A5075599496- Anesthesia and Sedative Agents
- Sepsis Diagnosis and Treatment
- Thermal Regulation in Medicine
- Immune Response and Inflammation
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Heart Rate Variability and Autonomic Control
- Respiratory Support and Mechanisms
- Dermatological and COVID-19 studies
- Animal and Plant Science Education
- Adipose Tissue and Metabolism
- Biomedical and Chemical Research
- Anesthesia and Neurotoxicity Research
- Streptococcal Infections and Treatments
- Metabolism and Genetic Disorders
- Animal testing and alternatives
- Blood Coagulation and Thrombosis Mechanisms
- Diet, Metabolism, and Disease
- Palliative and Oncologic Care
- Cardiovascular Disease and Adiposity
- Mitochondrial Function and Pathology
- Family and Patient Care in Intensive Care Units
- Heart rate and cardiovascular health
- Cardiac Arrest and Resuscitation
- Neonatal and Maternal Infections
Universidade do Estado do Rio de Janeiro
2005-2024
West Virginia University Hospitals
2024
Committee on Publication Ethics
2014
Universidade Federal de Roraima
2014
Hospital Universitário Pedro Ernesto
2013
Universidade de São Paulo
2007
Dexmedetomidine, an α-2 adrenergic receptor agonist, has already been used in septic patients although few studies have examined its effects on microcirculatory dysfunction, which may play important role perpetuating sepsis syndrome. Therefore, the authors designed a controlled experimental study to characterize of dexmedetomidine endotoxemia rodent model that allows vivo microcirculation.After skinfold chamber implantation, 49 golden Syrian hamsters were randomly allocated five groups: (1)...
Background and ObjectiveApart from its inotropic property, milrinone has vasodilator, anti-inflammatory antithrombotic effects that could assist in the reversal of septic microcirculatory changes. This paper investigates on endotoxemia-related changes compares them to those observed with use norepinephrine. Materials MethodsAfter skinfold chamber implantation procedures endotoxemia induction by intravenous Escherichia coli lipopolysaccharide administration (2 mg.kg-1), male golden Syrian...
Experimental data suggest that ivabradine, an inhibitor of the pacemaker current in sinoatrial node, exerts beneficial effects on endothelial cell function, but it is unclear if this drug could prevent microcirculatory dysfunction septic subjects, improving tissue perfusion and reducing organ failure. Therefore, study was designed to characterize ivabradine a murine model abdominal sepsis using intravital videomicroscopy.Twenty-eight golden Syrian hamsters were allocated four groups:...
Obesity is associated with the impairment of endothelial function leading to initiation atherosclerotic process. As obesity a multiple grade disease, we have hypothesized that an increasing and vascular smooth muscle cell functions occurs from lean subjects severe obese ones, creating window opportunities for preventive measures. Thus, present study was carried out investigate in which dysfunction can be detected if there as body mass index increases. According index, were allocated into...
Relative hypovolemia is frequently found in early stages of severe sepsis and septic shock prompt aggressive fluid therapy has become standard care improving tissue perfusion patient outcome. This paper investigates the role nitric oxide pathway on beneficial microcirculatory effects resuscitation.After skinfold chamber implantation procedures endotoxemia induction by intravenous Escherichia coli lipopolysaccharide administration (2 mg x kg(-1)), male golden Syrian hamsters were resuscitated...
A comunidade científica brasileira clama por uma sistematização definitiva e norma federal abrangente realista, mais orientadora reguladora, menos sancionadora, onde a questão da pesquisa com animais possa ser bem contemplada. OBJETIVO: Descrever situação em que se encontra regulamentação para o uso de treinamento científica, no Brasil. MÉTODOS: Foi identificada discutida legislação existente Brasil Estado do Rio Janeiro acerca utilização na científica. RESULTADOS: Não existe geral...
