A5079431213- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Corneal Surgery and Treatments
- Polymer Surface Interaction Studies
- Ocular Surface and Contact Lens
- Hydrogels: synthesis, properties, applications
- Immunotherapy and Immune Responses
- Advanced Drug Delivery Systems
- Cancer Research and Treatments
- Bacteriophages and microbial interactions
- Bone health and treatments
- Graphene and Nanomaterials Applications
- Analytical Chemistry and Chromatography
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Advanced Sensor and Energy Harvesting Materials
- Supramolecular Self-Assembly in Materials
- Gut microbiota and health
- Microfluidic and Capillary Electrophoresis Applications
- Monoclonal and Polyclonal Antibodies Research
- Biochemical and Structural Characterization
Shanghai Ninth People's Hospital
2019-2025
Shanghai Jiao Tong University
2012-2025
Northwestern Polytechnical University
2025
National University of Singapore
2022-2024
Central South University of Forestry and Technology
2009-2024
Guilin University
2024
Central South University
2019-2024
Fifth Hospital In Wuhan
2024
Wuhan University
2024
Chengdu Women's and Children's Central Hospital
2024
The recent progress in synthesis, properties and biomedical applications of supramolecular hydrogels has been reviewed.
Abstract The gut microbiota represents a huge community of microorganisms that play essential roles in immune modulation and homeostasis maintenance. Microbiota transplantation is an important approach to prevent treat disease as it can inhibit pathogen colonization positively modulate bacterial composition. However, the development oral therapeutics has been restricted by low bioavailability limited retention gastrointestinal tract. Here, we report simple yet highly efficient method coat...
Abstract Bacteria have been extensively utilized for bioimaging, diagnosis and therapy given their unique characteristics including genetic manipulation, rapid proliferation disease site targeting specificity. However, clinical translation of bacteria these applications has largely restricted by unavoidable side effects low treatment efficacies. Engineered biomedical ideally need to generate only a inflammatory response, show slow elimination macrophages, accumulation in normal organs,...
Abstract Surface decoration of living cells by exogenous substances offers a unique tool for understanding and tuning cell behaviors, which plays critical role in cell‐based therapy. Here, facile yet versatile approach decorating individual with multimodal coatings is reported. By simply co‐depositing dopamine under cytocompatible condition, various functional small molecules polymers can be encoded to form multifunctional coating on cell's surface. The accessibility versatility this method...
Abstract The skin is intrinsically a cell-membrane-compartmentalized hydrogel with high mechanical strength, potent antimicrobial ability, and robust immunological competence, which provide multiple protective effects to the body. Methods capable of preparing hydrogels that can simultaneously mimic structure function are highly desirable but have been proven be challenge. Here, dual structurally functionally skin-mimicking generated by crosslinking cell-membrane compartments. crosslinked...
Oxime bonds dispersed in the backbones of synthetic polymers, while young current spectrum biomedical application, are rapidly extending into their own niche. In present work, oxime linkages were confirmed to be a robust tool for design pH-sensitive polymeric drug delivery systems. The triblock copolymer (PEG-OPCL-PEG) consisting hydrophilic poly(ethylene glycol) (PEG) and hydrophobic oxime-tethered polycaprolactone (OPCL) was successfully prepared by aminooxy terminals OPCL ligating with...
Novel redox-responsive polyphosphate nanosized assemblies based on amphiphilic hyperbranched multiarm copolyphosphates (HPHSEP-star-PEP(x)) with backbone redox-responsive, good biocompatibility, and biodegradability simultaneously have been designed prepared successfully. The hydrophobic core hydrophilic of HPHSEP-star-PEP(x) are composed linear polyphosphates, respectively. Benefiting from the amphiphilicity, can self-assemble into spherical micellar nanoparticles in aqueous media tunable...
A new type of biodegradable micelles for glutathione-mediated intracellular drug delivery was developed on the basis an amphiphilic hyperbranched multiarm copolymer (H40-star-PLA-SS-PEP) with disulfide linkages between hydrophobic polyester core and hydrophilic polyphosphate arms. The resulting copolymers were characterized by nuclear magnetic resonance (NMR), Fourier transformed infrared (FTIR), gel permeation chromatography (GPC), differential scanning calorimeter (DSC) techniques....
