheimer FAmilies) a prospective cohort middle-age, subjects, many them offspring AD patients. Cognitive was measured by administration episodic memory...
Abstract Introduction Apolipoprotein E ( APOE )‐ε4 is the major genetic risk factor for Alzheimer's disease. However, dose‐dependent impact of this allele on brain morphology healthy individuals remains unclear. Methods We analyzed gray matter volumes (GMvs) in a sample 533 middle‐aged with substantial representation ε4‐carriers (207 heterozygotes and 65 homozygotes). Results found ‐ε4 additive GMv reductions right hippocampus, caudate, precentral gyrus, cerebellar crus. In these regions,...
Abstract Background Mounting evidence links poor sleep quality with a higher risk of late-life dementia. However, the structural and cognitive correlates insomnia are still not well understood. The study aims were to characterize performance brain pattern cognitively unimpaired adults at increased for Alzheimer’s disease (AD) insomnia. Methods This cross-sectional included 1683 middle/late-middle-aged from ALFA (ALzheimer FAmilies) who underwent neuropsychological assessment, T1-weighted...
Subjective cognitive decline (SCD) consists of self-perceived in cognition over time. The occurrence specific additional features SCD (so-called SCDplus) confers a higher risk future decline. However, it is not known whether SCDplus patients have distinct and neuroimaging profile. Therefore, we aimed to study the associations between profiles population-based cohort. A total 2670 individuals from ALFA cohort underwent clinical, cognitive, MRI (n = 532) explorations. Subjects were classified...
<h3>Objective</h3> To develop and evaluate a model for staging cortical amyloid deposition using PET with high generalizability. <h3>Methods</h3> Three thousand twenty-seven individuals (1,763 cognitively unimpaired [CU], 658 impaired, 467 Alzheimer disease [AD] dementia, 111 non-AD 28 missing diagnosis) from 6 cohorts (European Medical Information Framework AD, Alzheimer9s Family, Biomarkers in Daily Practice, Amsterdam Dementia Cohort, Open Access Series of Imaging Studies [OASIS]-3,...
Air quality contributes to incidence of Alzheimer’s disease (AD) although the underlying neurobiological mechanisms are unclear. This study was aimed examine association between air pollution and concentrations cerebrospinal fluid (CSF) AD biomarkers amyloid-β (Aβ) deposition. Participants methods The sample included 156 cognitively unimpaired adults aged 57 years (61 at assessment) with increased risk from ALFA + Study. We examined CSF levels Aβ42, Aβ40, p-Tau, t-Tau, neurofilament light...
Abstract INTRODUCTION We studied how biomarkers of reactive astrogliosis mediate the pathogenic cascade in earliest Alzheimer's disease (AD) stages. METHODS performed path analysis on data from 384 cognitively unimpaired individuals ALzheimer and FAmilies (ALFA)+ study using structural equation modeling to quantify relationships between AD pathological cascade. RESULTS Cerebrospinal fluid (CSF) amyloid beta (Aβ) 42/40 was associated with Aβ aggregation positron emission tomography (PET) CSF...
The prevalence and impact of stressful life events (SLEs) on age-related Alzheimer disease (AD)-related pathways may depend social determinants including gender education. We investigated whether specific SLEs are associated with AD pathology neurodegeneration how these associations differ by This cross-sectional study included cognitively unimpaired participants, most a family history sporadic AD, from the ALzheimer's FAmilies (ALFA) cohort, based in Barcelona, Spain. Participants had...
The recent prospect of pharmaceutical interventions for cognitive impairment Down syndrome(DS) has boosted a number clinical trials in this population. However, running the raised some methodological challenges and questioned prevailing methodology used to evaluate functioning DS individuals. This is usually achieved by comparing individuals matched healthy controls same mental age. We propose new tool, TESDAD Battery that uses comparison with age-matched typically developed adults. an...
Abstract White matter hyperintensities (WMH) are commonly detected in the brain of elderly individuals and have been associated with a negative impact on multiple cognitive domains. We aim to investigate global regional distribution WMH episodic memory executive function middle-aged cognitively unimpaired participants [ N = 561 (45–75 years)] enriched for Alzheimer’s disease risk factors. were automatically segmented from FLAIR, T1 FSE MR images. load was calculated both globally regionally....
Perivascular spaces (PVS) have an important role in the elimination of metabolic waste from brain. It has been hypothesized that enlargement PVS (ePVS) could be affected by pathophysiological mechanisms involved Alzheimer's disease (AD), such as abnormal levels CSF biomarkers. However, relationship between ePVS and these remains unknown.We aimed to investigate association biomarkers several for AD. We will associated early AD continuum (i.e., amyloid positive cognitively unimpaired...
<h2>Summary</h2><h3>Background</h3> Neuroimaging-based brain-age delta has been shown to be a mediator linking cardiovascular risk factors cognitive function. We aimed assess the mediating role of in association between modifiable dementia and longitudinal decline middle-aged older individuals who are asymptomatic, stratified by Alzheimer's disease pathology. also explored whether mediation effect is specific domain. <h3>Methods</h3> In this cohort study, we included participants from ALFA+...
Objective Along with the known effects of stress on brain structure and inflammatory processes, increasing evidence suggest a role chronic in pathogenesis Alzheimer's disease (AD). We investigated association accumulated stressful life events (SLEs) AD pathologies, neuroinflammation, gray matter (GM) volume among cognitively unimpaired (CU) individuals at heightened risk AD. Methods This cross‐sectional cohort study included 1,290 CU participants (aged 48–77) from ALFA SLE, lumbar puncture...