A5100691840- Wound Healing and Treatments
- Muscle Physiology and Disorders
- Lower Extremity Biomechanics and Pathologies
- Foot and Ankle Surgery
- Electrospun Nanofibers in Biomedical Applications
- Extracellular vesicles in disease
- Diabetic Foot Ulcer Assessment and Management
- MicroRNA in disease regulation
- Surgical Sutures and Adhesives
- Adipose Tissue and Metabolism
- Advanced biosensing and bioanalysis techniques
- Spine and Intervertebral Disc Pathology
- Airway Management and Intubation Techniques
- Tendon Structure and Treatment
- Ferroptosis and cancer prognosis
- Nausea and vomiting management
- Nanoplatforms for cancer theranostics
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Anesthesia and Sedative Agents
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Virus-based gene therapy research
- Cellular Mechanics and Interactions
- Reproductive Biology and Fertility
Wuhu Fourth People Hospital
2023-2025
Shanghai Jiao Tong University
2017-2024
Army Medical University
2014-2024
Xinqiao Hospital
2017-2024
Nanjing University of Chinese Medicine
2023-2024
University of Maryland, Baltimore
2021-2024
Anhui Medical University
2012-2024
Ruijin Hospital
2021-2024
Viva Biotech (China)
2024
XinHua Hospital
2024
Abstract A desirable microenvironment is essential for wound healing, in which an ideal moisture content one of the most important factors. The fundamental function and requirement dressings to keep at optimal moisture. Here, we prepared serial polyurethane (PU) membrane with graded water vapor transmission rates (WVTRs), WVTR dressing healing was identified by both vitro vivo studies. It found that a 2028.3 ± 237.8 g/m 2 ·24 h able maintain proliferation regular epidermal cells fibroblasts...
Human mesenchymal stem/stromal cells (hMSCs) have been shown to support breast cancer cell proliferation and metastasis, partly through their secretome. hMSCs a remarkable ability survive for long periods under stress, secretome is tumor supportive. In this study, we characterized the cargo of extracellular vesicular (EV) fraction (that in size range 40-150nm) serum deprived (SD-MSCs). Next Generation Sequencing assays were used identify small RNA secreted EVs, which indicated presence...
Autism Spectrum Disorder (ASD) is a severe neurodevelopmental disorder. To enhance the understanding of gut microbiota structure in ASD children at different ages as well relationship between and fecal metabolites, we first used 16S rRNA sequencing to evaluate microbial population cohort 143 aged 2–13 years old. We found that α-diversity group showed no significant change with age, while TD increased which indicates compositional development varies ways are not consistent group. Recent...
Molecular profiling of tumor-derived extracellular vesicles (tEVs) holds great promise for non-invasive cancer diagnosis. However, sensitive and accurate identification tEVs is challenged by the heterogeneity EV phenotypes which reflect different cell origins. Here we present a DNA computation device mediated thermophoresis detection tEVs. The strategy leverages aptamer-based logic gate using multiple protein biomarkers on single EVs as input thermophoretic accumulation to amplify output...
Abstract Molecular computing is an emerging paradigm that plays essential role in data storage, bio-computation, and clinical diagnosis with the future trends of more efficient scheme, higher modularity scaled-up circuity stronger tolerance corrupted inputs a complex environment. Towards these goals, we construct spatially localized, DNA integrated circuits-based classifier (DNA IC-CLA) can perform neuromorphic architecture-based computation at molecular level for medical diagnosis. The...
An ideal wound dressing can both promote healing and prevent bacterial infection. Here, we report a potential prepared by incorporating an optimized concentration of silver nanoparticles (AgNPs) into the microfibers natural eggshell membrane (EM) using environmentally friendly mussel-inspired dopamine. Briefly, acid-treated EM was used as porous for polydopamine-reduced AgNPs synthesis. To obtain optimal cytocompatible concentration, cellular attachment MTT assay were performed with...
