A5052733324- Biofuel production and bioconversion
- Microbial Metabolic Engineering and Bioproduction
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- MicroRNA in disease regulation
- Microbial metabolism and enzyme function
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Oral health in cancer treatment
- Circular RNAs in diseases
- Polysaccharides Composition and Applications
- Lignin and Wood Chemistry
- Immune Cell Function and Interaction
- 3D Printing in Biomedical Research
- Ferroptosis and cancer prognosis
- Advanced Drug Delivery Systems
- Cancer Diagnosis and Treatment
- Fungal and yeast genetics research
- Advanced Cellulose Research Studies
- Mineral Processing and Grinding
- Vagus Nerve Stimulation Research
- Extraction and Separation Processes
- Colorectal Cancer Treatments and Studies
- Fluid Dynamics and Mixing
- HIV Research and Treatment
Tongji University
2022-2025
Renji Hospital
2021-2025
Shanghai Jiao Tong University
2021-2025
Shanghai Cancer Institute
2021-2025
Changhai Hospital
2025
Second Military Medical University
2025
Shanghai Tenth People's Hospital
2022-2025
University of Macau
2025
State Key Laboratory of Medical Neurobiology
2023-2024
Huashan Hospital
2023-2024
Abstract Surface decoration of living cells by exogenous substances offers a unique tool for understanding and tuning cell behaviors, which plays critical role in cell‐based therapy. Here, facile yet versatile approach decorating individual with multimodal coatings is reported. By simply co‐depositing dopamine under cytocompatible condition, various functional small molecules polymers can be encoded to form multifunctional coating on cell's surface. The accessibility versatility this method...
Methods capable of maintaining gut microbiota homeostasis to prevent bacterial translocation and infection under external threats are critical for multiple facets human health but have been rarely reported. Here, we describe the elicitation mucosal immunity modulate by oral delivery living probiotics into Peyer's patches. Probiotics individually camouflaged within a yeast membrane, on which embedded β-glucan can facilitate phagocytosis microfold cells that locate in intestinal epithelium....
Abstract Disorders in the gut microbiota have been implicated various diseases, such as inflammatory bowel diabetes, and cancers. Oral microecologics are of great importance due to their ability directly intervene microbiome well noninvasiveness low side effects, while suffered from bioavailability a single therapeutic effect. Here, probiotics coated with nanocoating for synergistically enhanced biotherapy, method inspired by robust protective effectiveness silkworm cocoon. With its...
Despite immunosuppression is critical for reducing immune overactivation, existing immunosuppressive agents are largely restricted by low inhibition efficiencies and unpredictable off-target toxicities. Here, the use of dopaminergic system reported to suppress hyperactive responses in local inflamed tissues. A polydopamine nanoparticular immunosuppressant (PDNI) synthesized stimulate regulatory T (Treg) cells directly inhibit helper 1 (Th1), Th2, Th17 cells. Moreover, PDNI can activation...
Autism spectrum disorder (ASD) is a complex behavioral diagnosed by social interaction difficulties, restricted verbal communication, and repetitive behaviors. Fecal microbiota transplantation (FMT) safe efficient strategy to adjust gut dysbiosis improve ASD-related symptoms, but its regulatory mechanism unknown. The impact of the functions on ASD development urgently being investigated develop new therapeutic strategies for ASD. We reconstituted valproic acid (VPA)-induced autism mouse...
Abstract Accumulating evidence indicates long noncoding RNAs (lncRNA) play a vital role in tumor progression. However, the of linc00645-induced accelerated malignant behavior glioblastoma (GBM) remains unknown. In present study, linc00645 expression was significantly upregulated GBM tissues and cell lines. High level associated with poor overall survival patients. Knockdown suppressed proliferation, stemness, migration, invasion, reversed transforming growth factor (TGF)-β-induced motility...
Rationale: Fecal microbiota transplantation (FMT) is advantageous for treating intractable diseases via the microbiota-gut-organ axis. However, invasive administration of gut nasal feeding tubes limits widespread application FMT. Here, we attempted to develop a novel strategy deliver using nanocapsules. Methods: Single-cell nanocapsules were fabricated within 1 h by layer-by-layer assembly silk fibroin and phosphatidylcholine generate protective nanoshell on cell surface complicated...
High product concentration in aerobic biorefining fermentation requires high lignocellulose feedstock loading. However, the solids content and consequent viscosity of hydrolysate severely limit oxygen transfer thus lead to low rate. This study first investigates experimental measurement computational fluid dynamics (CFD)-based simulation properties loading highly viscous hydrolysates. The mass coefficients kLa values vary with various processing parameters. A minimum threshold value was...
Accumulation of intracellular lipid bodies in oleaginous yeast cells is highly restricted by their natural space. Here we show a cellulase mediated adaptive evolution with ultra-centrifugation fractionation Trichosporon cutaneum to obtain the favorable cell structure for accumulation. Cellulase was added wheat straw hydrolysate during long-term disruption wall integrity T. cells. The cellulase, together ultracentrifugation force, triggered multiple mutations and transcriptional expression...
As with many diseases, tumor formation in colorectal cancer (CRC) is multifactorial and involves immune, environmental factors various genetics that contribute to disease development. Accumulating evidence suggests the gut microbiome linked occurrence development of CRC, these microorganisms are important for immune maturation. However, a systematic perspective integrating microbial profiling, T cell receptor (TCR) somatic mutations humans CRC lacking. Here, we report distinct features...
Microbial lipid production from lignocellulose biomass provides an essential option for sustainable and carbon-neutral supply of future aviation fuels, biodiesel, as well various food nutrition products. Oleaginous yeast is the major microbial cell factory but its lipid-producing performance far below requirements industrial application. Here we show ultra-centrifugation fractionation in adaptive evolution (UCF) Trichosporon cutaneum based on minor density difference. The lightest cells with...
Abstract Objective As a single‐transmembrane protein of the FXYD family, FXYD6 plays different roles under physiological and pathological status, especially in nervous system. This study aims to identify as biomarker for glioma, by analyzing its expression methylation patterns. Methods Using TCGA GTEx datasets, we analyzed various tissues, confirming levels normal brain glioma grades via immunoblotting immunostaining. biological functions were explored through enrichment analysis, tumor...