A5046269230- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Photoacoustic and Ultrasonic Imaging
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Mycobacterium research and diagnosis
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Enterobacteriaceae and Cronobacter Research
- Immune cells in cancer
- Anesthesia and Pain Management
- Olfactory and Sensory Function Studies
- Reproductive System and Pregnancy
- RNA Research and Splicing
- Organ Transplantation Techniques and Outcomes
- Fungal Infections and Studies
- Ferroptosis and cancer prognosis
- Single-cell and spatial transcriptomics
- Advanced Fluorescence Microscopy Techniques
- Radiomics and Machine Learning in Medical Imaging
- vaccines and immunoinformatics approaches
Northwestern Polytechnical University
2019-2025
Taixing People's Hospital
2022-2025
Weatherford College
2019
Luoyang Normal University
2018
Abstract Photodynamic therapy (PDT) holds significant promise for antibacterial treatment, with its potential markedly amplified when using Type I photosensitizers (PSs). However, developing PSs remains a challenge due to lack of reliable design strategy. Herein, PS nanocluster is developed via self‐assembly zwitterionic small molecule (C3TH) superior PDT in vivo. Mechanism studies demonstrate that unique cross‐arranged C3TH within not only shortens intermolecular distance but also inhibits...
Developing organic photothermal materials (OPMs) with high performance for phototheranostic mainly focus on the manipulation of intramolecular nonradiative (intraNR) decay, which often requires quite complicated and time-consuming molecular engineering. In addition to intraNR intermolecular (interNR) decay is equally important more convenient in governing performance. However, controlling interNR remains challenging due limited understanding their origin dynamics. Here, systemic...
The dynamics of excited‐state charge transfer (CT) in second near‐infrared (NIR‐II) fluorophore proceeds with conformational change that govern fluorescence. Unveiling the relationship between CT and excited state is great fundamental significance optimizing NIR‐II fluorescence but remains less explored. This study unveils pivotal role large promoting evolution emissive into nonemissive (CA‐BBT). Spectroscopic computational results reveal rotation/twisting leads to a pronounced increase...
Liver cancer is a leading cause of cancer-related deaths globally. Tumor response rate liver patients towards systemic chemotherapy low and chemoresistance can easily develop. Identifying novel molecules that repress drug resistance metastasis will facilitate the development new therapeutic strategies. The aim this study to determine roles NUAK1 miR-204 in reveal their relationship. We found was increased tumor primary cancer. Knockdown significantly inhibited cell growth migration....
Background: Integrating comprehensive information on hepatocellular carcinoma (HCC) is essential to improve its early detection. We aimed develop a model with multi-modal features (MMF) using artificial intelligence (AI) approaches enhance the performance of HCC Materials and methods: A total 1,092 participants were enrolled from 16 centers. These allocated into training, internal validation, external validation cohorts. Peripheral blood specimens collected prospectively subjected mass...
Early detection of a tumour remains an unmet medical need, and approaches with high sensitivity specificity are urgently required. Mass cytometry time-of-flight (CyTOF) is powerful technique to profile immune cells could be applied detection. We attempted establish diagnostic models for hepatocellular carcinoma (HCC) pancreatic ductal adenocarcinoma (PDAC).We performed CyTOF analysis 2348 participants from 15 centres, including 1131 hepatic diseases, 584 diseases 633 healthy volunteers....
In this study, we investigated the effect of inhaled mixtures volatile organic compounds (VOCs) and carbon monoxide (CO) on neuroethology. Fifty 6-week-old male Kunming mice were exposed in five similar static chambers; zero (control) four different doses VOC CO (G1–G4) for 10 consecutive days 2 h/day. The concentrations as follows: formaldehyde, benzene, toluene, xylene, 0.10 + 0.11 0.20 10.00 mg/m 3 , 0.22 0.40 20.00 1.00 1.10 2.00 100.00 5.00 5.50 500.00 respectively, which corresponded...
