A5103141295- Lanthanide and Transition Metal Complexes
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Iron oxide chemistry and applications
- MRI in cancer diagnosis
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Radiopharmaceutical Chemistry and Applications
- Dendrimers and Hyperbranched Polymers
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Bone and Joint Diseases
- Bone health and treatments
- interferon and immune responses
- Wound Healing and Treatments
- Surgical Sutures and Adhesives
- Carbon and Quantum Dots Applications
- Antimicrobial agents and applications
Shanghai Ninth People's Hospital
2017-2021
Shanghai Jiao Tong University
2017-2021
Anhui Medical University
2015-2020
Hefei University
2017
Tongji University
2011
Nanjing Second Hospital
2011
On-demand controlled miR-21-5p delivery system integrates immune modification and proangiogenesis assists MI therapy.
Incorporation of T1 and T2 contrast material in one nanosystem performing their respective MR role simultaneously serving as an efficient drug delivery system (DDS) has a significant potential application for clinical diagnosis chemotherapy cancer. However, inappropriate incorporation always encountered many issues, such low contact area with water-proton, distance between water molecule, undesirable disturbance imaging. Those issues seriously limited the or effect. In this work, we...
In this study, a high‐performance T 1 – 2 dual‐model contrast agent by gadolinium‐doped iron oxide nanoparticle (GION) is developed. Following its development, the application of in vivo combining doxorubicin (DOX) and folic acid (FA) (FA–GION–DOX) for targeted drug delivery to monitor cancer treatment explored. GION showed transverse longitudinal relaxivities up 182.7 × 10 −3 7.87 m −1 s , respectively, upon Gd/Fe ratio at 1/4. DOX released from FA–GION–DOX pH dependent only kills cell...
Current magnetic resonance imaging (MRI)-guided pH-switching therapeutic platforms have encountered problems such as low relaxation rates, poor efficiencies, and a lag in the drug release behind MRI. Herein, we designed nanoplatform with tunable pore size, which could match size of molecules for MRI chemotherapy via ultrasmall manganese oxide-capped mesoporous silica nanoparticles (USMO@MSNs). USMO@MSN quickly dissolve under weakly acidic conditions leach abundant Mn2+ ions (leaching ratio:...
Considering the chemical exchange between gadolinium centers and water protons, nanosystems comprising conjugated with high specific area nanocarriers might serve as more robust clinical tools for diagnosis imaging-guided therapy. Herein, a pH-responsive nanosystem containing graphene oxide folic acid- gadolinium-labeled dendrimer (FA-GCGLD) to boost its T1 contrast ability was developed, doxorubicin (DOX) colchicine (COLC) were efficiently loaded onto this (FA-GCGLD-DOX/COLC). This showed...
Magnetic resonance contrast agent employs the use of gadolinium chelates, which has many limitations for clinical including a low effect, short diagnostic window, and brief blood circulation time. On this basis, we designed gadolinium-labeled dendrimer nanocluster (GdDN) loaded graphene oxide nanosheet (GO-GdDN) to boost T1 ability imaging in vivo improve GO-GdDN presented an ultrahigh r1 relaxivity up 19.07 mM–1 s–1 9.4 T MR scanner, bright image vitro experiment. In addition, could be...
Zoledronic acid (ZOL) inhibits receptor activator of nuclear factor-κB ligand (RANKL) and reduces bone turnover. This plays an important role in the development bisphosphonate-related osteonecrosis jaw (BRONJ). Previous reports have shown that ZOL binds to enzyme farnesyl pyrophosphate synthase (FPPS) block its activity. However, mechanism action interaction with RANKL is still unclear. In this study, we confirmed significantly suppressed remodeling ZOL-treated rats, investigated whether...