A5101430151- Lipid metabolism and biosynthesis
- Adipose Tissue and Metabolism
- Advanced Memory and Neural Computing
- Nanopore and Nanochannel Transport Studies
- Enzyme Catalysis and Immobilization
- Research in Cotton Cultivation
- Sulfur Compounds in Biology
- Pancreatic function and diabetes
- Fuel Cells and Related Materials
- Nuclear Structure and Function
- Metabolism, Diabetes, and Cancer
- Body Contouring and Surgery
- Endoplasmic Reticulum Stress and Disease
- Receptor Mechanisms and Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neural Engineering
- Plant biochemistry and biosynthesis
- Photoreceptor and optogenetics research
- Liver Disease Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Mast cells and histamine
- Antioxidant Activity and Oxidative Stress
- Myofascial pain diagnosis and treatment
- Neural dynamics and brain function
Southern University of Science and Technology
2023-2025
East China Jiaotong University
2025
Peking University
2015-2024
Institute of Modern Physics
2019-2020
Chinese Academy of Sciences
2019-2020
University of Chinese Academy of Sciences
2019-2020
Lanzhou University
2019-2020
Southwest Jiaotong University
2019
State Key Laboratory of Natural and Biomimetic Drugs
2019
Harbin Engineering University
2018
Akey step in lipolytic activation of adipocytes is the translocation hormone-sensitive lipase (HSL) from cytosol to surface lipid storage droplet. Adipocytes perilipin-null animals have an elevated basal rate lipolysis compared with wild-type mice, but fail respond maximally stimuli. This defect downstream β-adrenergic receptor–adenylyl cyclase complex. Now, we show that HSL basally associated droplet surfaces at a low level perilipin nulls, stimulated droplets absent derived embryonic...
Hypercortisolemia and glucocorticoid treatment cause elevated level of circulating free fatty acids (FFAs). The basis this phenomenon has long been linked to the effect glucocorticoids permitting enhancing adipose lipolysis response various hormones. In study, we demonstrate that directly stimulate in rat primary adipocytes a dose- time-responsive manner; lipolytic action was attenuated by with antagonist RU486. Dexamethasone down-regulates mRNA protein levels cyclic-nucleotide...
Biological voltage-gated ion channels, which behave as life's transistors, regulate transport precisely and selectively through atomic-scale selectivity filters to sustain important life activities. By this inspiration, voltage-adaptable ionic transistors that use ions signal carriers may provide an alternative information processing unit beyond solid-state electronic devices. This review provides a comprehensive overview of the first generation biomimetic including their operating...
The voltage-gated ion channels, also known as ionic transistors, play substantial roles in biological systems and ion-ion selective separation. However, implementing the ultrafast switchable capabilities polarity switching of transistors remains a challenge. Here, we report nanofluidic transistor based on carbon nanotubes, which exhibits an on/off ratio 10
Adipose differentiation-related protein (ADRP) is localized to lipid droplets in most mammalian cells. ADRP, proposed regulate fatty acid mobilization and droplet formation, linked accumulation foam cells of human atherosclerotic lesions. In this report, we show that ADRP accumulates Chinese hamster ovary fibroblastic cultured the presence oleic but destabilized when sources are removed from culture serum. The latter effect was blocked by proteasome inhibitor MG132, whereas inhibitors other...
Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is an autosomal recessive disorder characterized by almost complete loss of adipose tissue, insulin resistance and fatty liver. Here, we create the first murine model BSCL2 targeted disruption seipin, causative gene for BSCL2. Compared with their wild-type littermates, seipin−/− mice are viable normal weight but display significantly reduced tissue mass, hepatic steatosis, glucose intolerance hyperinsulinemia. The levels leptin...
Recently, periadventitial adipose tissue (PAT) was found to secrete bioactive factors playing an important role in the regulation of vascular tension. Hydrogen sulfide (H(2)S), a novel cardiovascular gasotransmitter, relaxes vessels through K(ATP) channel calcium-dependent and endothelial-independent manner.We first identified endogenous H(2)S-generated key enzyme cystathionase (CSE) expressed adipocytes PAT H(2)S released from rats.The CSE inhibitors DL-propargylglycine and/or...
Bacterial endotoxin/lipopolysaccharide elicits inflammatory responses and also elevates circulating levels of free fatty acids (FFAs) impairs insulin sensitivity. Serum FFA elevation in acute endotoxemia has long been thought to be due endotoxin dysregulating lipid disposal counterregulatory hormones cytokines. Here, we investigated the direct lipolysis effect rodents isolated primary adipocytes. Endotoxin increases vivo adipose tissues, level, induces resistance rats, directly stimulates...
Aims: Hydrogen sulfide (H2S) has a protective role in the pathogenesis of atherosclerosis by multiple pathways. Sirtuin-1 (SIRT1) is histone deacetylase, as an essential mediated longevity gene, and anti-atherogenic effect regulating acetylation some functional proteins. Whether SIRT1 involved protecting H2S its mechanism remains unclear. Results: In ApoE-knockout mice, treatment with donor (NaHS or GYY4137) reduced atherosclerotic plaque area, macrophage infiltration, aortic inflammation,...
