A5028952569- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 and Mental Health
- Intensive Care Unit Cognitive Disorders
- Stress Responses and Cortisol
- Sleep and related disorders
- Long-Term Effects of COVID-19
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Mental Health and Patient Involvement
- S100 Proteins and Annexins
- Traumatic Brain Injury Research
- Transcranial Magnetic Stimulation Studies
- Aging and Gerontology Research
- Effects of Vibration on Health
- Neurological Disease Mechanisms and Treatments
- Health, psychology, and well-being
- Inflammation biomarkers and pathways
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Health disparities and outcomes
- Posttraumatic Stress Disorder Research
- Resilience and Mental Health
Barcelona Institute for Global Health
2024-2025
Barcelonaβeta Brain Research Center
2022-2025
Universitat Pompeu Fabra
2022-2025
Pasqual Maragall Foundation
2022-2024
John Wiley & Sons (United States)
2024
Hudson Institute
2024
Hospital del Mar Research Institute
2023
Hospital Del Mar
2023
Municipal Institute for Medical Research
2023
University College London
2021
The prevalence and impact of stressful life events (SLEs) on age-related Alzheimer disease (AD)-related pathways may depend social determinants including gender education. We investigated whether specific SLEs are associated with AD pathology neurodegeneration how these associations differ by This cross-sectional study included cognitively unimpaired participants, most a family history sporadic AD, from the ALzheimer's FAmilies (ALFA) cohort, based in Barcelona, Spain. Participants had...
Objective Along with the known effects of stress on brain structure and inflammatory processes, increasing evidence suggest a role chronic in pathogenesis Alzheimer's disease (AD). We investigated association accumulated stressful life events (SLEs) AD pathologies, neuroinflammation, gray matter (GM) volume among cognitively unimpaired (CU) individuals at heightened risk AD. Methods This cross‐sectional cohort study included 1,290 CU participants (aged 48–77) from ALFA SLE, lumbar puncture...
Few longitudinal studies have explored the association between apolipoprotein E gene (APOE) status, sleep disturbances, and incident dementia among middle-aged participants.Cox regression analyses of duration, insomnia, daytime napping with all-cause their interaction APOE genetic risk 397,777 adults.During a median 10.8 years follow-up, sleeping more or fewer than 7 hours was associated higher (hazard ratio [HR] for 5 vs hours: 1.35, 95% confidence interval [CI] 1.11-1.64; HR 9 1.59; CI...
Abstract INTRODUCTION We examined whether baseline glial markers soluble triggering receptor expressed on myeloid cell 2 (sTREM2), chitinase 3‐like protein 1 (YKL‐40), and fibrillary acidic (GFAP) in cerebrospinal fluid (CSF), plasma GFAP are associated with cognitive change cognitively unimpaired (CU) individuals at risk of Alzheimer's disease (AD). METHODS A total 353 CU (mean age 60.9 years) participants were included follow‐up time 3.28 years). Linear regression models cognition as...
The investigation of resting-state functional connectivity (rsFC) in asymptomatic individuals at genetic risk for Alzheimer's disease (AD) enables discovering the earliest brain alterations preclinical stages disease. APOE-ε4 variant is major factor AD, and previous studies have reported rsFC abnormalities carriers ε4 allele. Yet, no study has assessed gene-dose effects on measures, only a few included measures cognitive performance to aid clinical interpretation. We impact sample 429...
Abstract Background The COVID-19 pandemic may worsen the mental health of people reporting subjective cognitive decline (SCD) and therefore their clinical prognosis. We aimed to investigate association between intensity SCD anxious/depressive symptoms during confinement underlying mechanisms. Methods Two hundred fifty cognitively unimpaired participants completed Hospital Anxiety Depression Scale (HADS) SCD-Questionnaire (SCD-Q) underwent amyloid-β positron emission tomography imaging with [...
Glial reactivity may contribute to sex/gender differences in Alzheimer's disease (AD) pathophysiology. Here, we investigated the differential effect of cerebrospinal fluid (CSF) glial markers on AD pathology and neurodegeneration by among cognitively unimpaired older adults at increased risk developing AD. We included 397 participants from ALFA+ cohort with CSF Aβ
Cerebrospinal fluid (CSF) biomarkers of synaptic dysfunction, neuroinflammation, and glial response, complementing Alzheimer's disease (AD) core biomarkers, have improved the pathophysiological characterization disease. Here, we tested hypothesis that co-expression multiple CSF will help identification AD-like phenotypes when biomarker positivity thresholds are not met yet. Two hundred seventy cognitively unimpaired adults with family history (FH) sporadic AD (mean age = 60.6 ± 4.85 years,...
