A5026374836- Thermoregulation and physiological responses
- Diagnosis and Treatment of Venous Diseases
- Cardiovascular Health and Disease Prevention
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Heart Rate Variability and Autonomic Control
- Venous Thromboembolism Diagnosis and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Sepsis Diagnosis and Treatment
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nitric Oxide and Endothelin Effects
- Blood properties and coagulation
- Obesity, Physical Activity, Diet
- Exercise and Physiological Responses
- Peripheral Artery Disease Management
- Body Contouring and Surgery
- Diet, Metabolism, and Disease
- Thermal Regulation in Medicine
- Menopause: Health Impacts and Treatments
- Eicosanoids and Hypertension Pharmacology
- Dermatologic Treatments and Research
- Traumatic Brain Injury and Neurovascular Disturbances
Universidade do Estado do Rio de Janeiro
2016-2025
Hospital Universitário Pedro Ernesto
2022-2024
Weatherford College
2020
Universidade do Porto
2017
Committee on Publication Ethics
2014
Hôpital Rangueil
2010
Centre Hospitalier Universitaire de Poitiers
2010
Universidade Federal do Estado do Rio de Janeiro
2008
Universidade Estadual de Campinas (UNICAMP)
2006
Hospital de Clínicas da Unicamp
2006
Coronary artery disease (CAD) is the leading cause of death worldwide. Patients with CAD exhibit increased levels kynurenine (KYN) pathway (KP) metabolites, which are key products tryptophan (TRP) catabolism and have been identified as predictive markers for cardiovascular events atherosclerosis progression. However, effects exercise on KP metabolites their influence inflammation in these patients remain poorly understood. We aim to investigate exercise’s acute chronic carotid intima-media...
Metabolic syndrome is an important risk factor for cardiovascular disease. Adipokines interfere with insulin action and endothelial cell function. We investigated the relationship among adipokines, metabolic factors, inflammatory markers, vascular reactivity in obese subjects lean controls.Cross-sectional study of 19 8 volunteers evaluated as controls. Vascular was assessed by venous occlusion pletysmography measuring braquial forearm blood flow (FBF) resistance (VR) responses to...
Abstract Background Obesity is a chronic disease associated to an inflammatory process resulting in oxidative stress that leads morpho-functional microvascular damage could be improved by some dietary interventions. In this study, the intake of Brazil nuts ( Bertholletia excelsa ), composed bioactive substances like selenium, α- e γ- tocopherol, folate and polyunsaturated fatty acids, have been investigated on antioxidant capacity, lipid metabolic profiles nutritive skin microcirculation...
The effects of a recreational soccer program (RSP) upon body composition, heart rate variability (HRV), biochemical markers, cardio-respiratory fitness, and endothelial function in obese adolescents were investigated. A randomised controlled clinical trial was conducted with 30 aged 12–17 years mass index (BMI) >2 standard deviations WHO reference values, which assigned to RSP (n = 10, 2 girls) control 4 groups. 12-week included 60-min sessions performed 3 times/week. BMI, waist...
Dexmedetomidine, an α-2 adrenergic receptor agonist, has already been used in septic patients although few studies have examined its effects on microcirculatory dysfunction, which may play important role perpetuating sepsis syndrome. Therefore, the authors designed a controlled experimental study to characterize of dexmedetomidine endotoxemia rodent model that allows vivo microcirculation.After skinfold chamber implantation, 49 golden Syrian hamsters were randomly allocated five groups: (1)...
OBJECTIVE—Endothelial dysfunction is an early marker of atherosclerosis seen in type 2 diabetic subjects. Metformin commonly used the treatment diabetes and has known vasculoprotective effects beyond its hypoglycemic ones. We aimed to investigate vascular metformin first-degree relatives with metabolic syndrome patients. RESEARCH DESIGN AND METHODS—The study included 31 subjects (age 38.3 ± 7.6 years BMI 36.3 5.2 kg/m2), who were patients had normal glucose tolerance. The randomly assigned...
Abstract We have previously reported that exogenous bradykinin activates immature dendritic cells (DCs) via the B2 receptor (B2R), thereby stimulating adaptive immunity. In this study, we show these premises are met in a model of s.c. infection by Trypanosoma cruzi, protozoan liberates kinins from kininogens through its major protease, cruzipain. Intensity B2R-dependent paw edema evoked trypomastigotes correlated with levels IL-12 produced CD11c+ isolated draining lymph nodes. The response...
Chronic venous disease (CVD) is a pathology with unfavorable outcome when treated and/or followed up incorrectly. In addition to macroscopic changes, CVD also causes changes in microcirculation. Based on these hypotheses, non-invasive test quantify the evolution of microangiopathy may be useful assess effects and benefits treatment. Fifty female patients varicose veins classified by clinical class C2 or C3 CEAP classification were selected allocated randomly two groups: foam sclerotherapy...
Chrononutrition may affect childhood cardiometabolic health. Understanding this relationship be crucial for managing paediatric obesity. To investigate the between chrononutrition and risk factors in prepubertal children. This cross-sectional study included 93 participants (50 males, 5-12 years), categorized as healthy weight (HW, n = 34), overweight (OV, 10), obese (OB, 23) severe obesity (SOB, 26). 24-h dietary recalls assessed participants' caloric energy substrate intake, analysed...
The spontaneous rhythmic motor activity (vasomotion) of arterioles was studied in vivo the hamster cheek pouch by means intravital microscopy. In control conditions, arteriolar vasomotion regularly present healthy preparations, independent anesthesia (pentobarbital sodium or alpha-chloralose), composition superfusate [tris(hydroxymethyl)aminomethane-buffered N-2-hydroxy-ethylpiperazine-N'-2-ethanesulfonic acid-supported HCO3(-)-buffered saline solutions) a combined nerve, alpha- and beta-...
The effects of resistance training (RT) alone upon endothelial function, metabolic and hemodynamic profiles, physical fitness, body composition, inflammatory biomarkers in nondiabetic obese adolescents were investigated.Adolescents assigned into nonobese control (CG, n = 20; 14.7 ± 1.4 yr) (OB, 24; 14.1 1.0 groups. Muscle skin reactivity, at-office 24-h ambulatory blood pressure, profile, adipocytokines, aerobic strength fitness assessed before after 12 wk RT only at admission).After RT,...
Stimulation of cerebrovascular parasympathetic nerves markedly increases cortical blood flow. Nitric oxide (NO) or a NO-containing compound is present in these and may therefore, upon release, be partly responsible for the flow increase. In addition, transmitters released from cause synthesis release this endothelium. The contribution NO to (CoBF) increase during stimulation was elucidated rat by laser–Doppler flowmetry. Thirty-minute exposure circulating N ω -nitro-l-arginine methyl ester...
In the present study, changes in frequency and amplitude of rhythmic variations (vasomotion) blood flow intact cerebral circulation rat were investigated using laser‐Doppler flowmetry (LDF) during stepwise decrease mean arterial pressure (MABP) hyper‐and hypocapnia. Experiments performed on 12 adult Sprague‐Dawley rats either sex, anaesthetized with α‐chloralose. The rat's head was fixed a stereotaxic frame small hole made parietal bone but dura thin inner layer kept intact. microvascular...