A5044269604- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer Research and Treatments
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Genetic Associations and Epidemiology
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Angiogenesis and VEGF in Cancer
- Quinazolinone synthesis and applications
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Meningioma and schwannoma management
- Garlic and Onion Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Nephrotoxicity and Medicinal Plants
- Single-cell and spatial transcriptomics
The First Affiliated Hospital, Sun Yat-sen University
2025
Sun Yat-sen University
2025
Third Affiliated Hospital of Harbin Medical University
2013-2024
Harbin Medical University
2013-2024
First Affiliated Hospital of Guangzhou Medical University
2023-2024
State Key Laboratory of Respiratory Disease
2023-2024
Guangzhou Medical University
2023-2024
Jingdezhen University
2024
Xian Yang Central Hospital
2024
Jiangxi Science and Technology Normal University
2018
Accumulating evidence demonstrates the oncogenic roles of lncRNA (long non-coding RNA) molecules in a wide variety cancer types including glioma. Equally important, However, tumorigenic functions glioma remain largely unclear. A recent study suggested SNHG15 played role for regulating angiogenesis but its tumor microenvironment (TME) was not investigated.First, we showed that upregulated GBM cells and associated with poor prognosis patients using public databases. Next, collected...
Abstract Accumulating evidence indicates long noncoding RNAs (lncRNA) play a vital role in tumor progression. However, the of linc00645-induced accelerated malignant behavior glioblastoma (GBM) remains unknown. In present study, linc00645 expression was significantly upregulated GBM tissues and cell lines. High level associated with poor overall survival patients. Knockdown suppressed proliferation, stemness, migration, invasion, reversed transforming growth factor (TGF)-β-induced motility...
Allicin is an extract purified from Allium sativum (garlic), and previous research has indicated that inhibitory effect on many kinds of tumor cells. The aim the present study was to explore anticancer activity human glioma cells investigate underlying mechanism. MTT colony-formation assays were performed detect cell proliferation, at various doses time-points. apoptosis measured by fluorescence microscopy with Hoechst 33258 staining, then flow cytometry used analyzed changes in apoptosis....
Patients with non-small cell lung cancer (NSCLC) initially responding to tyrosine kinase inhibitors (TKIs) eventually develop resistance due accumulating mutations in the EGFR and additional lesser investigated mechanisms such as participation of tumor microenvironment (TME).Here, we examined potential for MET inhibitor capmatinib treatment osimertinib-resistant NSCLCs normalizing TME.We first established that HCC827 H1975 cells showed increased against osimertinib when co-cultured CAFs...
Human fetal neural stem cells (hNSCs) are used to treat a variety of neurological disorders involving spinal cord injury (SCI). Although their mechanism action has been attributed cell substitution, we examined the possibility that NSCs may have neuroprotective activities. The present article studied hNSCs on protecting neurons and promoting corticospinal tract (CST) axon regeneration after SCI. were isolated from cortical tissue spontaneously aborted human fetuses. removed NSC culture...
Glioblastoma multiforme (GBM) is one of the most aggressive tumors in central nervous system. SEMA6A, first identified class 6 semaphorin, contributed to regulate vascular development and adult angiogenesis. However, function SEMA6A GBM still undefined. In present study, we investigated expression protein 200 tissues using immunohistochemistry (IHC). was associated with time progression (P = 0.001) mean tumor diameter 0.038). Kaplan–Meier analysis revealed that patients expressing high...
Increasing evidence indicates that glioma topographic location is linked to the cellular origin, molecular alterations and genetic profile. This research aims (a) reveal underlying mechanisms of tumor predilection in glioblastoma multiforme (GBM) lower-grade (LGG) (b) leverage features predict prognosis. MRI images from 396 GBM 190 LGG (115 astrocytoma 75 oligodendroglioma) patients were standardized construct frequency maps analyzed by voxel-based lesion-symptom mapping. We then...
Abstract Purpose Lung cancer (LC) and breast (BC) are the most common causes of brain metastases (BMs). Time from primary diagnosis to BM (TPDBM) refers time interval between initial LC or BC development BM. This research aims identify clinical, molecular, therapeutic risk factors associated with shorter TPDBM. Methods We retrospectively reviewed all diagnosed patients at Harbin Medical University Cancer Hospital 2016 2020. A total 570 metastasis (LCBM) 173 (BCBM) who met inclusion criteria...
Gliomas are primary brain tumors and among the most malignant types. Adult-type diffuse gliomas can be classified based on their histological molecular signatures as IDH-wildtype glioblastoma, IDH-mutant astrocytoma, 1p/19q-codeleted oligodendroglioma. Recent studies have shown that each subtype of glioma has its own specific distribution pattern. However, mechanisms underlying distributions subtypes not entirely clear despite partial explanations such cell origin. To investigate impact...
Isocitrate dehydrogenase-wildtype glioblastoma (IDH-wildtype GBM) and IDH-mutant astrocytoma have distinct biological behaviors clinical outcomes. The location of brain tumors is closely associated not only with symptoms prognosis but also key molecular alterations such as IDH. Therefore, we hypothesize that the regions influencing are likely to differ. This study aims (1) identify specific Karnofsky Performance Scale (KPS) or overall survival (OS) in IDH-wildtype GBM (2) test whether...
Studies investigating possible associations between cytochrome P4501B1 (CYP1B1) polymorphisms and breast cancer risk have been inconsistent. We set out to ascertain whether there might be an association in exon 2 (codon 119, G-->T) 3 432, G-->C) of CYP1B1 a Chinese Han population the rural region Ningxia. Using allele-specific polymerase chain reaction method direct DNA sequencing, presence or absence two was investigated. Genotype allele frequencies were analyzed cases (n = 152) healthy...
This study aimed to investigate the use of radiomics features and clinical information by four machine learning algorithms for predicting prognosis patients with hepatocellular carcinoma (HCC) who have been treated transarterial chemoembolization (TACE).
Palmitoylation, a key post-translational modification, plays significant role in ovarian cancer (OV) progression. However, the impact of palmitoylation-related genes on genomic instability, immune infiltration, and therapeutic response OV remains poorly understood. This study aimed to investigate these factors facilitate risk stratification intervention, providing insights into personalized treatment strategies.
To investigate the expression status of Girdin in glioma and relationship between biological behavior glioma.The from 560 cases was evaluated by RT-PCR, Western Blot immunohistochemistry. The clinic-pathological parameters as well prognosis also studied.The high grade significantly higher than low glioma. After universal analysis, protein is closely related to KPS score, extent resection, Ki67 WHO grade, but it not sex age. Finally, were indentified be logistic regression. Interestingly, we...
Even after multimodal therapy, the prognosis is dismal for patients with brain metastases from non-small cell lung cancer (NSCLC). Although blood-brain barrier (BBB) limits tumor penetration into parenchyma, some nevertheless colonize tissue through mechanisms that are not fully clear. Here we show homeobox B9 (HOXB9), which commonly overexpressed in NSCLC, promotes epithelial-to-mesenchymal transition (EMT) and migration invasion. Animal experiments showed HOXB9 expression correlates...
Previous studies suggested that dopamine receptors may be associated with drug dependence and impulsive behavior.In this study, we examined whether receptor D1 (DRD1) is heroin the behavior in patients dependence.The participants included 367 372 healthy controls from a Chinese Han population.We potential association between 8 single-nucleotide polymorphisms (rs686, rs4867798, rs1799914, rs4532, rs5326, rs265981, rs10078714, rs10078866) of DRD1, associations single polymorphism, haplotypes,...