Novel supramolecular copolymer micelles with stimuli-responsive abilities were successfully prepared through the complementary multiple hydrogen bonds of nucleobases and then applied for rapid intracellular release drugs. First, both adenine-terminated poly(ε-caprolactone) (PCL-A) uracil-terminated poly(ethylene glycol) (PEG-U) synthesized. The amphiphilic block copolymers (PCL-A:U-PEG) formed based on bonding interactions between PCL-A PEG-U. self-assembled from PCL-A:U-PEG sufficiently...
Systems capable of residing for prolonged periods time in the gastric cavity have transformed our ability to diagnose and treat patients. Gastric resident systems drug delivery, ideally need be: ingestible, be able change shape or swell ensure residence, mechanical integrity withstand forces associated with gastrointestinal motility, triggerable address any side effects, loadable release over a period time. Materials that been primarily utilized these applications largely restricted...
Chemotherapy is an important modality in cancer treatment. The major challenge of recent works this research field to develop new types smart nanocarriers that can respond selectively cell-specific conditions and realize rapid drug release target cells. In the present study, a reactive oxygen species-responsive nanocarrier has been successfully self-assembled from amphiphilic hyperbranched polymer consisting alternative hydrophobic selenide groups hydrophilic phosphate segments dendritic...
Abstract Biological tissues, such as muscle, can increase their mechanical strength after swelling due to the existence of many biological membrane barriers that regulate transmembrane transport water molecules and ions. Oppositely, typical synthetic materials show a swelling-weakening behavior, which always suffers from sharp decline in swelling, because dilution network. Here, we describe swelling-strengthening phenomenon polymer achieved by bioinspired strategy. Liposomal nanobarriers are...
Abstract Disorders in the gut microbiota have been implicated various diseases, such as inflammatory bowel diabetes, and cancers. Oral microecologics are of great importance due to their ability directly intervene microbiome well noninvasiveness low side effects, while suffered from bioavailability a single therapeutic effect. Here, probiotics coated with nanocoating for synergistically enhanced biotherapy, method inspired by robust protective effectiveness silkworm cocoon. With its...
The best of both worlds: A novel amphiphilic homopolymer synthesized from a monomer consisting hydrophobic group (see picture, red) and hydrophilic moiety (green) self-assembles in aqueous solution. resulting micelles have multi-core/shell structure exhibit smart redox-responsive properties, thus providing favorable drug delivery platform for cancer therapy. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not...
A water-soluble hyperbranched polyphosphate (HPHEEP) was synthesized through the self-condensation ring-opening polymerization (SCROP) of 2-(2-hydroxyethoxy)ethoxy-2-oxo-1,3,2-dioxaphospholane (HEEP), and its suitability as a drug carrier then evaluated in vitro. Methyl tetrazolium (MTT) live/dead staining assays indicated that HPHEEP had excellent biocompatibility against COS-7 cells. The good biodegradability observed by NMR analysis, degradation products were nontoxic to Flow cytometry...
Hyperbranched poly(amido amine)s (HPAAs) containing different amounts of β-cyclodextrin (β-CD) (HPAA-CDs) were synthesized in one-pot by Michael addition copolymerization N,N'-methylene bisacrylamide, 1-(2-aminoethyl)piperazine, and mono-6-deoxy-6-ethylenediamino-β-CD. In comparison to pure HPAA, the fluorescence intensity HPAA-CDs was enhanced significantly while cytotoxicity became lower. Ascribed plenty amino groups strong photoluminescence, could be used as nonviral gene delivery...
The hydrophobic block of polymeric micelles formed by amphiphilic copolymers has no direct therapeutical effect, and the metabolites these segments might lead to some unexpected side effects. Here core is replaced highly water-insoluble drugs themselves, forming a new micellar drug delivery system. By grafting paclitaxel (PTX) onto surface hydrophilic hyperbranched poly(ether-ester) (HPEE), we constructed an copolymer (HPEE-PTX). HPEE-PTX could self-assemble into nanoparticles in aqueous...