All drugs for cancer therapy face several transportation barriers on their tortuous journey to the action sites. To overcome these barriers, an effective drug delivery system is imperative. Here, we develop a self-delivery therapy, in which anticancer can be delivered by themselves without any carriers. demonstrate this unique approach, amphiphilic drug-drug conjugate (ADDC) has been synthesized from hydrophilic irinotecan (Ir) and hydrophobic chlorambucil (Cb) via hydrolyzable ester...

Abstract Hyperbranched polymers (HBPs) are highly branched macromolecules with a three‐dimensional dendritic architecture. Due to their unique topological structure and interesting physical/chemical properties, HBPs have attracted wide attention from both academia industry. In this paper, the recent developments in HBP self‐assembly biomedical applications been comprehensively reviewed. Many delicate supramolecular structures zero‐dimension (0D) three‐dimension (3D), such as micelles,...

A linear-hyperbranched supramolecular amphiphile was synthesized through the noncovalent coupling of adamantane-functionalized long alkyl chain (AD-Cn, n = 12, 18, 30) and hyperbranched polyglycerol grafted from β-cyclodextrin (CD-g-HPG) by specific AD/CD host–guest interactions. The obtained Cn-b-HPGs self-assembled into unilamellar vesicles with great ductility that could be disassembled readily under a competitive host β-CD.

Rechargeable aqueous Zn-ion batteries (ZIBs) are regarded as one of the most promising devices for next-generation energy storage system. However, uncontrolled dendrite growth on Zn metal anodes and side hydrogen evolution reaction, which has not yet been well considered, hinder practical application these batteries. Herein, a uniform robust metallic Sb protective layer is designed based theoretic calculation decorated plate via in situ replacement reaction. Compared with bare plate,...

Rechargeable aqueous zinc-ion batteries (ZIBs) have attracted extensive attention due to their low cost and high safety. However, the critical issues of dendrite growth side reactions on Zn metal anode hinder commercialization ZIBs. Herein, we demonstrated that formation Zn4SO4(OH)6·5H2O byproducts is closely relevant direct contact between electrode SO42-/H2O. On basis this finding, developed a cation-exchange membrane perfluorosulfonic acid (PFSA) coated surface regulate plating/stripping...

An artificial SEI film based on Zn-intercalated montmorillonite was designed to tune the deposition behaviour of Zn²⁺ ions surface Zn anode.

Abstract Construction of polymer‐based artificial solid‐electrolyte interphase films on Zn metal anode holds great potential in the suppression both dendrite growth and side reaction rechargeable aqueous Zn‐ion batteries. However, traditional polymer suffer from critical issues sluggish 2+ transport kinetics rigid interface. Herein, zinc alginate (ZA) hydrogel is designed prepared as a dynamic interface redistributor via situ cross‐linking reaction. The zincophilic negatively charged...

Clinical and experimental evidence confirmed bacterial infiltration in a variety of tumors, which is related to the progression therapeutic effects tumors. Although administration antibiotics inhibits growth bacteria inside tumor, systemic distribution induces an imbalance other microbiomes body, turn leads development new diseases. To address this clinical challenge, we nanonized antibiotic study. Metronidazole, against broad anaerobes, was linked fluorouridine form amphiphilic small...

In this work, the authors proposed desolvation activation energy as a critical descriptor for screening of electrolyte additives, establishing correlation between polarization and energy.

Abstract Piezoelectric actuators are a class of that precisely transfer input electric energy into displacement, force, or movement outputs efficiently via inverse piezoelectric effect-based electromechanical coupling. Various types have sprung up and gained widespread use in various applications terms compelling attributes, such as high precision, flexibility stoke, immunity to electromagnetic interference, structural scalability. This paper systematically reviews the materials, operating...

