Sulfonated (SO(3)H-bearing) activated carbon (AC-SO(3)H) was synthesized by an aryl diazonium salt reduction process. The obtained material had a SO(3)H density of 0.64 mmol·g-1 and specific surface area 602 m2·g-1. catalytic properties AC-SO(3)H were compared with that two commercial solid acid catalysts, Nafion NR50 Amberlyst-15. In 10-h esterification reaction acetic ethanol, the conversion (78%) lower than Amberlyst-15 (86%), which could be attributed to fact sulfonated (4.60 mmol·g-1)....

N6-methyladenosine (m6A) RNA modification plays a critical role in various physiological and pathological conditions. However, the of m6A head neck squamous cell carcinoma (HNSCC) remains elusive.In this study, expression demethylases was detected by HNSCC tissue microarray. m6A-RNA immunoprecipitation (MeRIP) sequencing were used to identify downstream targets ALKBH5. Comprehensive identification RNA-binding proteins mass spectrometry (ChIRP-MS) explore "readers". Tumor-infiltrating...

The crossmodal interaction of different senses, which is an important basis for learning and memory in the human brain, highly desired to be mimicked at device level developing neuromorphic perception, but related researches are scarce. Here, we demonstrate optoelectronic synapse vision-olfactory perception based on MXene/violet phosphorus (VP) van der Waals heterojunctions. Benefiting from efficient separation transport photogenerated carriers facilitated by conductive MXene, photoelectric...

Porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis (TGEV) are responsible for significant economic losses in the swine industry. The S1 proteins of these viruses serve as key targets vaccine development. In this study, prokaryotic expression vectors pCZN1-PEDV S1, pCZN1-TGEV S1-TGEV were constructed. corresponding expressed, purified, used to prepare monovalent, bivalent, mixed (PEDV + TGEV S1) vaccines. Kunming (KM) mice immunized with subunit vaccines, PBS negative...

Long intergenic noncoding RNA p21 (lincRNA-p21) is considered a target of wild-type p53, but little known about its regulation by mutant p53 and functions during the progression head neck squamous cell carcinoma (HNSCC). RNAscope was used to detect expression distribution lincRNA-p21. Chromatin immunoprecipitation electrophoretic mobility shift assays were performed analyze transcriptional lincRNA-p21 in HNSCC cells. The biological investigated vitro vivo. pull-down direct binding Lower...

Electrochromic displays with bistable color states provide a promising means toward transparent human–machine interfaces. However, the need for external power and weak optical modulation in visible light region of most electrochromic devices hinder their practical applications displays. Here we prepare MoO3–y/WO3–x films based on MoO3–y nanosheets, which show dark blue that matches response eye meets visual comfort standards compared to pure WO3–x film. By introducing highly Al3+ ion...

Abstract Although immunotherapy can prolong survival in some patients with head and neck squamous cell carcinoma (HNSCC), the response rate remains low. Clarification of critical mechanisms regulating CD8+ T-cell infiltration dysfunction tumor microenvironment could help maximize benefit for treating HNSCC. Here, we performed spatial transcriptomic analysis HNSCC specimens differing immune single-cell RNA sequencing five pairs adjacent tissues, revealing specific cancer-associated fibroblast...

Zinc oxide (ZnO) nanomaterials have attracted much attention in UV photodetectors owing to the suitable band gap and high photoelectric conversion efficiency. However, loose structure of assembled by a low-temperature process cannot meet mechanical requirements flexible photodetectors. The dark current caused defects ZnO severely drags down response performance To address these issues, we proposed novel strategy for constructing based on poly(ethylene glycol) (PEG) composites. Inspired...

Abstract Periodontal disease ranks third among noncommunicable illnesses, behind cancer and cardiovascular disease, is closely related to the occurrence progression of various systemic diseases. However, elucidating processes periodontal promoting bone regeneration remains a challenge. Here, quercetin demonstrated reduce oxidative stress state orofacial mesenchymal stem cells (OMSCs) in vitro affect osteogenic growth OMSCs through molecular mechanisms that mediate m6A change Per1....

