A5080583098- Congenital Heart Disease Studies
- Congenital heart defects research
- Coronary Artery Anomalies
- High Altitude and Hypoxia
- Travel-related health issues
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Vascular anomalies and interventions
- Nutrition, Genetics, and Disease
- Cardiac Valve Diseases and Treatments
- Child and Adolescent Health
- Renal and Vascular Pathologies
- Adventure Sports and Sensation Seeking
- Tracheal and airway disorders
- Cardiac pacing and defibrillation studies
- Heme Oxygenase-1 and Carbon Monoxide
- Outdoor and Experiential Education
- Immunodeficiency and Autoimmune Disorders
- Cardiac Structural Anomalies and Repair
- Genomic variations and chromosomal abnormalities
- Cardiovascular Conditions and Treatments
- Kawasaki Disease and Coronary Complications
- Venomous Animal Envenomation and Studies
- Phytochemistry and biological activity of medicinal plants
- Healthcare Operations and Scheduling Optimization
Red Cross War Memorial Children's Hospital
2015-2025
University of Cape Town
2013-2023
Stanley Black & Decker (Taiwan)
2022
Cambridge University Press
2009
Tygerberg Children’s Hospital
2009
Congenital heart disease (CHD) is the most common birth defect globally and coarctation of aorta (CoA) one commoner CHD conditions, affecting around 1/1800 live births. CoA considered a critical severity. Unfortunately, prognosis for child born in low lower-middle income country (LLMICs) with far worse than high-income country. Reduced diagnostic interventional capacities specialists these regions lead to delayed diagnosis treatment, which turn more cases presenting at an advanced stage....
Kawasaki disease (KD) is a recognised precipitant of haemophagocytic lymphohistiocytosis (HLH). Although KD has been previously described in the developing world, there are no reported cases preceding HLH. We report case child with persistent rash and unremitting fever consistent diagnosis KD, who was found to have HLH, after intravenous gamma globulin failed produce clinical response. The made using revised diagnostic criteria for HLH from Histiocyte Society (1994). She fulfilled six eight...
Objectives: The PartneRships in cOngeniTal hEart disease (PROTEA) project aims to establish a densely phenotyped and genotyped Congenital Heart Disease (CHD) cohort for southern Africa. This will facilitate research into the epidemiology genetic determinants of CHD region. paper introduces PROTEA project, characterizes its initial cohort, from Western Cape Province South Africa, compares proportion or “cohort-prevalences” CHD-subtypes with international findings. Methods: is prospective...
A substantial proportion of South Africa (SA)’s population lives at high altitude (>1 500 m), and many travel to very altitudes (>3 m) for tourism, business, recreation or religious pilgrimages every year. Despite this, knowledge acute illnesses is poor among SA doctors. At altitude, the decreasing ambient pressure proportionally decreases available oxygen (hypobaric hypoxia). This triggers both immediate respiratory compensation gradual acclimatisation that occurs over days weeks....
No published data are available on the patient, procedural characteristics, and outcomes of congenital heart disease (CHD) cardiac catheterization performed in low- middle-income countries (LMICs). The objective this study was to describe characteristics patient CHD catheterizations LMICs. Cases between January 2019 December 2020 from 15 centers International Quality Improvement Collaborative Congenital Heart Disease Catheterization Registry (IQIC-CHDCR) were included. Procedural Risk...
Background and Objectives The Western Cape public pediatric cardiac service is under-resourced. COVID-19 regulations are likely to have long-term effects on patient care but may provide insight into capacity requirements. As such, we aimed quantify the impact of this service. Methods An uncontrolled retrospective pre-post study all presenting patients over two, one-year periods; pre-COVID-19 period (01/03/2019–29/02/2020) peri-COVID-19 (01/03/2020–28/02/2021). Results Admissions decreased by...
The 22q11.2 deletion syndrome (22qDS) has more than 180 associated phenotypic features, yet genotype-phenotype correlation remains obscure. Since many of the clinical characteristics are serious, treatable (including congenital heart disease), clinicians must maintain a high index suspicion to recognise suite co-occurring features that suggest diagnosis 22qDS. Óskarsdottir's scoring schedule (the 'O score') is generally used need for confirmatory fluorescent in situ hybridisation (FISH)...
Ductal spasm is a rare yet important complication of device occlusions patent ductus arteriosus. Spasm may result in failure the procedure, under-sizing device, or embolisation implanted as resolves after procedure. We describe novel protocol that rapidly and completely reversed eight prematurely born infants who experienced ductal during cardiac catheterisations for arteriosus occlusion. In total, between 25 34 weeks gestation presented transcatheter occlusion 13 87 months age. All patients...
Congenital heart disease (CHD) is a leading non-infectious cause of pediatric morbidity and mortality worldwide. Although the etiology CHD poorly understood, genetic factors including copy number variants (CNVs) contribute to risk in individuals European ancestry. The presence rare CNVs African populations unknown. This study aimed identify pathogenic likely South patients with CHD.
A common misconception is that wilderness adventure travel risky owing to the nature of objective dangers are encountered, such as avalanches, rock falls, flash floods, failure technical equipment and so forth. However, when one critically examines proximal causes accidents, even those caused by 'objective dangers', it apparent many due 'human factors' or non-technical skills. These broadly defined continuous process identifying avoiding activities, interactions decisions may jeopardise safe...
The primary immunodeficiency diseases (PIDs) constitute a diverse and ever-expanding group of inborn errors affecting wide range immune functions. They are not well documented in sub-Saharan Africa.To describe the spectrum PIDs at tertiary paediatric hospital.A retrospective descriptive study diagnosed Red Cross War Memorial Children's Hospital, Cape Town, South Africa (SA), between 1975 2017 was undertaken.We identified 252 children with PIDs, spanning eight nine categories listed...
Tetralogy of Fallot (TOF) is the first described and most common cyanotic congenital heart anomaly that generated successful surgical palliation procedure definitive intracardiac repair. Classical TOF comprises four typical features right ventricular outflow tract obstruction (RVOTO), hypertrophy (RVH), septal defect (VSD) aortic dextroposition. Complex forms condition include associated with absent pulmonary valve atresia (TOF-PA) or without major aortopulmonary collateral arteries...
Paediatric penetrating cardiac injury is extremely rare, precluding published management guidelines, therefore warranting a case-by-case approach with learning points gleaned from each case.A 7-year-old boy presented to rural hospital stab wound the chest by Withaak (Vachellia tortilis) thorn. The patient was haemodynamically stable on presentation, but 2 cm subcutaneous, pulsatile mass present at apex. Echocardiography revealed foreign body apex into heart, evidence for fistula between...
A growing number of people are undertaking expeditions and adventure travel to previously inaccessible areas. The risks posed by increasing accessibility remote regions interest in extreme sports have not been fully obviated modern equipment communications. Therefore, there remains a requirement for medical care during wilderness expeditions, which expectations formal standards continue increase. Expedition medicine should take cognisance the predicted problems, plan contingencies, be...