A5050724481- Metabolomics and Mass Spectrometry Studies
- Air Quality and Health Impacts
- Dendrimers and Hyperbranched Polymers
- Nanoparticles: synthesis and applications
- RNA Interference and Gene Delivery
- Advanced Polymer Synthesis and Characterization
- Advanced biosensing and bioanalysis techniques
- Supramolecular Chemistry and Complexes
- Climate Change and Health Impacts
- Luminescence and Fluorescent Materials
- Thin-Film Transistor Technologies
- Nanoparticle-Based Drug Delivery
- Semiconductor materials and devices
- Energy and Environment Impacts
- Quantum Dots Synthesis And Properties
- Advanced Nanomaterials in Catalysis
- Bone Tissue Engineering Materials
- Analytical Chemistry and Chromatography
- Ferroelectric and Piezoelectric Materials
- Vehicle emissions and performance
- Catalysis and Oxidation Reactions
- Selenium in Biological Systems
- Covalent Organic Framework Applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Immune Cell Function and Interaction
Nanjing Medical University
2024
People's Hospital of Xinjiang Uygur Autonomous Region
2023
Karlsruhe Institute of Technology
2023
Shanghai Jiao Tong University
2010-2022
Nanotitanium dioxide (TiO2) is an important industrial material that widely used as additive in cosmetics, pharmaceuticals, and food colorants. Although the small size of TiO2 nanoparticle useful various applications, biosafety this needs to be evaluated. In study, mouse fibroblast (L929) cells were evaluate cytotoxicity different concentrations (3−600 μg/mL) homogeneous weakly aggregated nanoparticles aqueous solution. The L929 became round even shrank concentration increased. Moreover,...
Novel supramolecular copolymer micelles with stimuli-responsive abilities were successfully prepared through the complementary multiple hydrogen bonds of nucleobases and then applied for rapid intracellular release drugs. First, both adenine-terminated poly(ε-caprolactone) (PCL-A) uracil-terminated poly(ethylene glycol) (PEG-U) synthesized. The amphiphilic block copolymers (PCL-A:U-PEG) formed based on bonding interactions between PCL-A PEG-U. self-assembled from PCL-A:U-PEG sufficiently...
Honeycomb-structured microporous films were self-assembled from a new type of multiarm copolymer, hyperbranched poly(3-ethyl-3-oxetanemethanol)-star-polystyrene (HBPO-star-PS). The precursor consisting an HBPO core and number PS arms was synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization. film prepared the evaporation chloroform solution in humid atmosphere (the so-called breath figure method). Compared to our former work, hexagonally packed pores not...
Titanium dioxide nanoparticles (nano-TiO2) have been widely applied in daily life and subsequent problem on the potential health risk are raised. Studies toxicity of nano-TiO2 shown that they could lead to toxic effects human environment. However, mechanisms still unclear. We investigated change amino acid levels L929 cells after exposure using gas chromatography with time-of-flight mass spectrometry (GC/TOFMS)-based metabolomics approach. Spectral profiles were subjected multivariate...
A double-hydrophilic multiarm hyperbranched polymer with a poly(amidoamine) (HPAMAM) core and many poly(ethylene glycol) monomethyl ether (MPEG) arms connected by pH-sensitive acylhydrazone bonds (HPAMAM-g-MPEG) was successfully prepared. Benefiting from the cationic dendritic PEGylation shell, used as nanoreactor for CdS quantum dots (CdS QDs) synthesis in aqueous solution. The obtained HPAMAM-g-MPEG CdS/HPAMAM-g-MPEG nanocomposites were carefully characterized 1H NMR, 13C Fourier transform...
ABSTRACT As titanium dioxide (TiO 2 ) nanoparticles are widely used commercially, their potential biosafety and metabolic mechanism needs to be fully explained. In this study, the cytotoxicity of homogeneous weakly aggregated (< 100 nm) TiO was investigated by analyzing changes in metabolite profiles both mouse fibroblast (L929) cells corresponding culture media using gas chromatograph with a time‐of‐flight mass spectrometry (GC/TOFMS)‐based metabolomic strategy. With multivariate...
Dynamic diblock polymer PS-r-PEG formed via reversible acylhydrazone connection can be used to construct a pH-responsive self-assembled encapsulation system with high stability and sustained-release property, which shows potential in drug delivery.
The exploration of safe and efficient polycationic gene vectors from natural small molecules such as kanamycin was proposed. Cationic hyperbranched glycoconjugated polymer synthesized by the Michael-addition polymerization N,N′-methylenebisacrylamide, resultant product well characterized FTIR, 1H NMR, 13C SEC-MALLS ζ-potential analyses. nitrogen content (7.3%) this kanamycin-based much lower than that (32.6%) polyethylenimine (PEI) control. Moreover, could be degraded in acidic conditions....
Abstract A novel type of drug carrier capable controlled release is proposed. It consists an acid‐sensitive doubly hydrophilic multiarm hyperbranched copolymer with a polyamidoamine core and many linear poly(ethylene glycol) arms. Using pH‐sensitive acylhydrazone linkages, the polymer forms unimolecular micelles that can encapsulate hydrophobic drugs. Due to their amphiphilicity, drug‐loaded self‐assemble into multimolecular show acid‐triggered intracellular delivery magnified image
There is a great demand for dental implants with the ability to accelerate periimplant bone regeneration. Modification of surface micro‐ and nanotopographies has been revealed affect cell metabolism. In this study, we utilized dielectric barrier discharge (DBD) technology modify commercially pure titanium (Ti‐tr) surfaces then investigated cytocompability DBD‐modified Ti when compared machined (Ti‐m) polished (Ti‐p) surfaces. These three kinds plates exhibited different energies topographies...
The optical constants of highly (100)-oriented LaNiO3 thin films on Pt(111)-Ti–SiO2–Si substrate derived by metalorganic deposition have been obtained using spectroscopic ellipsometry techniques in the wide wavelength range from ultraviolet to far infrared. In fitting dielectric functions LaNiO3, two harmonic oscillators are observed, one is believed come valence–conduction interband transition and other attributed a donor band conduction. Simultaneously frequency plasmon also obtained,...
Abstract A new two‐phase route was developed to prepare monodisperse cadmium sulfide (CdS) quantum dots (QDs) with a narrow size distribution. In system, chloroform and water were used as separate solvents for palmitoyl chloride functionalized hyperbranched polyamidoamine (HPAMAM‐PC) acetate/sodium sulfide, respectively. The amphiphilic HPAMAM‐PC, hydrophilic dendritic core hydrophobic arms, formed stable unimolecular micelles in encapsulate aqueous Cd 2+ ions. After the reaction S 2− ions...
Understanding the cellular mechanisms underlying early allograft rejection is crucial for development of effective immunosuppressant strategies. This study aims to investigate composition graft-infiltrating cells during stage at a single-cell level and identify potential therapeutic targets.A heterotopic heart transplant model was established using enhanced green fluorescent protein (eGFP)-expressing mice as recipients allogeneic or syngeneic grafts. At 3 days post-transplant, eGFP-positive...
[V2(HCyclal)2] is prepared by controlled oxidation of vanadium nanoparticles at 50 °C in toluene. The V(0) are synthesized THF reduction VCl3 with lithium naphthalenide. They exhibit very small particle sizes 1.2 ± 0.2 nm and a high reactivity (e.g. air or water). By reaction the azacrown ether H4Cyclal, obtained deep green crystals yield. title compound exhibits V(III) dimer (V⋯V: 304.1(1) pm) two deprotonated [HCyclal]3- ligands as anions. well sole coordination crown ligand nitrogen...