A5002251338- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
- Stress Responses and Cortisol
- Cancer-related cognitive impairment studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Health, Environment, Cognitive Aging
- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- Intensive Care Unit Cognitive Disorders
- Advanced Neuroimaging Techniques and Applications
- Acne and Rosacea Treatments and Effects
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Parasitic infections in humans and animals
- MRI in cancer diagnosis
- Aging and Gerontology Research
- Urological Disorders and Treatments
- Balance, Gait, and Falls Prevention
- Infectious Encephalopathies and Encephalitis
- Cerebrovascular and Carotid Artery Diseases
- S100 Proteins and Annexins
- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
Barcelona Institute for Global Health
2024-2025
Barcelonaβeta Brain Research Center
2021-2025
Universitat Pompeu Fabra
2021-2025
Pasqual Maragall Foundation
2021-2024
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2024
John Wiley & Sons (United States)
2024
Hudson Institute
2024
Hospital del Mar Research Institute
2023
Hospital Del Mar
2022-2023
Municipal Institute for Medical Research
2023
The prevalence and impact of stressful life events (SLEs) on age-related Alzheimer disease (AD)-related pathways may depend social determinants including gender education. We investigated whether specific SLEs are associated with AD pathology neurodegeneration how these associations differ by This cross-sectional study included cognitively unimpaired participants, most a family history sporadic AD, from the ALzheimer's FAmilies (ALFA) cohort, based in Barcelona, Spain. Participants had...
<h2>Summary</h2><h3>Background</h3> Neuroimaging-based brain-age delta has been shown to be a mediator linking cardiovascular risk factors cognitive function. We aimed assess the mediating role of in association between modifiable dementia and longitudinal decline middle-aged older individuals who are asymptomatic, stratified by Alzheimer's disease pathology. also explored whether mediation effect is specific domain. <h3>Methods</h3> In this cohort study, we included participants from ALFA+...
Objective Along with the known effects of stress on brain structure and inflammatory processes, increasing evidence suggest a role chronic in pathogenesis Alzheimer's disease (AD). We investigated association accumulated stressful life events (SLEs) AD pathologies, neuroinflammation, gray matter (GM) volume among cognitively unimpaired (CU) individuals at heightened risk AD. Methods This cross‐sectional cohort study included 1,290 CU participants (aged 48–77) from ALFA SLE, lumbar puncture...
Abstract Telomere length (TL) is associated with biological aging, consequently influencing the risk of age-related diseases such as Alzheimer’s disease (AD). We aimed to evaluate potential causal role TL in AD endophenotypes (i.e . , cognitive performance, N = 2233; brain age and AD-related signatures, 1134; cerebrospinal fluid biomarkers (CSF) neurodegeneration, 304) through a Mendelian randomization (MR) analysis. Our analysis was conducted context ALFA (ALzheimer FAmilies) study,...
The investigation of resting-state functional connectivity (rsFC) in asymptomatic individuals at genetic risk for Alzheimer's disease (AD) enables discovering the earliest brain alterations preclinical stages disease. APOE-ε4 variant is major factor AD, and previous studies have reported rsFC abnormalities carriers ε4 allele. Yet, no study has assessed gene-dose effects on measures, only a few included measures cognitive performance to aid clinical interpretation. We impact sample 429...
Abstract Background The COVID-19 pandemic may worsen the mental health of people reporting subjective cognitive decline (SCD) and therefore their clinical prognosis. We aimed to investigate association between intensity SCD anxious/depressive symptoms during confinement underlying mechanisms. Methods Two hundred fifty cognitively unimpaired participants completed Hospital Anxiety Depression Scale (HADS) SCD-Questionnaire (SCD-Q) underwent amyloid-β positron emission tomography imaging with [...
Glial reactivity may contribute to sex/gender differences in Alzheimer's disease (AD) pathophysiology. Here, we investigated the differential effect of cerebrospinal fluid (CSF) glial markers on AD pathology and neurodegeneration by among cognitively unimpaired older adults at increased risk developing AD. We included 397 participants from ALFA+ cohort with CSF Aβ
Cerebrospinal fluid (CSF) biomarkers of synaptic dysfunction, neuroinflammation, and glial response, complementing Alzheimer's disease (AD) core biomarkers, have improved the pathophysiological characterization disease. Here, we tested hypothesis that co-expression multiple CSF will help identification AD-like phenotypes when biomarker positivity thresholds are not met yet. Two hundred seventy cognitively unimpaired adults with family history (FH) sporadic AD (mean age = 60.6 ± 4.85 years,...
