A5100664082- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Pancreatitis Pathology and Treatment
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Neuroendocrine Tumor Research Advances
- Advanced Causal Inference Techniques
- Covalent Organic Framework Applications
- Epigenetics and DNA Methylation
- Atrial Fibrillation Management and Outcomes
- Genetic factors in colorectal cancer
- Advanced Nanomaterials in Catalysis
- Glioma Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Gallbladder and Bile Duct Disorders
- Statistical Methods in Clinical Trials
- Congenital Heart Disease Studies
- Cardiac and Coronary Surgery Techniques
- Chromatin Remodeling and Cancer
- Cancer-related gene regulation
- Nanocluster Synthesis and Applications
- Adrenal and Paraganglionic Tumors
Inserm
2020-2025
Université Paris Cité
2020-2025
Sorbonne Université
2020-2025
Sorbonne Paris Cité
2025
Pitié-Salpêtrière Hospital
2022-2024
Ruijin Hospital
2014-2024
Shanghai Jiao Tong University
2014-2024
Shandong University
2022-2024
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
Neuropathy is a feature more frequently observed in pancreatic ductal adenocarcinoma (PDAC) than other tumors. Schwann cells, the most prevalent cell type peripheral nerves, migrate toward tumor cells and associate with poor prognosis PDAC. To unveil effects of on neuro-stroma niche, here we perform single-cell RNA-sequencing microarray-based spatial transcriptome analysis PDAC tissues. Results suggest that may drive cancer-associated fibroblasts (CAFs) to malignant subtypes: basal-like...
Robot-assisted pancreaticoduodenectomy (RPD) has been reported to be safe and feasible. As a new technique, RPD learning curve similar that of other types minimally invasive pancreatic surgery such as laparoscopic pancreaticoduodenectomy. To our knowledge, no reports exist on the outcomes open (OPD) after curve.To analyze evaluate actual advantages RPD.Between May 2010 December 2018, 450 patients underwent in Shanghai Ruijin Hospital affiliated with Jiaotong University Shanghai, China,...
We aimed to describe our experience and the learning curve of 450 cases robot-assisted pancreaticoduodenectomy (RPD) optimize surgical process so that findings can be useful for surgeons starting perform RPD.Robotic systems were first introduced 20 years ago. Pancreaticoduodenectomy (PD) is a challenging surgery because its technical difficulty. RPD may overcome some these difficulties.The medical records patients who underwent between May 2010 December 2018 at Shanghai Ruijin Hospital...
Nanocatalytic therapy is an emerging technology that uses synthetic nanoscale enzyme mimics for biomedical treatment. However, in the field of neuroscience, achieving neurological protection while simultaneously killing tumor cells a technical challenge. Herein, we synthesized biomimic and translational cerium vanadate (CeVO4) nanozyme glioblastoma (GBM) repair brain damage after GBM ionizing radiation (IR). This system exhibited pH dependence: it showed potent Superoxide dismutase (SOD)...
Abstract Background: Two first-line treatments are commonly used for metastatic pancreatic cancer: FOLFIRINOX and gemcitabine plus nab-paclitaxel. However, a direct head-to-head comparison in randomized clinical trial has not yet been conducted. Collecting enough data this requires collaboration among multiple partner institutions. Herein we use privacy enhancing technology called federated learning combined with novel algorithmic methodology: FedECA. This method aims to facilitate by...
Background Glioblastoma (GBM) is a fatal brain tumor with no effective treatment. The specific GBM immune microenvironment (TIME) may contribute to resistance immunotherapy, therapy great potential. Thus, an in-depth understanding of the characteristics tumor-infiltrating cells essential for exploring biomarkers in pathogenesis and immunotherapy. Methods We estimated relative abundances 25 cell types 796 samples using single sample gene set enrichment analysis (ssGSEA). Unsupervised...
Background: Glioblastoma multiforme (GBM) is an aggressive brain tumour for which current traditional treatment approaches have been unsuccessful, owing to the high genetic heterogeneity and immunosuppressive microenvironment. Methods: Single-cell spatial transcriptomic data revealed niche-specific enrichment of mesenchymal-like (MES-like) GBM cells monocyte-derived macrophages (MDMs); Gain- loss-of-function assays HDAC7 was confirmed both in vitro vivo assays. Mechanistically, mass...
International normalized ratio (INR) self-testing can improve the management of anticoagulation therapy with warfarin for patients following mechanical heart valve replacement. Several reviews and studies have demonstrated self-management as an option to patient's outcome considerably after We sought analyze security, economy discuss prospect in replacement China, evaluate accuracy stability CoaguChek XS portable INR-testing device.This was a prospective self-controlled clinical study...
Epithelial-to-mesenchymal transition (EMT) is tightly associated with the invasion and metastasis of pancreatic cancer rapid progression poor prognosis. Notably, gene alternative splicing (AS) event plays a critical role in regulating cancer. Therefore, this study aims to identify EMT-related AS cancer.The sets, transcriptomes, matched clinical data were obtained from MSigDB, The Cancer Genome Atlas (TCGA), International Consortium (ICGC), Gene Expression Omnibus (GEO) databases. Key events...
Pancreatic cancer is a highly aggressive featured by early metastasis and multiple chemoresistance. Surgical resection remains the only way for radical cure of pancreatic cancer. The aim this study was to assess safety, feasibility oncological effect Heidelberg TRIANGLE operation in total pancreatectomy (TP) borderline resectable (BRPC).Patients with BRPC eligible TP were selected underwent operation. Sharp dissection applied separate tumor involved artery. Then we completely dissected soft...
Transthoracic device closure (TTDC) and surgical repair with right infra-axillary thoracotomy (SRRIAT) are two main alternative minimally invasive approaches for restrictive perimembranous ventricular septal defect (VSD); however, few studies have compared them each other in terms of effectiveness cost.Patients VSD undergoing TTDC or SRRIAT from January 2012 to July 2013 were reviewed a comparative investigation between the procedures.Success procedures was achieved 30 (30/33, 91%) 96...
Rationale: Accumulating evidence illustrated that the reprogramming of super-enhancers (SEs) landscape could promote acquisition metastatic features in pancreatic cancer (PC).Given anatomy-based TNM staging is limited by heterogeneous clinical outcomes treatment, it great significance to tailor individual stratification and develop alternative therapeutic strategies for PC patients based on SEs.Methods: In our study, ChIP-Seq analysis H3K27ac was performed primary tumors (PTs) hepatic...
Metastasis is a key component of cancer progression and strongly associated with poor prognosis. Perineural invasion thought to be related pain, tumor recurrence, other conditions. However, the exact molecular mechanism unclear. This study was conducted identify components signaling pathways involved in perineural pancreatic alterations phenotype after interaction between dorsal root ganglion (DRG) cells. The results indicated that p38 mitogen-activated protein kinase pathway activated...
The aim of the present study was to report initial clinical experience adopting da Vinci Surgical System (Intuitive Surgical, Inc., Sunnyvale, CA, USA) perform a retroperitoneal tumor resection. patient 56-year-old female who presented with five-year history hypertension. Abdominal dynamic computed tomography (CT) and positron emission tomography-CT scans revealed mass measuring ~6 cm in diameter that located anterior abdominal aorta, between aorta inferior vena cava (at level third lumbar...