A5085422478- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Cardiovascular Conditions and Treatments
- Cardiac Arrhythmias and Treatments
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Tracheal and airway disorders
- Pulmonary Hypertension Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Gallbladder and Bile Duct Disorders
- Electrospun Nanofibers in Biomedical Applications
- Central Venous Catheters and Hemodialysis
- Coronary Artery Anomalies
- Cardiac, Anesthesia and Surgical Outcomes
- Ultrasound in Clinical Applications
- Neuroendocrine Tumor Research Advances
- Minimally Invasive Surgical Techniques
- Cardiac pacing and defibrillation studies
- Diversity and Career in Medicine
- COVID-19 and healthcare impacts
- Radiation Dose and Imaging
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
Joe DiMaggio Children's Hospital
2023-2025
Nationwide Children's Hospital
2016-2025
Memorial Health System
2025
The Ohio State University
2017-2022
Pulmonary Associates
2017
University of Michigan–Ann Arbor
2015
C. S. Mott Children's Hospital
2015
Lurie Children's Hospital
2012
Northwestern University
2012
University of South Florida
2005-2010
We developed a tissue-engineered vascular graft (TEVG) for use in children and present results of U.S. Food Drug Administration (FDA)-approved clinical trial evaluating this patients with single-ventricle cardiac anomalies. The TEVG was used as Fontan conduit to connect the inferior vena cava pulmonary artery, but high incidence narrowing manifested within first 6 months, which treated successfully angioplasty. To elucidate mechanisms underlying early stenosis, we data-informed,...
The Harmony transcatheter pulmonary valve (TPV) is the first U.S. Food and Drug Administration–approved device for severe regurgitation (PR) in native or surgically repaired right ventricular outflow tract (RVOT). One-year safety effectiveness of TPV were evaluated patients from Native Outflow Tract Early Feasibility Study, Pivotal Continued Access representing largest cohort to date recipients. Eligible had PR by echocardiography fraction ≥ 30% cardiac magnetic resonance imaging clinical...
Abstract Background Tissue-engineered vascular grafts (TEVGs) have the potential to advance surgical management of infants and children requiring congenital heart surgery by creating functional conduits with growth capacity. Methods Herein, we used an integrative computational-experimental approach elucidate natural history neovessel formation in a large animal preclinical model; combining vitro accelerated degradation study mechanical testing, implantation studies vivo imaging histology,...
BACKGROUND: Neonates with hypoplastic left heart syndrome variants an intact or highly restrictive atrial septum (HLH-IAS) require immediate postnatal intervention to survive. Emergent decompression (LAD) via a percutaneous hybrid approach is standard, but the comparative effectiveness and outcomes of these approaches remain underexplored. METHODS: A multicenter retrospective analysis all neonates HLH-IAS who underwent LAD in first 36 hours life from January 2009 March 2020 at 14 North...
In a phase 1/2, open-label dose escalation trial, we delivered rAAVrh74.MCK.GALGT2 (also B4GALNT2) bilaterally to the legs of two boys with Duchenne muscular dystrophy using intravascular limb infusion. Subject 1 (age 8.9 years at dosing) received 2.5 × 1013 vector genome (vg)/kg per leg (5 vg/kg total) and subject 2 6.9 5 (1 1014 total). No serious adverse events were observed. Muscle biopsy evaluated 3 or 4 months post treatment versus baseline showed evidence GALGT2 gene expression...
Objectives: We aimed to evaluate the utility of computed tomography angiography (CTA) for coronary compression (CC) prediction in patients with congenital heart disease undergoing balloon-expandable transcatheter pulmonary valve replacement (TPVR). Background: Coronary is a serious complication TPVR, but value preprocedural CTAs assess CC risk largely unexplored. Methods: In all, 586 underwent TPVR between January 2009 and July 2018. Adults pre-TPVR CTA children performed less than one year...
Background: Stent implantation (SI) is more effective than balloon angioplasty for the treatment of coarctation aorta (CoA). Due to technical factors, commonly performed in small patients. We sought evaluate outcomes percutaneous adult sized SI CoA Methods: A single-center retrospective review all patients ≤20 kg who underwent native or recurrent from 2004 2015 was performed. Results: Thirty-nine (20 ≤10 kg) were identified, with 28 (71.8%) having and 22 (56.4%) previously failed...
Improvements in technology offer the ability to refine operations without compromising safety. In this study, we determine whether a modified method of laparoscopic cholecystectomy using three ports and an aggregate incision length 20 mm offers any advantage or poses increased risk. Using 5-mm, 30 degree laparoscope, clip applier, dissector, gall bladder is removed through extended umbilical incision. Standard safety principles were followed: achieving "critical view," lateral retraction...
Abstract Background The purpose of this study was to determine risk factors for development malignant ascites and its prognostic significance in patients with pancreatic cancer. Methods A prospective database queried identify cancer who develop ascites. Stage at presentation, size, location primary tumor, treatment received length survival after onset were determined. Results total 15 identified. Of which 4 (1 stage II, 3 III) underwent pancreaticoduodenectomy manifested 2, 3, 24 47 months...
Abstract Objective We describe the technical considerations of transcatheter implantation CardioMEMS™ HF System (Abbott, Abbott Park, IL) in adult patients with complex palliated congenital heart disease (CHD) and advanced failure (HF). Background Ambulatory pulmonary artery (PA) pressure monitoring implantable hemodynamic monitors (IHMs) has been shown to reduce HF‐related hospital admissions non‐CHD populations. is a common late cardiovascular complication CHD necessitating better...
Older patients with achalasia presumably have had a longer, more indolent course than younger patients. This study was undertaken to determine the impact of patient age and duration symptoms on symptom severity outcome after Heller myotomy. Two hundred sixty-two (142 men 120 women), average 49 years +/- 17.7 (SD), undergone laparoscopic Patients scored their using Likert scale subjectively rated overall outcome. Data are presented as median, mean SD, when appropriate. Follow-up is 25 months,...