Increased anxious-depressive symptomatology is observed in the preclinical stage of Alzheimer disease (AD), which may accelerate progression. We investigated whether β-amyloid, cortical thickness medial temporal lobe structures, neuroinflammation, and sociodemographic factors were associated with greater symptoms during COVID-19 confinement.This retrospective observational study included cognitively unimpaired older adults from Alzheimer's Families cohort, majority a family history sporadic...
The mechanisms driving primary progressive and relapsing-remitting multiple sclerosis (PPMS/RRMS) phenotypes are unknown. Magnetic resonance imaging (MRI) studies support the involvement of gray matter (GM) in degeneration, highlighting its damage as an early feature both phenotypes. However, role GM microstructure is unclear, calling for new methods decryption.To investigate morphometric microstructural differences between PPMS RRMS to characterize tissue degeneration using MRI.Prospective...
Abstract Background Cognitive resilience can be defined as better‐than‐expected cognitive performance in the context of Alzheimer’s disease (AD) pathologies or increased AD risk. We investigated pathways associated with trajectories amyloid positive (A+) and/or APOE4 cognitively unimpaired (CU) older adults including brain resilience, resistance to and vascular pathology. Method included 534 CU ADNI participants available data, longitudinal amyloid‐PET ( [ 18 F]florbetaben F]florbetapir)...
Abstract Background Women show greater atrophy in medial temporal lobe (MTL) compared to men, irrespective of amyloid burden. We examined whether depressive symptoms, which are more prevalent women and also linked MTL atrophy, interact with tau accumulation on trajectories across 7 years differently among men women. Method included 71 non‐demented ADNI participants available baseline data symptoms (Geriatric Depression Scale; GDS), (AV1451 PET BRAAK I/II SUVR [entorhinal hippocampus]),...
Background: Neuroimaging-based brain-age delta serves as a mediator linking cardiovascular risk factors with cognitive function. In this mediating role, the impact of most prevalent cause decline in elderly, Alzheimer's disease (AD) pathology, has not been previously determined asymptomatic middle-/late-aged individuals. Methods: We included 302 cognitively unimpaired participants ALFA+ cohort, available structural magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) β-amyloid...
Abstract Background Clinical studies indicate that Alzheimer's disease (AD) disproportionately affects women. Although previous reported sex differences in fluid biomarkers, there is a need for comprehensive analysis across the continuum . The aim of this study was to compare AD‐related biomarkers cerebrospinal (CSF) and plasma between women men middle‐aged cognitively‐unimpaired individuals at risk AD. Method We measured Aβ42, Aβ40, Mid (M)‐p‐tau 181, N‐terminal (N)‐p‐tau N‐p‐tau 217,...
Abstract Background Subjective cognitive decline (SCD) is often related to affective symptoms and both predict decline. We investigated whether SCD status predicted higher anxiety/depression during the Covid19‐related confinement, along with amyloid positivity in cognitively unimpaired older adults. Method included 205 participants from ALFA+ study (Table 1). During anxiety depression (Hospital Depression Anxiety scale, HADS), perceived stress (Perceived Stress Scale) resilience (Brief...
Abstract Background Stress is associated with adverse health outcomes, but the pathways through which stressful life events affect brain health, and age periods most vulnerable to these effects, are unknown. We investigated questions in relation Alzheimer’s disease (AD) pathophysiology integrity cognitively unimpaired participants at risk for AD. Method In this cross‐sectional cohort study, 1168 completed 18‐item Elder’s Life Inventory measuring occurrence (and occurrence) of events. Of...
Abstract Background Medial temporal lobe structures are particularly vulnerable in age‐related neurodegenerative diseases. Here, we investigated the brain reorganization that allows maintaining relatively normal global cognitive functioning patients with herpes simplex encephalitis (HSE) – an infectious neurological disease ‐ marked focal atrophy most pronounced medial lobes, hippocampus. Using rs‐fMRI (i) characterized patterns of functional network organization, and (ii) compared...
Abstract Background Cognitively unimpaired (CU) adults with Alzheimer’s disease (AD) pathologic change may be more vulnerable to developing neuropsychiatric symptoms. We reported an association of higher β‐amyloid (Aβ) and increased anxiety/depression during the COVID‐19 lockdown in CU (Akinci et al., 2022). Here, we investigated whether changes Aβ 1−42 predict post‐traumatic stress disorder (PTSD) symptomatology following at risk for AD. Method included 128 participants who underwent lumbar...
Abstract Background COVID‐19‐related SARS‐CoV‐2 infection has been linked with brain abnormalities and cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD), neuroinflammation, neuronal injury. Whether COVID‐19 increases the brain’s vulnerability to development AD is unclear. In participants at an increased risk AD, we investigated association pre‐ post‐pandemic biomarkers. Method We included 132 cognitively unimpaired adults from ALFA+ cohort (52‐71 years, 61.4% women) who...