Metabolic syndrome is an important risk factor for cardiovascular disease. Adipokines interfere with insulin action and endothelial cell function. We investigated the relationship among adipokines, metabolic factors, inflammatory markers, vascular reactivity in obese subjects lean controls.Cross-sectional study of 19 8 volunteers evaluated as controls. Vascular was assessed by venous occlusion pletysmography measuring braquial forearm blood flow (FBF) resistance (VR) responses to...

OBJECTIVE—Endothelial dysfunction is an early marker of atherosclerosis seen in type 2 diabetic subjects. Metformin commonly used the treatment diabetes and has known vasculoprotective effects beyond its hypoglycemic ones. We aimed to investigate vascular metformin first-degree relatives with metabolic syndrome patients. RESEARCH DESIGN AND METHODS—The study included 31 subjects (age 38.3 ± 7.6 years BMI 36.3 5.2 kg/m2), who were patients had normal glucose tolerance. The randomly assigned...

Gynoid lipodystrophy, also known as cellulite, is a common multifactorial entity that affects millions of women around the world. There have been few scientific articles dealing with its physiology and treatment in past years, vascular changes seem to play an important role pathophysiology. Skin microvascular alterations can be observed noninvasively new method called orthogonal polarization spectral imaging, which was used evaluate effectiveness anticellulite drug composed mainly 7%...

Normovolemic hemodilution is an effective strategy to limit perioperative homologous blood transfusions. The reduction of hematocrit related results in reduced arterial oxygen content, which initially compensated for by increase cardiac output and extraction ratio. To the efficacy hemodilution, a low should be aimed for; however, this implies risk myocardial ischemia tissue hypoxia.To assess whether can extended lower values use hemoglobin-based artificial carrier solution.Prospective,...

Objectives. To evaluate microcirculatory changes (functional and morphological) in primary antiphospholipid syndrome (PAPS) patients. Methods. Thirty-one patients were examined using nailfold videocapillaroscopy (18 PAPS 13 healthy subjects). The subdivided into two subgroups, with lupus anticoagulant (n = 8) anticardiolipin 10) antibodies. Capillary morphology was determined; diameters (µm) functional capillary density (FCD, number capillaries/mm2) measured control conditions. Blood flow...

To determine if capillary rarefaction persists when hypertension is treated with angiotensin converting enzyme inhibitor, thiazidic diuretic and/or beta-blocker, and to identify which microcirculatory alterations (structural functional) persist after anti-hypertensive treatment. We evaluated 28 well-controlled essential hypertensive patients 19 normotensive subjects. Nailfold videocapillaroscopy examination of the fourth finger left hand was used functional densities at baseline, during...

Abstract Aims Insulin resistance and a parental history of diabetes mellitus are independently associated with endothelial dysfunction. Oxidative stress has pivotal role in the pathophysiology vascular injury. Metformin, addition to its glucose‐lowering properties, vasculoprotective effects. We investigated whether metformin beneficial effects on nutritive skin capillary circulation deceases oxidative group at high risk for Type 2 (T2DM) cardiovascular disease. Methods Thirty normoglycaemic...

There is a functional decline of endothelial- dependent vasodilatation in the aging process. The aims this study were to investigate if various microcirculatory parameters could correlate anthropometrical variables, oxidative stress and inflammatory biomarkers successful compare results young healthy controls. Healthy elderly women (HE, 74.0 ± 8.7 years, n = 11) controls (YC, 23.1 3.6 24) evaluated through nailfold videocapillaroscopy (NVC), venous occlusion plethysmography (VOP)...

BACKGROUND: Changes in muscle mass, strength, vascular function, oxidative stress, and inflammatory biomarkers were compared older adults after resistance training (RT) performed with low-intensity without blood flow restriction (RT-CON); BFR (RT-BFR); high-intensity (RT-HI). METHODS: Thirty-two untrained individuals (72±7 y) a 12-week RT being randomized into three groups: RT-CON –30% of 1 repetition maximum (RM); RT-BFR 1RM mild (50% arterial occlusion pressure); RT-HI –70% RM. RESULTS:...

Obesity is associated with the impairment of endothelial function leading to initiation atherosclerotic process. As obesity a multiple grade disease, we have hypothesized that an increasing and vascular smooth muscle cell functions occurs from lean subjects severe obese ones, creating window opportunities for preventive measures. Thus, present study was carried out investigate in which dysfunction can be detected if there as body mass index increases. According index, were allocated into...

<b><i>Objective:</i></b> The aim of this study was to investigate the effect oral supplementation with L-arginine on serum biochemical profile, blood pressure, microcirculation, and vasoreactivity/endothelial function in young controls, elderly women without type 2 diabetes mellitus (T2DM). <b><i>Methods:</i></b> Healthy (<i>n</i> = 25), healthy (T2DME, <i>n</i> 23, glycated Hb ≥6.4% mean 7.7 years for duration disease),...

Age-related mechanisms of sarcopenia associated with vascular function have been recently suggested. This study compared and tested associations between muscle mass strength, microcirculation, inflammatory biomarkers, oxidative stress in older adults classified as sarcopenic non-sarcopenic.Thirty-three physically inactive individuals (72±7 yrs) were assigned to age-matched (SG) non-sarcopenic (NSG) groups. Between-group comparisons performed for appendicular skeletal (ASM), handgrip...

Perfluorocarbon (PFC) emulsions are intravascular oxygen therapeutics that temporarily enhance tissue oxygenation in dilutional anemia. However, PFC not resuscitation fluids because PFCs only work optimally the presence of high O2 partial pressure (hyperoxia); moreover, they have no oncotic potential, dosing limitations prevent their use to permanently replace large hemorrhage volumes. Our objective was clarify whether hyperoxia a conventional colloid therapy supplemented by is more...

Peripheral arterial disease may lead to lower limb claudication and increased risk of systemic vascular dysfunction. In this article, the authors have investigated peripheral dysfunction evaluating forearm blood flow using venous occlusion plethysmography, lipid profile, C-reactive protein in 60 patients with moderate intermittent treated during 20 weeks placebo (n = 16), cilostazol (200 mg/d; n 17), or pentoxifylline (1200 15) a randomized double-blinded clinical trial, taking into account...