A5051000940- Wound Healing and Treatments
- Burn Injury Management and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Dermatologic Treatments and Research
- Graphene and Nanomaterials Applications
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Silk-based biomaterials and applications
- Injury Epidemiology and Prevention
- Mesenchymal stem cell research
- Surgical Sutures and Adhesives
- Pressure Ulcer Prevention and Management
- Antimicrobial agents and applications
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Advanced Sensor and Energy Harvesting Materials
- Tissue Engineering and Regenerative Medicine
- Advanced Nanomaterials in Catalysis
- 3D Printing in Biomedical Research
- Photodynamic Therapy Research Studies
- Cardiac Arrest and Resuscitation
- Planarian Biology and Electrostimulation
- Skin Protection and Aging
- Laser Applications in Dentistry and Medicine
Army Medical University
2016-2025
Southwest Hospital
2016-2025
Guangdong University of Technology
2025
Hubei Engineering University
2025
Wenzhou Medical University
2023
First Affiliated Hospital of Wenzhou Medical University
2023
Southwest General Health Center
2015-2021
Burn Institute
2012-2021
Chongqing University
2018-2021
University of Manitoba
2018-2019
Oxidative stress is associated with many acute and chronic inflammatory diseases, yet limited treatment currently available clinically. The development of enzyme-mimicking nanomaterials (nanozymes) good reactive oxygen species (ROS) scavenging ability biocompatibility a promising way for the ROS-related inflammation. Herein we report simple efficient one-step ultrasmall Cu
The advent of conductive self‐healing (CSH) hydrogels, a class novel materials mimicking human skin, may change the trajectory industrial process because their potential applications in soft robots, biomimetic prostheses, and health‐monitoring systems. Here, development mechanically electrically hydrogel based on physically chemically cross‐linked networks is reported. autonomous intrinsic attained through dynamic ionic interactions between carboxylic groups poly(acrylic acid) ferric ions. A...
Abstract A desirable microenvironment is essential for wound healing, in which an ideal moisture content one of the most important factors. The fundamental function and requirement dressings to keep at optimal moisture. Here, we prepared serial polyurethane (PU) membrane with graded water vapor transmission rates (WVTRs), WVTR dressing healing was identified by both vitro vivo studies. It found that a 2028.3 ± 237.8 g/m 2 ·24 h able maintain proliferation regular epidermal cells fibroblasts...
Abstract Engineering therapeutic angiogenesis in impaired tissues is critical for chronic wound healing. Materials can be engineered to deliver specific biological cues that enhance angiogenesis. However, currently available materials have limitations use engineering since the complex inflammation environment of wounds requires spatiotemporal control. Immune cells are central component microenvironment and orchestrate immune responses This study presents a novel approach using delivery...
Excessive production of inflammatory chemokines and reactive oxygen species (ROS) can cause a feedback cycle inflammation response that has negative effect on cutaneous wound healing. The use wound-dressing materials simultaneously absorb scavenge ROS constitutes novel 'weeding uprooting' treatment strategy for conditions. In the present study, composite hydrogel comprising an amine-functionalized star-shaped polyethylene glycol (starPEG) heparin chemokine sequestration as well Cu5.4O...
Abstract Existing surgical tissue adhesives on the market cannot meet desired demand for clinical operations due to their limited adhesivity or undesired cytotoxicity. A new bioadhesive is derived from skin secretion of Andrias davidianus (SSAD). This bioinspired SSAD has significantly stronger adhesion than fibrin glue and improved elasticity biocompatibility when compared cyanoacrylate both ex vivo in vivo. Additionally, SSAD‐based adhesive decreases wound healing time promotes...
Bioadhesives reduce operation time and surgical complications. However, in the presence of blood, adhesion strength is often compromised. Inspired by blood clotting activity snake venom, we report a visible light-induced blood-resistant hemostatic adhesive (HAD) containing gelatin methacryloyl reptilase, which hemocoagulase (HC) extracted from Bothrops atrox HAD leads to activation aggregation platelets efficiently transforms fibrinogen into fibrin achieve rapid hemostasis seal tissue. Blood...
Abstract Unhealed wound after malignant skin tumor resection, characterized by full‐thickness cutaneous defects, large open cavities, and incomplete tissue resection are the leading cause for long recovery times, poor prognoses, high recurrence among patients. Herein, a hyaluronic acid (HA)‐based microneedle (MN) functionalized with biomineralized melanin nanoparticles is fabricated to concurrently administer photothermal therapy (PTT) promote regeneration. Natural derived from cuttlefish...
Excessive extracellular matrix deposition drives fibroblasts into a state of high mechanical stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue dysfunction. This study reports minimally invasive convenient approach obtaining scarless using silk fibroin microneedle patch (SF MNs). We found that by tuning the MN size density only, biocompatible MNs significantly decreased elevation index in rabbit ear model increased ultimate tensile strength close...
Imaging-guided real-time monitoring of the treatment process inflammatory diseases is important for timely adjustment planning to lower unnecessary side effects and improve outcomes. However, it difficult reflect dynamic changes inflammation in vivo with enough tissue penetration depth. Here a novel nanotheranostic agent (denominated TMSN@PM) platelet membrane (PM)-coated, tempol-grafted, manganese-doped, mesoporous silica nanoparticles developed. The PM endows TMSN@PM ability target sites,...
Abstract Wounds infected with multidrug‐resistant (MDR) bacteria are increasingly threatening public health and challenging clinical treatments because of intensive bacterial colonization, excessive inflammatory responses, superabundant oxidative stress. To overcome this malignant burden promote wound healing, a multifunctional cryogel (HA/TA2/KR2) composed hyaluronic acid (HA), tannic (TA), KR‐12 peptides is designed. The exhibited excellent shape‐memory properties, strong absorption...
Thalassaemia is a good candidate disease for control by preventive genetic programmes in developing countries. Accurate population frequency data are needed planning the of thalassaemia high risk Guangdong Province southern China.In total, 13397 consecutive samples from five geographical areas were analysed both haematological and molecular parameters.There was prevalence carriers alpha (8.53%), beta (2.54%), (0.26%). Overall, 11.07% this area heterozygous thalassaemia. The mutation spectrum...
Appropriate RNAs are transcribed and amplified proteins expressed after transfection into cells of in vitro-reconstituted RNA-protein complexes infection with influenza virus as the helper. This system permits us to study signals involved transcription RNAs. For analysis we used a plasmid-derived RNA containing reporter gene for chloramphenicol acetyltransferase (CAT) flanked by noncoding sequences NS segment A/WSN/33 virus. Mutations were then introduced both 5' 3' ends, resulting studied...
The thermally healable polysiloxane elastomers were successfully prepared by cross-linking polydimethylsiloxane bearing maleimide pendants with furan-end functionalized siloxane via the Diels-Alder (DA) reaction. good mechanical properties show excellent self-healing and remoldability functions due to reversible feature of DA molecular mechanism was confirmed in situ structural characterization. Moreover, biocompatibility elastomer containing bonds is found be fairly cytotoxicity evaluation...
Impaired angiogenesis and bacterial infection have increasingly been implicated as the major causes of delayed diabetic wound healing.