A5039986534- Functional Brain Connectivity Studies
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Electroconvulsive Therapy Studies
- Attention Deficit Hyperactivity Disorder
- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Mental Health Research Topics
- Treatment of Major Depression
- Congenital heart defects research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural dynamics and brain function
- Neurogenesis and neuroplasticity mechanisms
- Genetic Associations and Epidemiology
- Genomic variations and chromosomal abnormalities
- Traumatic Brain Injury and Neurovascular Disturbances
- Bioinformatics and Genomic Networks
- Bipolar Disorder and Treatment
- Neural and Behavioral Psychology Studies
- Mental Health and Psychiatry
- S100 Proteins and Annexins
- Memory and Neural Mechanisms
- Neuroscience and Music Perception
University of Iowa
2018-2025
Otto-von-Guericke University Magdeburg
2024-2025
University Hospital Magdeburg
2024
Center for Behavioral Brain Sciences
2024
University of Iowa Health Care
2023
University of Iowa Hospitals and Clinics
2023
Carver Bible College
2021
RWTH Aachen University
2011-2020
Jülich Aachen Research Alliance
2011-2020
Universitätsklinikum Aachen
2005-2019
Lactate dehydrogenase type A (LDH-A) is a key metabolic enzyme catalyzing pyruvate into lactate and excessively expressed by tumor cells. Transforming growth factor-β2 (TGF-β2) regulator of invasion in high-grade gliomas, partially inducing mesenchymal phenotype remodeling the extracellular matrix. In this study, we tested hypothesis that metabolism regulates TGF-β2–mediated migration glioma Small interfering RNA directed against LDH-A (siLDH-A) suppresses, induces, TGF-β2 expression,...
Results on grey matter (GM) structural alterations in autism spectrum disorder (ASD) are inconclusive. Moreover, little is known about age effects brain-structure abnormalities ASD beyond childhood. Here, we aimed to examine regional GM volumes a large sample of children, adolescents, and adults with ASD. Magnetic resonance imaging scans were obtained 47 male subjects 51 matched healthy controls aged 8-50 years. We used whole-brain voxel-based morphometry first assess group differences...
BackgroundDisentangling psychopathological heterogeneity in schizophrenia is challenging, and previous results remain inconclusive. We employed advanced machine learning to identify a stable generalizable factorization of the Positive Negative Syndrome Scale used it subtypes as well their neurobiological differentiations.MethodsPositive data from Pharmacotherapy Monitoring Outcome Survey cohort (1545 patients; 586 followed up after 1.35 ± 0.70 years) were for factor structure by an...
Genes associated with risk for brain disease exhibit characteristic expression patterns that reflect both anatomical and cell type relationships. Brain-wide transcriptomic of genes provide a molecular-based signature, based on differential co-expression, is often unique to disease. Brain diseases can be compared aggregated the similarity their signatures which associates from diverse phenotypic classes. Analysis 40 common human identifies 5 major transcriptional patterns, representing...
Abstract Sleep deprivation has far-reaching consequences on the brain and behavior, impacting memory, attention, metabolism. Previous research focused gene expression changes in individual regions, such as hippocampus or cortex. Therefore, it is unclear how uniformly heterogeneously sleep loss affects brain. Here, we use spatial transcriptomics to define impact of a brief period across male mice. We find that induced pronounced differences brain, with greatest hippocampus, neocortex,...
Versican is a large chondroitin sulphate proteoglycan produced by several tumour cell types, including high-grade glioma. The increased expression of certain versican isoforms in the extracellular matrix (ECM) plays role growth, adhesion and migration. Transforming growth factor-beta2 (TGF-beta2) an important modulator glioma invasion, partially remodeling ECM. However, it unknown whether interacts with during malignant progression cells. Here, we analysed effect TGF-beta2 on isoforms. V0/V1...
Neurodevelopmental disorders, including autism spectrum are highly male biased, but the underpinnings of this unknown. Striatal dysfunction has been strongly implicated in pathophysiology neurodevelopmental raising question whether there sex differences how striatum is impacted by genetic risk factors linked to disorders. Here we report male-specific deficits striatal function important reward learning a mouse model 16p11.2 hemideletion, mutation that associated with particularly and...
Sleep disturbances and hyperactivity are prevalent in several neurodevelopmental disorders, including autism spectrum disorders (ASDs) attention deficit-hyperactivity disorder (ADHD). Evidence from genome-wide association studies indicates that chromosomal copy number variations (CNVs) associated with increased prevalence of these disorders. In particular, CNVs region 16p11.2 profoundly increase the risk for ASD ADHD, more common males than females. We hypothesized mice hemizygous deletion...
BackgroundDespite the marked interindividual variability in clinical presentation of schizophrenia, extent to which individual dimensions psychopathology relate functional brain networks among patients remains unclear. Here, we address this question using network-based predictive modeling along 4 data-driven symptom dimensions. Follow-up analyses assess molecular underpinnings by relating them neurotransmitter-receptor distribution patterns.MethodsWe investigated resting-state magnetic...
Genomic mechanisms enhancing risk in males may contribute to sex bias autism. The ubiquitin protein ligase E3A gene ( Ube3a ) affects cellular homeostasis via control of turnover and by acting as transcriptional coactivator with steroid hormone receptors. Overdosage duplication or triplication chromosomal region 15q11-13 causes 1 2% autistic cases. Here, we test the hypothesis that increased dosage influence autism-relevant phenotypes a sex-biased manner. We show mice extra copies exhibit...
Objectives. The aim of the study was to document present situation electroconvulsive therapy (ECT) in Germany, compare its handling with regard other industrialized countries and a survey 12 years ago. Methods. A questionnaire on frequency type administration ECT 2008 sent electronically 423 psychiatric hospitals. As needed, up five reminders were carried out by telephone. On this occasion, question whether is administered, could be clarified for each hospital. Results. total 43% (183/423)...
Abstract Neurodevelopmental disorders, such as ASD and ADHD, affect males about three to four times more often than females. 16p11.2 hemideletion is a copy number variation that highly associated with neurodevelopmental disorders. Previous work from our lab has shown mouse model of (del/+) exhibits male-specific behavioral phenotypes. We, therefore, aimed investigate magnetic resonance imaging (MRI), whether del/+ animals also exhibited sex-specific neuroanatomical endophenotype. Using the...
Anorexia nervosa (AN) often begins in adolescence, however, the understanding of underlying pathophysiology at this developmentally important age is scarce, impeding early interventions. We used diffusion tensor imaging (DTI) to investigate microstructural white matter (WM) brain changes including an experimental longitudinal follow-up. acquired whole diffusion-weighted scans 22 adolescent female hospitalized patients with AN admission and nine longitudinally discharge after weight...