A new cyclization pattern between arylidene isoxazolones and enamino esters has been demonstrated, efficiently affording various structurally novel cyclopentenyl spiroisoxazolones with high chemoselectivity in a ball mill. Interestingly, the diastereoselectivity...
BACKGROUND There are many shortcomings in traditional prefabricated rehabilitation insoles for symptomatic flatfoot patients. This study investigated the effects of customized 3-dimensional (3D) printed on pressure and comfort plantar foot MATERIAL AND METHODS Eighty patients with bilateral participated this study. At week 0, were randomly assigned into 1 2 groups. In control group, wore standardize shoes insoles; experimental group insoles. The Footscan® system recorded peak pressure,...
Stimuli-responsive gauze coated with a phase-transitioned lysozyme nanofilm (PTLF@gauze) has been developed, which exhibits great potential for clinical applications by reducing secondary trauma and relieving the pain of patients.
BACKGROUND:Traditional ankle-foot orthoses (AFOs) are not effective in treating plantar fasciitis, while customized 3-dimensional (3D) printed many diseases. This study investigated the effects of 3D AFOs on biomechanics and comfort foot fasciitis. MATERIAL AND METHODS:Sixty patients with bilateral fasciitis aged 31–60 years participated this study. At week 0, were randomly assigned into 2 groups: control group consisting those wearing separate shoes prefabricated AFOs; experimental a shoe...
Abstract Ferritin internalized into tumor cells is degraded and releases iron ions via ferritinophagy. Iron participate in Fenton reaction to produce reactive oxygen species for lipid peroxidation ferroptosis. Inhibition of indoleamine‐2,3‐dioxygenase (IDO) decreases tryptophan elimination induce T activation immunosuppression relief. The active targeting nanoparticles containing ferritin a pH‐sensitive molecular‐switch (FPBC@SN) are developed utilize ferritinophagy‐cascade ferroptosis...
Abstract Overexpression of androgen receptor (AR) is the primary cause castration-resistant prostate cancer, although mechanisms upregulating AR transcription in this context are not well understood. Our RNA-seq studies revealed that SMAD3 knockdown decreased levels and target genes, whereas SMAD4 or SMAD2 had little no effect. ChIP-seq analysis showed global binding to chromatin. Mechanistically, we show binds intron 3 gene promote expression. Targeting these sites by CRISPRi reduced...
The CRISPR/Cas9 system is being used for genome editing purposes by many research groups in multiple plant species. Traditional sequencing methods to identify homozygous mutants are time-consuming, laborious and expensive. We have developed a method screen CRISPR/Cas9-induced through Mutation Sites Based Specific Primers Polymerase Chain Reaction (MSBSP-PCR). MSBSP-PCR was successfully homozygous/biallelic Nicotiana tabacum Arabidopsis thaliana, we speculate that it can be the identification...
Abstract P311, a gene that was identified in 1993, has been found to have diverse biological functions processes such as cell proliferation, migration and differentiation. However, its role fibrosis is unknown. We previously observed P311 highly expressed skin hypertrophic scars. In this study, over-expression detected subset of tubular epithelial cells clinical biopsy specimens renal fibrosis; over-expression, concurrent with α-smooth muscle actin (α-SMA) transforming growth factor beta1...
Small extracellular vesicles (sEVs) are heterogeneous membrane-bound that carry numerous bioactive molecules. Studies have reported sEVs carrying PD-L1 on the surface could contribute to immunosuppression; however, precise mechanisms unclear. To fully dissect their mode of action, it requires qualified methods specifically isolate natural PD-L1-positive from sEVs. This study an aptamer-assisted capture-and-release strategy for traceless isolation The aptamer-anchored magnetic microspheres...
Endovascular treatment (EVT) is a well-established approach for acute ischemic stroke. Whether bridging intravenous thrombolysis (IVT) before EVT confers any benefits remains uncertain. The objective of the study was to compare efficacy and safety direct with or without IVT in patients basilar artery occlusion (BAO).