A5046159003- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Ginger and Zingiberaceae research
- Advanced Neuroimaging Techniques and Applications
- Gut microbiota and health
- Neural dynamics and brain function
- Biochemical and biochemical processes
- Radiomics and Machine Learning in Medical Imaging
- Traumatic Brain Injury Research
- Neuroscience and Neuropharmacology Research
- Cerebrospinal fluid and hydrocephalus
- Single-cell and spatial transcriptomics
- Functional Brain Connectivity Studies
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Sirtuins and Resveratrol in Medicine
- Atherosclerosis and Cardiovascular Diseases
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
Wannan Medical College
2024
Harbin Medical University
2020-2023
First Affiliated Hospital of Harbin Medical University
2020-2023
Increasing evidence indicates that glioma topographic location is linked to the cellular origin, molecular alterations and genetic profile. This research aims (a) reveal underlying mechanisms of tumor predilection in glioblastoma multiforme (GBM) lower-grade (LGG) (b) leverage features predict prognosis. MRI images from 396 GBM 190 LGG (115 astrocytoma 75 oligodendroglioma) patients were standardized construct frequency maps analyzed by voxel-based lesion-symptom mapping. We then...
Abstract Background Cortical and subcortical microstructural modifications are critical to understanding the pathogenic changes in frontotemporal lobar degeneration (FTLD) subtypes. In this study, we investigated cortical microstructure underlying cognitive language impairments across behavioral variant of dementia (bvFTD), semantic primary progressive aphasia (svPPA), nonfluent (nfvPPA) Methods The current study characterized 170 individuals with 3 T MRI structural diffusion-weighted...
Nucleus basalis of Meynert (NbM), one the earliest targets Alzheimer's disease (AD), may act as a seed for pathological spreading to its connected regions. However, underlying basis regional vulnerability NbM dysconnectivity remains unclear. functional was assessed using resting-state fMRI data health controls and mild cognitive impairment (MCI) patients from Neuroimaging Initiative (ADNI2/GO phase). Transcriptional correlates explored by leveraging public intrinsic differential post-mortem...
Abstract Background: Cortical and subcortical microstructural modifications are critical to understanding the pathogenic changes in frontotemporal lobar degeneration (FTLD) subtypes. In this study, we investigated cortical microstructure underlying cognitive language impairments across behavioral variant of dementia (bvFTD), semantic primary progressive aphasia (svPPA), nonfluent (nfvPPA) Methods: The current study characterized 170 individuals with 3T MRI structural diffusion-weighted...
Abstract Background: Intestinal microbiota and amino acids that are one of their metabolites play important roles in the mechanism pathology Parkinson's disease (PD). It has been reported level vivo participate neurodegeneration by regulating adaptive immune response, while current researches on alteration intestinal still insufficient. Here, we evaluate correlation between gut alterations clinical parameters PD, acid concentrations. Methods: Stool samples from PD healthy controls were...