Abstract Background Interferon alpha (IFNα) is a well-established regulator of immunosuppression in head and neck squamous cell carcinoma (HNSCC), while the role long noncoding RNAs (lncRNAs) remains largely unknown. Methods Differentially expressed lncRNAs were screened under IFNα stimulation using lncRNA sequencing. The mechanism investigated HNSCC vitro vivo. Results We identified novel IFNα-induced upregulated lncRNA, lncMX1–215, HNSCC. LncMX1–215 was primarily located nucleus. Ectopic...

Electrochromic technology plays a significant role in energy conservation, while its performance is greatly limited by the transport behavior of ions and electrons. Hence, an electrochromic system with overall excellent performances still need to be explored. Initially motivated high ionic electronic conductivity transition metal carbide or nitride (MXene), we design feasible procedure synthesize MXene/WO3-x composite film. The consequently boosted prove that addition MXene effective...

Histone lysine lactylation (Kla) is a post-translational modification, and its role in tumor immune escape remains unclear. Here, we find that increased histone associated with poor response to immunotherapy head neck squamous cell carcinoma (HNSCC). H3K9la identified as specific modification site HNSCC. Using cleavage under targets tagmentation analyses, interleukin-11 (IL-11) downstream regulatory gene of H3K9la. IL-11 transcriptionally activates checkpoint genes through JAK2/STAT3 signaling CD8

Electrochromic materials allow for optical modulation and have attracted much attention due to their bright future in applications such as smart windows energy-saving displays. Two-dimensional (2D) molybdenum oxide nanoflakes with combined advantages of high active specific surface area natural layered structure should be highly potential candidates electrochromic devices. However, the efficient top-down preparation 2D MoO3 is still a huge challenge sluggish ionic kinetics hinder its...

Abstract Background Metabolic reprograming and immune escape are two hallmarks of cancer. However, how metabolic disorders drive in head neck squamous cell carcinoma (HNSCC) remains unclear. Therefore, the aim present study was to investigate landscape HNSCC its mechanism driving escape. Methods Analysis paired tumor tissues adjacent normal from 69 patients performed using liquid/gas chromatography‐mass spectrometry RNA‐sequencing. The tumor‐promoting function kynurenine (Kyn) explored vitro...

Polycrystalline samples of Ce³⁺-doped NaBaBO₃ (0.5–15 mol%) were prepared by the solid-phase synthesis.

Eu3+-doped triple tellurium double perovskites LiBaLa[TeO6], NaBaLa[TeO6], LiBaBi[TeO6] and NaCaBi[TeO6] were synthesized by the general high temperature solid-state reaction. The crystal phase formations morphology of phosphates confirmed X-ray powder diffraction (XRD) scanning electron microscope (SEM) measurements, respectively. luminescence properties, including photoluminescence (PL) excitation emission spectra, decay curves (lifetimes), color coordinates internal quantum efficiency...

An immunosuppressive microenvironment is critical for cancer initiation and progression. Whether interferon alpha (IFNα) can suppress immune cells its involved mechanism still remain largely elusive. We examine the expression of alpha/beta receptor-1 (IFNAR1), CD8, CD56 programmed death ligand 1 (PDL1) in head neck squamous cell carcinomas (HNSCC). The effect IFNα on PDL1 protein (PD1) tumour was detected vitro vivo. Overexpression IFNAR1, MX1 signal transducer activator transcription...

Abstract The regulation of carrier generation and transport by Schottky junctions enables effective optoelectronic conversion in devices. A simple general strategy to spontaneously generate photocurrent is great significance for self‐powered photodetectors but still being pursued. Here, we propose that a can be induced at zero bias the transmittance contrast MXene electrodes MXene/semiconductor junctions. Two with large (84%) between thin thick zones were deposited on surface semiconductor...

Natural polymer substrates are gaining attention as substitutes for plastic in electronics, aiming to combine high performance, intricate shape deformation, and environmental sustainability. Herein, natural wood veneer is converted into a transparent film (TWF) substrate. The combination of 3D printing origami technique established create programmable wood-based which exhibit superior flexibility with tensile strength (393 MPa) due the highly aligned cellulose fibers formation numerous...