A5060980796- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
Shanghai Ninth People's Hospital
2023
Shanghai Jiao Tong University
2023
National Clinical Research Center for Digestive Diseases
2023
Stomatology Hospital
2023
Abstract Although immunotherapy can prolong survival in some patients with head and neck squamous cell carcinoma (HNSCC), the response rate remains low. Clarification of critical mechanisms regulating CD8+ T-cell infiltration dysfunction tumor microenvironment could help maximize benefit for treating HNSCC. Here, we performed spatial transcriptomic analysis HNSCC specimens differing immune single-cell RNA sequencing five pairs adjacent tissues, revealing specific cancer-associated fibroblast...
<p>This file includes Figure S1-S8 and their figure legends.</p>
<p>This file includes Figure S1-S8 and their figure legends.</p>
<div>Abstract<p>Although immunotherapy can prolong survival in some patients with head and neck squamous cell carcinoma (HNSCC), the response rate remains low. Clarification of critical mechanisms regulating CD8<sup>+</sup> T-cell infiltration dysfunction tumor microenvironment could help maximize benefit for treating HNSCC. Here, we performed spatial transcriptomic analysis HNSCC specimens differing immune single-cell RNA sequencing five pairs adjacent tissues,...
<div>Abstract<p>Although immunotherapy can prolong survival in some patients with head and neck squamous cell carcinoma (HNSCC), the response rate remains low. Clarification of critical mechanisms regulating CD8<sup>+</sup> T-cell infiltration dysfunction tumor microenvironment could help maximize benefit for treating HNSCC. Here, we performed spatial transcriptomic analysis HNSCC specimens differing immune single-cell RNA sequencing five pairs adjacent tissues,...