Abstract Background Cognitive resilience can be defined as better‐than‐expected cognitive performance in the context of Alzheimer’s disease (AD) pathologies or increased AD risk. We investigated pathways associated with trajectories amyloid positive (A+) and/or APOE4 cognitively unimpaired (CU) older adults including brain resilience, resistance to and vascular pathology. Method included 534 CU ADNI participants available data, longitudinal amyloid‐PET ( [ 18 F]florbetaben F]florbetapir)...
Abstract Background Women show greater atrophy in medial temporal lobe (MTL) compared to men, irrespective of amyloid burden. We examined whether depressive symptoms, which are more prevalent women and also linked MTL atrophy, interact with tau accumulation on trajectories across 7 years differently among men women. Method included 71 non‐demented ADNI participants available baseline data symptoms (Geriatric Depression Scale; GDS), (AV1451 PET BRAAK I/II SUVR [entorhinal hippocampus]),...
Abstract Background Stress is associated with adverse health outcomes, but the pathways through which stressful life events affect brain health, and age periods most vulnerable to these effects, are unknown. We investigated questions in relation Alzheimer’s disease (AD) pathophysiology integrity cognitively unimpaired participants at risk for AD. Method In this cross‐sectional cohort study, 1168 completed 18‐item Elder’s Life Inventory measuring occurrence (and occurrence) of events. Of...
Abstract Background Medial temporal lobe structures are particularly vulnerable in age‐related neurodegenerative diseases. Here, we investigated the brain reorganization that allows maintaining relatively normal global cognitive functioning patients with herpes simplex encephalitis (HSE) – an infectious neurological disease ‐ marked focal atrophy most pronounced medial lobes, hippocampus. Using rs‐fMRI (i) characterized patterns of functional network organization, and (ii) compared...
Abstract Background Cognitively unimpaired (CU) adults with Alzheimer’s disease (AD) pathologic change may be more vulnerable to developing neuropsychiatric symptoms. We reported an association of higher β‐amyloid (Aβ) and increased anxiety/depression during the COVID‐19 lockdown in CU (Akinci et al., 2022). Here, we investigated whether changes Aβ 1−42 predict post‐traumatic stress disorder (PTSD) symptomatology following at risk for AD. Method included 128 participants who underwent lumbar...
Abstract Background COVID‐19‐related SARS‐CoV‐2 infection has been linked with brain abnormalities and cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD), neuroinflammation, neuronal injury. Whether COVID‐19 increases the brain’s vulnerability to development AD is unclear. In participants at an increased risk AD, we investigated association pre‐ post‐pandemic biomarkers. Method We included 132 cognitively unimpaired adults from ALFA+ cohort (52‐71 years, 61.4% women) who...
Abstract Background Previous studies reported sleep alterations during the COVID‐19 lockdown. Disrupted may influence and promote Alzheimer’s disease (AD) pathologies. In cognitively unimpaired adults at AD risk, we investigated association of duration changes lockdown in relation to pre‐ post‐lockdown AD‐related CSF biomarkers. Method We included 118 (52‐71 years, 61.9% women) with self‐reported data on before (May–July 2020). Participants completed a questionnaire hours per night (<7h...
Abstract Background Sex‐specific vulnerability and resilience along the amyloid cascade may be partly explained by neuroinflammatory processes. Microglial activation play a more important role in development of Alzheimer’s disease (AD) women than men. We investigated effect sex biomarkers microglia astrocytic on (A) tau (T) burden, neurodegeneration (N) cognitively unimpaired (CU) older adults at increased AD risk. Method included 397 CU participants (49‐73 years, 61.5% women) with following...
Abstract Background In preclinical Alzheimer’s disease (AD), previous evidence suggests that glial reactivity may affect cognitive performance. This study aimed to test whether markers cerebrospinal fluid (CSF) GFAP, YKL‐40, sTREM2, and plasma GFAP are associated with change in cognitively unimpaired individuals at risk of AD. We hypothesized higher levels be better outcomes. Method included 353 from the ALFA+ cohort available baseline (BL) biomarkers cognition follow‐up (FU) 3 years later...
Abstract Background Anxious depressive symptomatology and stress are associated with cognitive decline. Recent evidence suggests a relation between these factors Alzheimer’s disease (AD) pathophysiology early in the continuum. With current increases anxiety, depression due to Covid19 pandemic ‐ notably women unrevealing biological mechanisms underlying associations sex/gender approach appears fundamental. Method We included total of 1170 participants series observational cohort studies....
Abstract Background Physical activity (PA) has a beneficial effect on brain health in older age. Whether and how changes PA during midlife are linked to later life remains understudied. In adults at risk for Alzheimer’s disease (AD), we investigated the change relation biomarkers of AD pathology, microglia, integrity. Methods A questionnaire investigating minutes per week was administered 273 cognitively unimpaired participants baseline after follow‐up 4.1 (±0.8) years. The minutes/week...