A5080656850- Electrospun Nanofibers in Biomedical Applications
- Infectious Aortic and Vascular Conditions
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Tissue Engineering and Regenerative Medicine
- Appendicitis Diagnosis and Management
- Abdominal Trauma and Injuries
- Cardiac Structural Anomalies and Repair
- Trauma and Emergency Care Studies
- Vascular Procedures and Complications
- Intestinal Malrotation and Obstruction Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Congenital Anomalies and Fetal Surgery
- Anesthesia and Pain Management
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Dermatological and COVID-19 studies
- Neonatal and Maternal Infections
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Surgical Treatments
- Burn Injury Management and Outcomes
- Pelvic floor disorders treatments
- Pressure Ulcer Prevention and Management
- Gastrointestinal Tumor Research and Treatment
West Virginia University Hospitals
2024
Nationwide Children's Hospital
2017-2022
The Ohio State University Wexner Medical Center
2017-2020
The Ohio State University
2018-2019
Centre Hospitalier Universitaire Sainte-Justine
2017
Randall Children's Hospital at Legacy Emanuel
2017
Children's Hospital of Los Angeles
2017
Children's Hospital of Pittsburgh
2017
Boston Children's Hospital
2017
Children's Mercy Hospital
2017
We developed a tissue-engineered vascular graft (TEVG) for use in children and present results of U.S. Food Drug Administration (FDA)-approved clinical trial evaluating this patients with single-ventricle cardiac anomalies. The TEVG was used as Fontan conduit to connect the inferior vena cava pulmonary artery, but high incidence narrowing manifested within first 6 months, which treated successfully angioplasty. To elucidate mechanisms underlying early stenosis, we data-informed,...
Abstract Background Tissue-engineered vascular grafts (TEVGs) have the potential to advance surgical management of infants and children requiring congenital heart surgery by creating functional conduits with growth capacity. Methods Herein, we used an integrative computational-experimental approach elucidate natural history neovessel formation in a large animal preclinical model; combining vitro accelerated degradation study mechanical testing, implantation studies vivo imaging histology,...
Heart valve disease carries a substantial risk of morbidity and mortality. Outcomes are significantly improved by replacement, but currently available mechanical biological replacement valves associated with complications their own. Mechanical have high rate thromboembolism require lifelong anticoagulation. Biological prosthetic much shorter lifespan, they prone to tearing degradation. Both types lack the capacity for growth, making them particularly problematic in pediatric patients. Tissue...
Endovascular approaches (thoracic endovascular aortic repair) have revolutionized treatment of thoracic disease.We report our 20-year experience with this therapy.Four hundred twenty patients (mean age = 69.0 years; 54% male) underwent repair (1993-2013), predominantly for fusiform aneurysm (n 144), saccular 94), acute 64) or chronic 36) dissection, traumatic injury 39). Rupture was present in 80 (19.1%). Most (78.3%) were at high risk open repair. Mean diameter 5.5 cm. Extent included arch...
Guidelines for nonoperative management (NOM) of high-grade pancreatic injuries in children have not been established, and wide practice variability exists. The purpose this study was to evaluate common clinical strategies across multiple pediatric trauma centers develop a consensus-based standard pathway.A multicenter, retrospective review conducted with (American Association Surgeons Trauma grade III-V) treated NOM between 2010 2015. Data were collected on demographics, management,...
Alvimopan was approved by the Food and Drug Administration in May 2008 has been shown to accelerate gastrointestinal recovery after colectomy. Our independent study evaluated alvimopan as it is used actual hospital practice state of Michigan. We hypothesized that significantly decreases incidence prolonged ileus reduces length stay (LOS) patients who have undergone colectomy.We identified 4749 from Michigan Surgical Quality Collaborative (N = 28 hospitals) database between August 2007...
This multidisciplinary work shows the feasibility of replacing fetal pulmonary valve with a percutaneous, transcatheter, fully biodegradable tissue-engineered heart (TEHV), which was studied in vitro through accelerated degradation, mechanical, and hemodynamic testing vivo by implantation into lamb. The TEHV exhibited only trivial stenosis regurgitation no echocardiogram. Following implantation, fetus matured delivered at term. Replacing stenotic functional has potential to interrupt...
Most tissue-engineered arterial grafts are complicated by aneurysmal dilation secondary to insufficient neotissue formation after scaffold degradation. The optimal graft would form an organized multilayered structure with a robust extracellular matrix that could withstand pressure. purpose of the current study was determine how oversizing biodegradable affects long-term formation. Size-matched (1.0 mm, n = 11) and oversized (1.6 9) electrospun polycaprolactone/chitosan scaffolds were...
Bioresorbable vascular grafts (BVGs) can transform biologically into active blood vessels and represent an alternative to traditional synthetic conduits, which are prone complications such as infection thrombosis. Although platelet-derived growth factors c-Kit positive cells play important role in smooth muscle cell (SMC) migration proliferation injury, atherosclerosis, or allograft, their roles the remodeling process of arterial BVG remains unknown. Thus, we assessed neottisue formation on...
This is a case of female toddler presenting with minor injury to the right lower extremity progressively worsening erythema and oedema. Initial workup revealed elevated inflammatory markers imaging significant soft tissue gas. The overall clinical presentation was highly suggestive necrotising infection. patient expeditiously managed fluid resuscitation, intravenous antibiotics admission intensive care. required multiple operative interventions for excisional debridement grossly necrotic...
Despite being one of the most common pediatric surgical diseases, some cases appendicitis are far from straightforward to diagnose. We present here an interesting case chronic, retrocecal in a dancer who presented with isolated back pain.
12 Patienten mit mykotischen Aneurysmen (7 im aorto-iliacalen Bereich, 5 peripheren bzw. viszeralen Aneurysmen) wurden in einem Zeitraum von 6 Jahren behandelt und retrospektiv analysiert. Es handelte sich um 10 männliche 2 weibliche Durchschnittsalter 53 Jahren. hatten multiple Aneurysmen. Ein Erregernachweis konnte 2/3 der Fälle geführt werden, wobei über 80 % Staphylokokken Salmonellen nachweisbar waren. Beim Befall peripherer Arterien ist häufig ein pulsatiler Tumor tastbar, welcher...