Photocytotoxicity represents a significant limitation in the application of dye-assisted fluorescence imaging (FI), often resulting undesirable cellular damage or even cell death, thereby restricting their practical utility. The prevalence Rhodamine B (RhB) FI underscores importance elucidating its photocytotoxicity effects to minimize photodamage. This study identifies primary cause stems from generation cytotoxic singlet oxygen RhB, utilizing femtosecond transient absorption spectroscopy...
Pancreatic adenocarcinoma is often diagnosed at an advanced stage when adjacent vascular invasion present. Accurate evaluation of presence can help guide therapy. The aim this study was to construct a nomogram for preoperative prediction peripancreatic vein in patients with pancreatic head cancer. Data carcinoma pancreas and suspected (n = 247) who underwent resection venous reconstruction between January 2012 2017 four academic institutions were retrospectively analyzed. Univariate...
BACKGROUNDSurgical site infections (SSI) remain a major cause of morbidity after hepatectomy for hepatocellular carcinoma (HCC). AIMTo identify the risk factors associated with SSI, and develop nomogram to predict SSI among patients undergoing hepatectomy.
Background: Situs inversus (SI) is a rare congenital anomaly characterized by the transposition of thoracic and abdominal viscera. Laparoscopic pancreaticoduodenectomy (LPD) increasingly used in patients with periampullar pancreatic carcinomas. For SI, LPD can be more complicated because reversed anatomy possible other associated anomalies that have not been expected before surgery. Case Presentation: A female patient SI totalis presented inappetence, vomiting, weight loss for 2 months....
The excited-state dynamics of indocyanine green (ICG) fundamentally determine its photophysical properties for phototheranostic. However, are predictable to be susceptible toward intracellular viscosity due almost freely rotating structure, making the precise phototheranostic very challenging. Therefore, correlating with ICG is great importance and urgency prospects. This study presents systemic investigations on viscosity-dependent Femtosecond transient absorption (fs-TA) experiments...
Abstract To generate a nomogram to predict posthepatectomy liver failure (PHLF), we attempted elucidate salient risk factors in patients with hepatocellular carcinoma (HCC). We performed retrospective review of 665 HCC who received hepatectomy 2 academic institutions China. Independent for PHLF were identified from putative demographic, intrinsic, biochemical, surgery-related, and volumetric data. A predictive was formulated based on relevant factors, compared this existing models. clinical...
Cryptococcal species often cause lung infections and are the main of fungal meningitis. Claudin-4 appears to be a major structural component that maintains tight alveolar barrier prevents fluid electrolyte leakage into space. We aimed determine whether S7-tetrahydrocurcumin (THC) could clearance C. deneoformans regulate claudin-4 expression during infection. investigated effect THC on infection its possible mechanism in vivo. Transmission electron microscopy was used observe ultrastructure...
The purpose of this study was to investigate the effect a simple laparoscopic common bile duct exploration (LCBDE) simulator and corresponding practicing program on application performing LCBDE in low volume center.A retrospective review performed by analyzing data from electronic medical record for 4118 patients with choledocholithiasis Changxing County Hospital (Huzhou, Zhejiang, China) between January 2013 December 2018. From 2016, we have developed LCBDE-specific our hospital. percentage...
Photothermal Therapy In article number 2301739, Wenbo Hu and co-workers present an excimer-mediated intermolecular nonradiative (interNR) decay channel to produce a giant photothermal effect for high-efficient in vivo phototheranostics. A deep understanding of the interNR provides novel guidelines developing more advanced organic materials.
<p indent="0mm">Photodynamic therapy is a clinically approved novel therapeutic technique that employs photosensitizer in the presence of suitable light to produce cytotoxic reactive oxygen species (ROS). According ROS types, photosensitizers are divided into Type I (free radical) and II (singlet oxygen). Compared with II, has low dependence on oxygen, presenting excellent prospects overcoming limitations hypoxic cancer treatment. However, there limited scope photosensitizers. Moreover, few...