A5103256867- Telomeres, Telomerase, and Senescence
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Nutritional Studies and Diet
- Occupational and environmental lung diseases
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Pleural and Pulmonary Diseases
- Cancer Genomics and Diagnostics
- Effects and risks of endocrine disrupting chemicals
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Fatty Acid Research and Health
- Extracellular vesicles in disease
- Cancer Risks and Factors
- Helicobacter pylori-related gastroenterology studies
- Sirtuins and Resveratrol in Medicine
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
Rutgers, The State University of New Jersey
2010-2025
University of Shanghai for Science and Technology
2025
Nanjing Medical University
2004-2024
Jiangsu Shengze Hospital
2022-2024
Peking Union Medical College Hospital
2021-2024
Southwest Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Affiliated Zhongshan Hospital of Dalian University
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Jiangxi Provincial People's Hospital
2024
Objective Fibroblast activation protein (FAP) plays a vital role in tumor invasion and metastasis. Previous studies have reported its prognostic value different tumors. However, the results of these reports remain controversial. In this study, meta-analysis was performed to clarify issue. Methods A search PubMed, Embase CNKI databases conducted analyze relevant articles. The outcomes included relations between FAP expression histological differentiation, invasion, lymph node metastasis,...
Introduction: The triglyceride glucose index (TyG) is associated with cardiovascular diseases; however, its association stroke remains unclear. This study aimed to elucidate this relationship by examining two extensive cohort studies using two-sample Mendelian randomization (MR). Methods: Using data from the 1999–2018 National Health and Nutrition Examination Survey (NHANES) Medical Information Mart for Intensive Care (MIMIC)-IV, correlation between TyG (continuous quartile) was examined...
Abstract Telomeres consist of a tandem repeats the sequence TTAGGG at ends chromosomes and play key role in maintenance chromosomal stability. Previous studies indicated that short telomeres are associated with increased risk for human bladder, head neck, lung, renal cell cancer. We investigated association between white blood telomere length breast cancer among 268 family sets (287 cases 350 sister controls). Telomere was assessed by quantitative PCR. The mean shorter (mean, 0.70; range,...
Telomeres play a critical role in maintaining the integrity and stability of genome, are susceptible to oxidative damage after telomere shortening length. In present study, we explored white blood cell DNA length on breast cancer risk, examined whether urinary 15-F(2)-isoprostanes (15-F(2t)-IsoP) 8-oxo-7,8-dihydrodeoxyguanosine (8-oxodG) or dietary antioxidant intake modified relationship between risk. A population-based case-control study-the Long Island Breast Cancer Study Project-was...
Sirt6 is an NAD+-dependent deacetylase that involved in the control of energy metabolism. However, tissue-specific function adipose tissue remains unknown. In this study, we showed fat-specific knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed adipocyte hypertrophy rather than hyperplasia. The FKO likely resulted from compromised lipolytic activity as outcome decreased expression triglyceride lipase (ATGL), a key enzyme. suppression ATGL accounted for by...
Irisin, a hormone proteolytically processed from fibronectin type III domain-containing protein 5 (FNDC5), has been reported to induce the browning of sc adipocytes by increasing level uncoupling 1. In this study, we showed that activation nuclear receptor constitutive androstane induced FNDC5 mRNA expression in liver and increased circulating irisin mice. FNDC5/irisin is direct transcriptional target receptor. Hepatic-released functioned as paracrine/autocrine factor inhibited lipogenesis...
Regular exercise can protect the heart against external stimuli, but mechanism is not well understood. We determined role of adenosine monophosphate-activated protein kinase (AMPK) in regulating swimming exercise-mediated cardiac protection β-adrenergic receptor overstimulation with isoproterenol (ISO) mice. Ten-week-old AMPKα2+/+ and AMPKα2-knockout (AMPKα2-/-) littermates were subjected to 4 weeks training (50 min daily, 6 days a week) or housed under sedentary conditions. The mice...
Abstract Background About 25–37% of resectable pancreatic ductal adenocarcinoma (PDAC) had a great chance early recurrence after radical resection, which is mainly due to preoperative micrometastasis. We herein demonstrated the profiles ctDNA in PDAC and use identify patients with potential Methods A total 113 44 PDACs were enrolled discovery validation cohorts, separately. panel containing 50 genes was used screen by an NGS-based assessment high specificity. Results In cohort, overall...
Most studies of environmental risk factors and breast cancer are conducted using average cohorts.We examined the association between polycyclic aromatic hydrocarbon (PAH)-albumin adducts in bloods from baseline a prospective nested case-control study (New York site BCFR, 80 cases 156 controls). We estimated 10-year absolute by model that uses pedigree information (BOADICEA) evaluated whether increased PAH differed risk.Women with detectable levels had twofold (odds ratio (OR)=2.04; 95%...
Objective: To assess the disparities in effectiveness and identify outcome predictors treatment of a targeted-first radiotherapy-first regimen with driver gene-positive lung cancer brain metastases.Materials Methods: This retrospective study analyzed patients metastases who received first-targeted first-radiotherapy regimens, respectively, SIB-WBRT (whole tissue 40 Gy/20 fractions, tumor boosted to 56-60 fractions) local irradiation (prescription dose range 20-60 Gy/2-25 most commonly...