Abstract Developing artificial protective layers is an effective strategy to address the issue of dendrites for aqueous Zn‐metal batteries (ZMBS). However, drawbacks such as rough microscopic morphology, excessive thickness, and single functionality remain, limiting attainment a stable zinc anode. Herein, novel multifunctional organic–inorganic hybrid layer produced by splicing inorganic fragments onto organic materials in situ using chemical sewing. The well‐compatible also retains function...

Abstract Photodynamic therapy (PDT) holds significant promise for antibacterial treatment, with its potential markedly amplified when using Type I photosensitizers (PSs). However, developing PSs remains a challenge due to lack of reliable design strategy. Herein, PS nanocluster is developed via self‐assembly zwitterionic small molecule (C3TH) superior PDT in vivo. Mechanism studies demonstrate that unique cross‐arranged C3TH within not only shortens intermolecular distance but also inhibits...

Novel redox-responsive polyphosphate nanosized assemblies based on amphiphilic hyperbranched multiarm copolyphosphates (HPHSEP-star-PEP(x)) with backbone redox-responsive, good biocompatibility, and biodegradability simultaneously have been designed prepared successfully. The hydrophobic core hydrophilic of HPHSEP-star-PEP(x) are composed linear polyphosphates, respectively. Benefiting from the amphiphilicity, can self-assemble into spherical micellar nanoparticles in aqueous media tunable...

A new type of biodegradable micelles for glutathione-mediated intracellular drug delivery was developed on the basis an amphiphilic hyperbranched multiarm copolymer (H40-star-PLA-SS-PEP) with disulfide linkages between hydrophobic polyester core and hydrophilic polyphosphate arms. The resulting copolymers were characterized by nuclear magnetic resonance (NMR), Fourier transformed infrared (FTIR), gel permeation chromatography (GPC), differential scanning calorimeter (DSC) techniques....

This study provided a facile and green method to prepare stable colloid silver nanoparticles in aqueous solution by utilizing the amine-terminated hyperbranched poly(amidoamine) (HPAMAM-NH2) as both stabilizer reductant. The formation of was verified FTIR, UV−vis, TEM, EDS, XRD measurements. Monodispersed with small particle sizes were obtained, average size could be effectively controlled from ca. 15 4 nm simply adjusting molar ratio N/Ag feed. antibacterial activity HPAMAM-NH2/Ag...

Chemotherapy is an important modality in cancer treatment. The major challenge of recent works this research field to develop new types smart nanocarriers that can respond selectively cell-specific conditions and realize rapid drug release target cells. In the present study, a reactive oxygen species-responsive nanocarrier has been successfully self-assembled from amphiphilic hyperbranched polymer consisting alternative hydrophobic selenide groups hydrophilic phosphate segments dendritic...

Currently, the major challenge for cancer treatment is to develop new types of smart nanocarriers that can efficiently retain encapsulated drug during blood circulation and quickly release in tumor cells under stimulation. In this study, dual pH-/light-responsive cross-linked polymeric micelles (CPM) were successfully prepared by self-assembly amphiphilic glycol chitosan-o-nitrobenzyl succinate conjugates (GC-NBSCs) then cross-linking with glutaraldehyde (GA), which was synthesized grafting...

ABSTRACT Polyimides are a class of well‐known high‐performance polymers combined the excellent mechanical, electrical, and thermal properties widely applied in many high‐tech fields. Traditional polyimides can only be processed state soluble intermediates with hazardous step cyclodehydration elimination nonvolatile polar solvent. Therefore, great effort has been devoted to development that full imidation state. The incorporation side groups into polyimide backbone is an efficient approach...

The combination of chemotherapy and photodynamic therapy (PDT) based on nanoparticles (NPs) has been extensively developed to improve the therapeutic effect decrease systemic toxicity current treatments. However, overexpressed glutathione (GSH) in tumor cells efficiently scavenges singlet oxygens (1O2) generated from photosensitizers results unsatisfactory efficacy PDT. To address this obstacle, here we design H2O2-responsive polymer prodrug NPs with GSH-scavenger (Ce6@P(EG-a-CPBE) NPs) for...