A5098947956- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- GDF15 and Related Biomarkers
- Medical Imaging Techniques and Applications
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Tryptophan and brain disorders
- EEG and Brain-Computer Interfaces
- Genetics, Aging, and Longevity in Model Organisms
- Blood Pressure and Hypertension Studies
- Long-Term Effects of COVID-19
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Biomarkers in Disease Mechanisms
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Connexins and lens biology
- Heart Rate Variability and Autonomic Control
- Spatial Neglect and Hemispheric Dysfunction
Roche (Switzerland)
2024-2025
Roche Pharma AG (Germany)
2024-2025
The prevalence and impact of stressful life events (SLEs) on age-related Alzheimer disease (AD)-related pathways may depend social determinants including gender education. We investigated whether specific SLEs are associated with AD pathology neurodegeneration how these associations differ by This cross-sectional study included cognitively unimpaired participants, most a family history sporadic AD, from the ALzheimer's FAmilies (ALFA) cohort, based in Barcelona, Spain. Participants had...
Studies suggest that cerebrospinal fluid (CSF) levels of amyloid-β (Aβ)42 and Aβ40 present a circadian rhythm. However sustained sampling large volumes CSF with indwelling intrathecal catheters used in most these studies might have affected dynamics thereby confounded the observed fluctuations biomarker levels.
Abstract INTRODUCTION Identifying the link between early Alzheimer's disease (AD) pathological changes and neurodegeneration in asymptomatic individuals may lead to discovery of preventive strategies. We assessed longitudinal brain atrophy cognitive decline as a function cerebrospinal fluid (CSF) AD biomarkers two independent cohorts cognitively unimpaired (CU) individuals. METHODS used voxel‐based morphometry (VBM) combination with hippocampal subfield segmentation. Changes neuroimaging...
Abstract INTRODUCTION This study examined the association of longitudinal atrophy with baseline cerebrospinal fluid (CSF) amyloid beta (Aβ, A) and phosphorylated tau (p‐tau, T) biomarkers (Aβ42/40, p‐tau181) in 406 cognitively unimpaired (CU) individuals (6.670 years follow‐up on average, up to 13 imaging visits) assess whether A+ is associated Alzheimer's disease–like this depends p‐tau181 levels. METHODS An A‐T‐ CU group free from abnormal neurodegeneration (N) was identified using a...
INTRODUCTION: While hallmarked by the accumulation of β-amyloid plaques (Aβ) and neurofibrillary tangles (tau) in brain, Alzheimer′s disease (AD) is a multifactorial disorder that involves additional pathological events, including neuroinflammation, neurodegeneration synaptic dysfunction. AD-associated biomolecular changes seem to be attenuated carriers functionally advantageous variant KLOTHO gene (KL-VS HET ). Independently, better cardiorespiratory fitness (CRF) associated with health...
Abstract INTRODUCTION Elevated cardiovascular rate pressure product (RPP) has been shown to predict mortality and is associated with poor cognitive test performance among older adults. However, it unclear how RPP related the cerebrospinal fluid (CSF) biomarkers of neurodegeneration neuroinflammation. METHODS was cross‐sectionally evaluated as a predictor CSF biomarker levels in cohort 310 cognitively unimpaired late‐middle‐aged adults at risk for Alzheimer's disease. The primary outcomes...
The lack of cognitive awareness, anosognosia, is a clinical deficit in Alzheimer's disease (AD) dementia. However, an increased awareness function, hypernosognosia, may serve as marker the preclinical stage. Subjective decline (SCD) might correspond to initial symptom dynamic trajectory but SCD be absent along with low actual performance We hypothesized that distinct meta-cognitive profiles, both hypernosognosia and identified preclinical-AD. This research evaluated association between...
Abstract INTRODUCTION We examined whether the aging suppressor KLOTHO gene's functionally advantageous KL‐VS variant (KL‐VS heterozygosity [KL‐VS HET ]) confers resilience against deleterious effects of indexed by cerebrospinal fluid (CSF) biomarkers neuroinflammation (interleukin‐6 [IL‐6], S100 calcium‐binding protein B [S100B], triggering receptor expressed on myeloid cells [sTREM2], chitinase‐3‐like 1 [YKL‐40], glial fibrillary acidic [GFAP]), neurodegeneration (total α‐synuclein [α‐Syn],...
Abstract INTRODUCTION Cerebral blood flow (CBF) is reduced in cognitively impaired (CI) Alzheimer's disease (AD) patients. We checked the sensitivity of time‐encoded arterial spin labeling (te‐ASL) measuring CBF alterations individuals with positive AD biomarkers and associations relevant unimpaired (CU) individuals. METHODS compared te‐ASL single‐postlabel delay (PLD) ASL 59 adults across continuum, classified as CU amyloid beta (Aβ) negative (−), Aβ (+), CI Aβ+. sought AD, cerebrovascular...
Abstract INTRODUCTION We examined whether baseline glial markers soluble triggering receptor expressed on myeloid cell 2 (sTREM2), chitinase 3‐like protein 1 (YKL‐40), and fibrillary acidic (GFAP) in cerebrospinal fluid (CSF), plasma GFAP are associated with cognitive change cognitively unimpaired (CU) individuals at risk of Alzheimer's disease (AD). METHODS A total 353 CU (mean age 60.9 years) participants were included follow‐up time 3.28 years). Linear regression models cognition as...