Currently, efficient regimens to reverse atherosclerotic plaques are not available in the clinic. Herein, we present sonodynamic therapy (SDT) as a novel methodology rapidly inhibit progression of plaques.
The sorting of domestic waste is the most effective way to alleviate problem mass garbage accumulation around villages rural China. Farmers are creators as well direct beneficiaries management. However, few studies have been conducted on psychological determinants farmers’ intentions sort waste. This paper applies planned behavior theory (TPB) and normative activation (NAM), analyze residents in Guanzhong, Based micro-data 327 households structural equation models factors influencing were...
The increase in blood nicotine after smoking a single cigarette is boost. We hypothesized that smokers with schizophrenia (SCZ) have greater boost than controls without this disorder.Twenty-one subjects (11 SCZ and 10 controls, CON) had repeated venous sampling before, during, 12-hr abstinence to measure concentrations. Blood samples were drawn at baseline (before smoking) 1, 2, 4, 6, 8, 10, 20, 30, 60, 90, 120 min the first puff. Groups similar characteristics, including gender level of...
Reactive oxygen species (ROS) elevation and mitochondrial membrane potential (MMP) loss have been proven recently to be involved in sonodynamic therapy (SDT)-induced macrophage apoptosis necrosis. This study aims develop an experimental system monitor intracellular ROS MMP real-time during ultrasonic irradiation order achieve optimal effect SDT. Cultured THP-1 derived macrophages were incubated with 5-aminolevulinic acid (ALA), then sonicated at different intensities. Intracellular detected...
Background and Purpose Paracetamol (acetaminophen) is the most widely used over‐the‐counter analgesic overdosing with paracetamol leading cause of hospital admission for acute liver failure. 5‐Lipoxygenase (5‐LO) catalyses arachidonic acid to form LTs, which lead inflammation oxidative stress. In this study, we examined whether deletion or pharmacological inhibition 5‐LO could protect mice against paracetamol‐induced hepatic toxicity. Experimental Approach Both genetic in C57BL/6J were study...
Abstract Purpose This study aimed to develop and validate a method for characterizing the spatial resolution of clinical chest computed tomography (CT) sequence images. Methods An algorithm based on CT images was developed in Matlab (2021b). The validated using from custom‐made automatic tube current modulation (ATCM) phantom clinically reconstructed A region interest (ROI) automatically established at edges image subject calculate edge spread function (ESF). ESF curves consecutive within...
Importance Pancreas cancer is the seventh leading cause of death and colorectal second worldwide, with increasing incidence for both, particularly in younger age cohorts. Objective To report updated trends pancreas adenocarcinomas US, specific intent examining annual percentage changes (APCs) groups. Design, Setting, Participants This retrospective cohort study used data from Surveillance, Epidemiology, End Results database to examine 2000 2021. Individuals pancreatic adenocarcinoma were...
Abstract Purpose: Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahydrofolate dehydrogenase (MTHFD) plays an important role in and homocysteine metabolisms, polymorphisms of MTHFD may result disturbance the folate-mediated pathway. aim this study is to test hypothesis genetic variants plasma levels are associated with risk cancer modulated by genotypes reductase (MTHFR). Experimental Design: We genotyped G1958A T401C C677T MTHFR...
To explore the etiologic role of genetic variants in telomere pathway genes and breast cancer risk.A population-based case-control study, Long Island Breast Cancer Study Project, was conducted, 1,067 cases 1,110 controls were included present study. Fifty-two nine telomere-related genotyped.Seven single nucleotide polymorphisms (SNP) showed significant differences at level P < 0.05. The top three statistically SNPs under a dominant model TERT-07 (rs2736109), TERT-54 (rs3816659), POT1-03...
BACKGROUND In laboratory experiments, ω‐3 polyunsaturated fatty acids (PUFAs) have been found to reduce inflammatory eicosanoids resulting from ω‐6 PUFA metabolism via competitive inhibition, and the ω‐3‐induced cytotoxic environment increases apoptosis reduces cell growth in breast cancer cells. To authors' knowledge, epidemiologic investigations regarding whether dietary intake benefits survival after are limited inconsistent. METHODS The authors used resources a population‐based follow‐up...
MicroRNAs (miRNAs or miR-) have been linked to factors associated with aggressive prostate cancer such as biochemical recurrence and metastasis. We investigated whether circulating miRNAs in plasma could be used diagnostic biomarkers for more at biopsy.Men, aged 40 years above, newly diagnosed were categorized into two risk groups, low-grade (Gleason score, 6 7 [3 + 4] serum prostate-specific antigen [PSA], <20 ng/mL) high-grade ≥7 (4 3) PSA, ≥20 cancers. The limma R package was compare the...
Background: Many chronic metabolic diseases, such as obesity and type 2 diabetes (T2DM), are closely related to a low-grade inflammatory state in tissues. The high prevalence of non-alcoholic fatty liver disease (NAFLD) patients with T2DM is the role inflammation disease. In this study, we investigated liraglutide improving lipid metabolism disorders preventing their progression NAFLD by modulating signaling pathways, thereby providing new treatment options for NAFLD. Methods: We designed...