A5039405876- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Cancer Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Mental Health Research Topics
- Cervical Cancer and HPV Research
- Advanced MRI Techniques and Applications
- Perfectionism, Procrastination, Anxiety Studies
- Neural and Behavioral Psychology Studies
- Respiratory Support and Mechanisms
- Ultrasound in Clinical Applications
- EEG and Brain-Computer Interfaces
- Radiation Dose and Imaging
- Medical Imaging and Pathology Studies
- Venous Thromboembolism Diagnosis and Management
- Neural dynamics and brain function
- Infectious Diseases and Tuberculosis
- Parathyroid Disorders and Treatments
- Endometrial and Cervical Cancer Treatments
- Vascular anomalies and interventions
- Reliability and Maintenance Optimization
- Digital Radiography and Breast Imaging
- Syphilis Diagnosis and Treatment
Stellenbosch University
2015-2024
Tygerberg Hospital
2014-2023
Wellcome Centre for Infectious Diseases Research in Africa
2020
University of Cape Town
2020
Abstract Background There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during persisting metabolic activity after apparent clinical cure. This poses challenge quantifying scan-based markers burden disease activity. We used semi-automated, whole quantification analyse serial scans from Catalysis TB Treatment Response Cohort identify characteristics that best...
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a major contributor to morbidity and mortality in (SLE) patients. To date no single clinical, laboratory or imaging test has proven accurate for NPSLE diagnosis which testament the intricate multifactorial pathophysiological mechanisms suspected exist. Functional with FDG PET-CT shown promise diagnosis, detecting abnormalities prior changes evident on anatomical imaging. Research indicates that may be more aggressive people of African...
A considerable burden of the tuberculosis (TB) epidemic is found in adolescents. The reasons for increased susceptibility to TB infection and higher incidence disease adolescence, compared with 5-10 years old age group, are incompletely understood. Despite pressing clinical public health need better understand address adolescent TB, research this field remains limited.Teen an ongoing prospective observational cohort study that aims biology, morbidity social context TB. plans recruit 50...
Abstract Introduction The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic had a significant impact on tuberculosis (TB) control globally, with the number of new TB diagnoses decreasing. Coinfection some viruses, especially measles, could aggravate in children. This is presumably result depressed cellular immunity. Reports children and SARS‐CoV‐2 coinfection are limited. Methods A retrospective analysis up to 13 years old admitted Tygerberg Hospital, Cape Town, South...
Individualised patient treatment approaches demand precise determination of initial disease extent combined with early, accurate assessment response to treatment, which is made possible by positron emission tomography/computed tomography (PET/CT). PET a non-invasive tool that provides tomographic images and quantitative parameters perfusion, cell viability, proliferation and/or metabolic activity tissues. Fusion the functional information morphological detail provided CT as PET/CT can...
Abstract Many psychiatric disorders are characterized by altered social cognition. The importance of cognition has previously been recognized the National Institute Mental Health Research Domain Criteria project, in which it features as a core domain. Social task‐based functional magnetic resonance imaging (fMRI) currently offers most direct insight into how brain processes information; however, resting‐state fMRI may be just important understanding biology and network nature processing....
Preoperative localization of parathyroid lesions is potentially beneficial in renal patients with hyperparathyroidism. The aim this study was to determine the localizing value hybrid single-photon emission computed tomography combined low-dose x-ray (SPECT/LDCT) compared SPECT alone and whether LDCT improved reader confidence.A retrospective examined scintigraphy results previously referred a diagnosis All underwent planar using technetium-99m (Tc)-pertechnetate, which immediately followed...
Introduction Positron emission tomography-computed tomography (PET-CT) imaging is commonly used to identify nodal involvement in locally advanced cervical carcinoma, but its appropriateness for that purpose among HIV-positive patients has rarely been studied. We analyzed PET-CT findings and subsequent treatment prescribed with carcinoma Cape Town, South Africa. Methods identified a cohort of consecutive International Federation Gynecology Obstetrics (FIGO) stage IIB IIIB at our cancer center...
We present an unusual case of syphilitic pancreatitis and ascending aortitis in a 41-year-old HIV-negative male patient presenting to tertiary institution with obstructive jaundice. After battery investigations that included computed tomography (CT) 18F-labelled fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT) imaging, syphilis serology histology, diagnosis was made. The responded favourably antibiotics, resolution all lesions on FDG PET/CT 13 weeks after initiation...
Introduction Parathyroidectomy is the choice of treatment for patients with primary and tertiary hyperparathyroidism. Scintigraphic, preoperative localization hyperfunctioning parathyroid tissue depends on either a delayed washout technique, subtraction or combination two. The rationale adopting approach its presumed superior sensitivity, but there limited evidence to support this strategy at cost patient inconvenience impact departmental workflows. Objective To determine whether combined...
Right ventricular (RV) outflow obstruction (in the form of valvar or supravalvular pulmonary stenosis) is a well-known complication Takeuchi procedure. We describe 13-year-old male with exertional chest pain, stenosis, RV hypertrophy, and consequent ischemia, which was confirmed using stress echocardiography single-photon emission tomography.
A case of a 50-year-old woman who was referred for the evaluation possible ACTH-dependent Cushing's syndrome (CS) is described. The localisation CS remains difficult despite many advances in diagnostic approaches. No single test can accurately determine location ACTH excess and therefore combination non-invasive imaging, stimulation suppression tests are advised. recent advances, current utility pitfalls each these reviewed. If fail to confidently localise source excess, inferior petrosal...