Glial reactivity may contribute to sex/gender differences in Alzheimer's disease (AD) pathophysiology. Here, we investigated the differential effect of cerebrospinal fluid (CSF) glial markers on AD pathology and neurodegeneration by among cognitively unimpaired older adults at increased risk developing AD. We included 397 participants from ALFA+ cohort with CSF Aβ
Cerebrospinal fluid (CSF) biomarkers of synaptic dysfunction, neuroinflammation, and glial response, complementing Alzheimer's disease (AD) core biomarkers, have improved the pathophysiological characterization disease. Here, we tested hypothesis that co-expression multiple CSF will help identification AD-like phenotypes when biomarker positivity thresholds are not met yet. Two hundred seventy cognitively unimpaired adults with family history (FH) sporadic AD (mean age = 60.6 ± 4.85 years,...
Abstract Background A growing body of research links environmental factors with neurodegeneration and premature mortality. However, the biological mechanisms through which pollutants affect early Alzheimer’s disease (AD) pathology in asymptomatic stages are largely unknown. We aimed to assess association between air pollution changes cerebrospinal fluid (CSF) biomarkers AD neuroinflammatory processes cognitively unimpaired (CU) individuals at risk dementia. Method included 225 middle-aged CU...
Klotho, encoded by the
Abstract Background Cerebral pulsatility (PI) is reportedly higher in individuals with AD and MCI compared to age matched controls has been associated greater beta‐amyloid (Aß) burden, but its relationship other neurodegenerative biomarkers unknown. Higher cardiorespiratory fitness (CRF) positively affects vascular function lower PI several large cerebral vessels. The between PI, CRF, for neurodegeneration have not yet characterized. Our objective was examine a potential CRF modification of...
Abstract Background Increasing evidence supports the notion that vascular dysfunction contributes to evolution of Alzheimer’s disease (AD). Cerebral pulsatility index (PI) is reportedly higher in AD and MCI compared age matched controls has been associated with greater beta‐amyloid (Aß) burden. Higher cardiorespiratory fitness (CRF) positively affects function lower PI several large cerebral vessels. Our objective was examine whether CRF modifies relationship between PI, Aß burden, core...
Abstract Background Alzheimer disease (AD) plasma biomarkers change in the preclinical stage of AD. However, robustness discrimination performance these biomarkers, as well their association with longitudinal primary pathology (amyloid and tau) changes, is less understood. We aimed to determine ability baseline amyloid‐β (Aβ)42/40, p‐tau181, GFAP NfL detect CU individuals at risk Method Plasma were measured using NeuroToolKit (NTK), a panel robust prototype biomarker assays (Roche...
Abstract Background Alzheimer's disease (AD) is identified by the accumulation of amyloid β (Aβ) and tau proteins in brain. The NeuroToolKit offers automated cerebrospinal fluid (CSF) immunoassays core AD biomarkers neurodegeneration synaptic function, including neurofilament light (NfL), SNAP‐25, neuronal pentraxin 2 (NPTX2). This work explores whether these three markers predict pre‐dementia cognitive decline synergistically with or after accounting for CSF ptau 181 /Aβ 42 . Method...
Abstract Background The driving mechanisms of structural brain alterations in the earliest stages Alzheimer's disease (AD) are not well understood. Previous heterogeneous findings preclinical AD, including subtle atrophy and also increased grey matter (GM) volume, underscore need for further exploration. This study uses an extensive fluid biomarkers panel to identify pathological drivers behind longitudinal GM changes cognitively unimpaired (CU) adults. Method We investigated 632 CU...
Abstract Background Arterial spin labelling (ASL) is a non‐invasive MRI technique for quantifying cerebral blood flow (CBF), used monitoring changes over the course of disease or treatment. A crucial parameter in ASL post‐labelling delay (PLD), determined by time it takes to travel from labeling location tissue under investigation. Time‐encoded (te‐ASL) utilizes multiple PLDs more accurate quantification. This study aims enhance our understanding CBF across AD continuum, emphasizing utility...
Abstract Background Obstructive sleep apnea (OSA) is associated with hypoxia‐induced neuronal impairment and dysfunction—key risk factors for the pathogeneses of age‐related neurodegenerative diseases such as Alzheimer‘s disease (AD). This study examined longitudinal associations between OSA severity CSF biomarkers AD, synaptic dysfunction, neuroinflammation in a sample late‐middle‐aged adults increased AD. Method N=25 cognitively unimpaired (64% female, mean age 65.8 ± 7.1 years, 42.3%...
Abstract Background Fluid biomarkers provide a convenient way to predict AD pathophysiology. However, few studies have focused on determining associations with tau neurofibrillary tangle pathology in the early preclinical continuum, relevant prevention strategies. Methods Ninety‐nine cognitively unimpaired individuals from ALFA+ cohort valid 18 F‐RO‐948 and F‐flutemetamol PET, T1‐weighted MRI, cognition, CSF, plasma were included. Participants initially categorized into AT stages using...