Pacientes críticos invariavelmente estão ansiosos, agitados, confusos, desconfortáveis e/ou com dor.Neste contexto, analgésicos e sedativos são amplamente utilizados nas unidades de terapia intensiva (UTIs).Algumas vezes, em casos mais específicos, o bloqueio neuromuscular também é utilizado.A administração agentes sedativos, bloqueadores neuromusculares na UTI tem aspectos próprios e, muitos casos, seu uso se diferencia daquele encontrado no ambiente cirúrgico.Na UTI, decorrência do pior...
OBJECTIVE: Apart from its anticoagulant properties, heparin has vasodilator and anti-inflammatory effects that could assist in the reversal of septic microcirculatory changes.This paper investigates on endotoxemia-related changes compares them to those observed with use recombinant human activated protein C. METHODS: After skinfold chamber implantation procedures endotoxemia induction by intravenous Escherichia coli lipopolysaccharide administration (2 mg.kg 21 ), male golden Syrian hamsters...
*Laboratory for Clinical and Experimental Research in Vascular Biology–BioVasc, Department of Physiological Sciences, Biomedical Center, Rio de Janeiro State University; †Internal Medicine Department, Andaraí Federal Hospital, Janeiro, Brazil.
RESUMO Introdução: Embora na literatura médica existam diversas métricas para avaliar a qualidade dos programas de residência, os instrumentos avaliativos tendem focar as dimensões residentes e preceptores. Isso negligencia uma ampla gama partes interessadas (stakeholders), cujas perspectivas são fundamentais compreensão holística da programas. Objetivo: Diante desse contexto, esta revisão teve como objetivos mapear principais stakeholders envolvidos residência médica, identificar...
This is a case of female toddler presenting with minor injury to the right lower extremity progressively worsening erythema and oedema. Initial workup revealed elevated inflammatory markers imaging significant soft tissue gas. The overall clinical presentation was highly suggestive necrotising infection. patient expeditiously managed fluid resuscitation, intravenous antibiotics admission intensive care. required multiple operative interventions for excisional debridement grossly necrotic...
The Myasthenia gravis (MG) is an autoimmune disease that affects neuromuscular transmission and leads to a large variation of sensibility on depolarizing nondepolarizing blocking drugs. Sugammadex new drug with the capability successfully revert blocking. This case report will show patient MG was scheduled for thymectomy, objective use sugammadex reverse rocuronium induced deep level block observing safe without complications.
ObjectivesTo characterize an experimental model of pulmonary embolism by studying hemodynamics, lung mechanics and histopathologic derangements caused microembolism in pigs.To identify alterations after that may be similar to those evidenced inflammatory conditions.Materials methods Ten Large White pigs (weight 35-42 kg) were instrumented with arterial catheters, was induced five injection polystyrene microspheres (diameter ~300 µM), order obtain a mean pressure twice the baseline value.Five...
In rare cases, rocuronium has been associated with dose-related tachycardia, probably by a cardiac muscarinic M2 receptor blockade mechanism. We report the case of 30-year-old female who underwent excision branchial cyst under general anesthesia. This patient presented an episode sinus tachycardia (130 bpm) shortly after anesthesia induction propofol, sufentanyl, and rocuronium. Tachycardia could not be explained any cause other than use rocuronium, which was reverted sugammadex. Two minutes...
Malignant hyperthermia (MH) is a rare and autosomal dominant myopathy triggered by volatile anesthetics depolarizing neuromuscular blocking agents such as succinylcholine characterized an acute hypermetabolic clinical state. This report presents the importance of preoperative preparation perioperative management patients with family history MH, in which there no possibility diagnostic confirmation. Attention must be directed to anesthetic machine because modern workstations need longer...
Due to its high incidence, morbidity, mortality and cost the healthcare system, sepsis stands out among many indications for intensive care unit admission. The microcirculatory dysfunction plays a central role in genesis maintenance of septic syndrome, being pathophysiologic milestone this syndrome. In fact, one can say that is disorder microcirculation first organ fail during progression multiple syndrome death. It now known that, despite adequate treatment macro-hemodynamics, there little...