A5073844760- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Gastrointestinal disorders and treatments
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Immunotherapy and Immune Responses
- Cancer Diagnosis and Treatment
- AI in cancer detection
Second Military Medical University
2016-2025
Changhai Hospital
2016-2025
Shaanxi Provincial People's Hospital
2019-2025
Shanghai Electric (China)
2024
Guangxi Subtropical Crops Research Institute
2017-2024
Gansu Provincial Hospital
2019-2024
First Affiliated Hospital of Henan University
2024
Chongqing University of Science and Technology
2024
Northeastern University
2024
Tsinghua University
2002-2023
Pancreatic ductal adenocarcinoma (PDAC), the most deadly solid malignancy, is typically detected late and at an inoperable stage. Early or incidental detection associated with prolonged survival, but screening asymptomatic individuals for PDAC using a single test remains unfeasible due to low prevalence potential harms of false positives. Non-contrast computed tomography (CT), routinely performed clinical indications, offers large-scale screening, however, identification non-contrast CT has...
Despite the uniform mortality in pancreatic adenocarcinoma (PDAC), clinical disease heterogeneity exists with limited genomic differences. A highly aggressive tumor subtype termed 'basal-like' was identified to show worse outcomes and higher inflammatory responses. Here, we focus on microbial effect PDAC progression present a comprehensive analysis of microbiome different subtypes resectable tumors using metagenomic sequencing. We found distinctive communities basal-like an increasing...
The incidence rate of lung adenocarcinoma (LUAD), the predominant histological subtype cancer, is elevated in Asians, particularly female nonsmokers. mutation patterns LUAD Asians might be distinct from those whites.We profiled 271 resected tumors (mainly stage I) to characterize genomic landscape with a focus on nonsmokers.Mutations EGFR, KRAS, erb-b2 receptor tyrosine kinase 2 gene (ERBB2), and BRAF; fusions involving anaplastic lymphoma (ALK), ROS1, ret proto-oncogene (RET); Met...
Chromatin accessibility plays an essential role in controlling cellular identity and the therapeutic response of human cancers. However, chromatin landscape gene regulatory network pancreatic cancer are largely uncharacterized. Here, we integrate profiles 84 organoid lines with whole-genome sequencing data, transcriptomic data results drug sensitivity analysis 283 epigenetic-related chemicals 5 chemotherapeutic drugs. We identify distinct transcription factors that distinguish molecular...
Metabolic reprogramming is known as an emerging mechanism of chemotherapy resistance, but the metabolic signatures pancreatic ductal adenocarcinomas (PDACs) remain unclear. Here, we characterize metabolomic profile PDAC organoids and classify them into glucomet-PDAC (high glucose metabolism levels) lipomet-PDAC lipid levels). Glucomet-PDACs are more resistant to than lipomet-PDACs, patients with have a worse prognosis. Integrated analyses reveal that GLUT1/aldolase B...
Atherosclerosis occurs preferentially at vascular curvature and branch sites where the vessel walls are exposed to fluctuating shear stress have high endothelial permeability. Endothelial permeability is modulated by intercellular adhesion molecules such as VE-cadherin. This study was designed elucidate effects of different flow patterns on localization expression VE-cadherin in cells (ECs) both vivo vitro. staining EC borders much stronger descending thoracic aorta abdominal aorta,...
Abstract Mesenchymal stem cells (MSC) represent a new tool for delivery of therapeutic agents to cancer sites because their strong tropism toward tumors. IL15 has demonstrated potent antitumor activity in various animal models as well clinical trials. However, its short half-life, effective effects usually require high dose, which often results undesired side effects; thus, strategies overcoming this disadvantage are needed. In study, human MSCs were isolated from umbilical cord blood...
Abstract Background About 25–37% of resectable pancreatic ductal adenocarcinoma (PDAC) had a great chance early recurrence after radical resection, which is mainly due to preoperative micrometastasis. We herein demonstrated the profiles ctDNA in PDAC and use identify patients with potential Methods A total 113 44 PDACs were enrolled discovery validation cohorts, separately. panel containing 50 genes was used screen by an NGS-based assessment high specificity. Results In cohort, overall...
Objective The objective of this study was to explore the exact relationship between arterial radiomics score (rad-score) and lymph node (LN) metastasis in pancreatic ductal adenocarcinoma (PDAC). Methods A total 225 patients with pathologically confirmed PDAC who underwent multislice computed tomography within 1 month resection from December 2016 August 2017 were retrospectively studied. For each patient, 1029 features phase extracted, which reduced using least absolute shrinkage selection...
CT-Based Radiomics Score for Distinguishing Between Grade 1 and 2 Nonfunctioning Pancreatic Neuroendocrine TumorsYun Bian1, Hui Jiang2, Chao Ma1, Li Wang2, Jianming Zheng2, Gang Jin3 Jianping Lu1Audio Available | Share
N6-methyladenosine (m6A) has been reported as an important mechanism of post-transcriptional regulation. Programmed death ligand 1 (PD-L1) is a primary immune inhibitory molecule expressed on tumor cells that promotes evasion. In addition, seven in absentia homolog 2 (Siah2), RING E3 ubiquitin ligase, involved tumorigenesis and cancer progression. However, the role m6A-METTL14-Siah2-PD-L1 axis immunotherapy remains to be elucidated. this study, we showed METTL14, component m6A...
The aim of the study was to determine occurrence and risk factors diabetes mellitus (DM) in Chinese patients with chronic pancreatitis (CP), particular emphasis on those endoscopic or surgical therapy for CP.Four hundred forty-five contacted CP our hospital between January 1, 1997, July 31, 2007, were followed up. Risk DM determined a multivariate analysis after exclusion 58 patients.The cumulative rate 51.5% (SD, 8%) at 20 years onset 27.8% 6%) 10 endotherapy surgery, without significant...
Background: Pancreatic ductal adenocarcinoma (PDAC) is an almost universally lethal disease. Deregulation or dysfunction of miRNAs contribute to cancer development. The role miR-940 in PDAC remains unclear. Methods: level tissues and cell lines was measured by qRT-PCR. MiR-940 over-expressed mimics transfection reduced antisense oligonucleotides (ASO) transfection. Cell proliferation analyzed MTT assay apoptosis evaluated FACS analysis. Targeted genes were predicted a bioinformatics...
Apoptosis-stimulating of p53 protein 2 (ASPP2) is one the ASPP family members and it has been reported to be associated with human cancer. However, role in pancreatic cancer still not clear.We analyzed expression level ASPP2 tissue samples RT-qPCR, Western Blotting assay immunohistochemistry staining. We studied biological function its mechanism gene overexpression silencing technologies. determined sensitivity cells differential gemcitabine whether autophagy inhibition affected resistance,...
Hypoxia contributes significantly to the development of chemoresistance many malignancies including esophageal cancer (EC). Accumulating studies have indicated that long non-coding RNAs play important roles in chemotherapy resistance. Here, we identified a novel lncRNA-EMS/miR-758-3p/WTAP axis was involved hypoxia-mediated cisplatin human EC. induced expressions lncRNA EMS and WTAP, reduced expression miR-758-3p EC cell line ECA-109. In addition, WTAP were required for hypoxia-induced drug...