A5108007229- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and Diving-Related Complications
- Coronary Artery Anomalies
- Healthcare Systems and Public Health
- Muscle Physiology and Disorders
- Infective Endocarditis Diagnosis and Management
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Virus-based gene therapy research
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Legal and Policy Issues
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Cardiac Arrhythmias and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Venous Thromboembolism Diagnosis and Management
- Cardiac pacing and defibrillation studies
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Infectious Aortic and Vascular Conditions
- Congenital heart defects research
Nationwide Children's Hospital
2011-2024
The Ohio State University
2011-2024
Seattle Children's Hospital
2016
Pontificia Universidad Católica de Chile
2016
The University of Texas Southwestern Medical Center
2016
Children's Medical Center
2016
Southwestern Medical Center
2016
Texas Children's Hospital
1981-2016
Children's Hospital of Pittsburgh
2016
Children's Hospital of Los Angeles
2016
We developed a tissue-engineered vascular graft (TEVG) for use in children and present results of U.S. Food Drug Administration (FDA)-approved clinical trial evaluating this patients with single-ventricle cardiac anomalies. The TEVG was used as Fontan conduit to connect the inferior vena cava pulmonary artery, but high incidence narrowing manifested within first 6 months, which treated successfully angioplasty. To elucidate mechanisms underlying early stenosis, we data-informed,...
The Harmony transcatheter pulmonary valve (TPV) was designed for treatment of postoperative regurgitation in patients with repaired right ventricular outflow tracts.The Native TPV EFS (Early Feasibility Study) is a prospective, multicenter, nonrandomized feasibility study. Three-year outcomes are reported.Of 20 implanted patients, 17 completed 3-year follow-up (maximum: 4.1 years). There were no deaths and 2 early explants. One patient did not complete the visit. In available...
Objectives We report the Melody valve implanted and/or expanded to 24‐mm diameter. Background The Medtronic has been up 22 mm in pulmonary position for over a decade. Methods A retrospective chart review was performed on 82 patients who underwent implant. Technical implant method, pre‐ and postimplant echocardiographic findings, initial follow‐up were reviewed. Results Between 04/2008 12/2011, 13 valves successfully 11 patients, median age 35 years (range 16–61 years), (bioprosthetic valve,...
In a previous limb-girdle muscular dystrophy type 2D (LGMD2D) clinical trial, robust alpha-sarcoglycan gene expression was confirmed following intramuscular (
In a phase 1/2, open-label dose escalation trial, we delivered rAAVrh74.MCK.GALGT2 (also B4GALNT2) bilaterally to the legs of two boys with Duchenne muscular dystrophy using intravascular limb infusion. Subject 1 (age 8.9 years at dosing) received 2.5 × 1013 vector genome (vg)/kg per leg (5 vg/kg total) and subject 2 6.9 5 (1 1014 total). No serious adverse events were observed. Muscle biopsy evaluated 3 or 4 months post treatment versus baseline showed evidence GALGT2 gene expression...
This study retrospectively analyzed the data within U.S. Multicenter Registry for Rotational Ablation to determine incidence of coronary perforation during rotational ablation, its angiographic predictors and clinical outcomes 2953 consecutive patients, 3717 lesions. Patients were categorized into Group A (without perforation, N = 2931) B (with 22 patients). Perforation occurred in 0.7% procedures, 0.6% lesions treated was more frequent right (12/ 1105, 1.1%) circumflex (9/761, 1.2%)...
Background: Stent implantation (SI) is more effective than balloon angioplasty for the treatment of coarctation aorta (CoA). Due to technical factors, commonly performed in small patients. We sought evaluate outcomes percutaneous adult sized SI CoA Methods: A single-center retrospective review all patients ≤20 kg who underwent native or recurrent from 2004 2015 was performed. Results: Thirty-nine (20 ≤10 kg) were identified, with 28 (71.8%) having and 22 (56.4%) previously failed...
Recombinant adeno-associated virus (rAAV)rh74.MCK.GALGT2 is a muscle-specific gene therapy that being developed to treat forms of muscular dystrophy. Here we report on an isolated limb infusion technique in non-human primate model, where hindlimb blood flow transiently using balloon catheters concentrate vector targeted leg muscles. A bilateral dose 2.5 × 1013 genomes (vg)/kg/limb was sufficient induce GALGT2-induced glycosylation 10%–60% skeletal myofibers all muscles examined. There...
BACKGROUND: Transverse aortic arch obstruction is a challenging lesion for which stent implantation provides potentially important alternate therapy. The objectives were to evaluate the technical, procedural, and medium-to-long-term clinical outcomes of percutaneous transverse obstruction. METHODS: This retrospective, multicenter study implantation. Univariable multivariable analyses performed. RESULTS: Index catheterization included 187 implants in 146 patients. median age 14.3 years...
The Harmony transcatheter pulmonary valve (TPV) is the first FDA-approved device for severe regurgitation (PR) in native or surgically repaired right ventricular outflow tract (RVOT). Our objective was to evaluate midterm outcomes clinical trial participants who have now completed at least 3 years of follow-up. analysis included patients received a commercially available TPV22 TPV25 (Medtronic, Minneapolis, MN) as part Native Outflow Tract Early Feasibility Study (EFS), TPV Pivotal Trial,...
We sought to describe the leaflet morphology variation in Melody Transcatheter Pulmonary Valve (TPV) and evaluate associated outcomes. The TPV is constructed from harvested bovine jugular venous valves which have been rigorously tested. Natural anatomic variations are seen but not evaluated.A classification system was devised after reviewing a subset of photographed implanted TPVs. All images were blindly reviewed by implanters classified. Midterm hemodynamic outcomes complications TPVs...