Type 2 diabetes is a chronic inflammatory metabolic disease, the key point being insulin resistance. Endoplasmic reticulum (ER) stress plays critical role in pathogenesis of type diabetes. Previously, we found that hyperhomocysteinemia (HHcy) induced resistance adipose tissue. Here, hypothesized HHcy induces ER stress, which turn promotes In present study, direct effect Hcy on was investigated by use primary rat adipocytes vitro and mice with vivo. The mechanism G protein-coupled receptor...
Sirt6 is an NAD+-dependent deacetylase that involved in the control of energy metabolism. However, tissue-specific function adipose tissue remains unknown. In this study, we showed fat-specific knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed adipocyte hypertrophy rather than hyperplasia. The FKO likely resulted from compromised lipolytic activity as outcome decreased expression triglyceride lipase (ATGL), a key enzyme. suppression ATGL accounted for by...
FAM3A belongs to a novel cytokine-like gene family, and its physiological role remains largely unknown. In our study, we found marked reduction of expression in the livers db/db high-fat diet (HFD)-induced diabetic mice. Hepatic overexpression markedly attenuated hyperglycemia, insulin resistance, fatty liver with increased Akt (pAkt) signaling repressed gluconeogenesis lipogenesis those contrast, small interfering RNA (siRNA)-mediated knockdown hepatic resulted hyperglycemia reduced pAkt...
Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is the most severe form of human lipodystrophy, characterized by an almost complete loss adipose tissue and insulin resistance. BSCL2 caused loss-of-function mutations in BSCL2/SEIPIN gene, which upregulated during adipogenesis abundantly expressed tissue. The physiological function SEIPIN mature adipocytes, however, remains to be elucidated. Here, we generated adipose-specific Seipin knockout (ASKO) mice, exhibit adipocyte...
Hydrogen sulfide (H2 S) plays a protective role in NAFLD. However, whether cystathionine γ lyase (CSE), dominant H2 S generating enzyme hepatocytes, has the pathogenesis of NAFLD is currently unclear.We showed that CSE protein expression dramatically downregulated, especially fibrotic areas, livers from patients with In high-fat diet (HFD)-induced mice or an oleic acid-induced hepatocyte model, CSE/H2 pathway also downregulated. To illustrate regulatory for NAFLD, we generated...
Voltage-gated ion channels prevalent in neurons play important roles generating action potential and information transmission by responding to transmembrane potential. Fabricating bio-inspired ionic transistors with ions as charge carriers will be crucial for realizing neuro-inspired devices brain-liking computing. Here, we reported a two-dimensional nanofluidic transistor based on MXene membrane sub-1 nm interlayer channels. By applying gating voltage the nanofluidic, generated active...
The effective and precise processing of visual information by the human eye primarily relies on diverse contrasting functions achieved through synaptic regulation ion transport in retina. Developing a bio-inspired retina that uses ions as carriers can more accurately replicate retina's natural signal capabilities, enabling high-performance machine vision. Herein, an ion-confined strategy is proposed to construct developing artificial synapses with inhibitory excitatory functions. By...
Homocysteine (Hcy) is epidemiologically related to insulin resistance, which has been speculated be a low-grade systemic inflammatory condition. Resistin acts as critical mediator of resistance associated with conditions. We aimed determine whether Hcy can induce by directly regulating the expression and secretion resistin from adipose tissue.The effect on was investigated using primary rat adipocytes mice hyperhomocysteinemia (HHcy).Hcy impaired glucose transport and, particularly,...
Objective To assess the global changes in and characteristics of transcriptome long noncoding RNAs (LncRNAs) heart tissue, whole blood plasma during failure (HF) association with expression paired coding genes. Methods Here we used microarray assay to examine LncRNAs deregulated heart, blood, HF mice. We confirmed by quantitative PCR. Results revealed a number that were HF, which suggests potential role HF. Strikingly, patterns LncRNA differed between other tissue was associated length all...
Abstract Testicular Leydig cells contain abundant cytoplasmic lipid droplets (LDs) as a cholesteryl-ester store for releasing cholesterols the precursor substrate testosterone biosynthesis. Here, we identified protein composition of testicular LDs purified from adult mice by using mass spectrometry and immunodetection. Among 337 proteins identified, 144 were previously detected in LD proteomes; 44 confirmed microscopy. contained multiple Rab GTPases, chaperones involved glucuronidation,...
Hydrogen sulfide (H2S) has antihypertension and anti-inflammatory effects, its endogenous-generation key enzyme cystathionine γ lyase (CSE) is expressed in CD4+ T cells. However, the role of T-cell endogenous CSE/H2S development hypertension unclear.Peripheral blood lymphocytes were isolated from hypertensive patients or spontaneously rats, then H2S production expression generation enzymes, β synthase CSE, measured to determine major system changes hypertension. Mice with CSE-specific...
The next-generation brain-like intelligence based on neuromorphic architectures emphasizes learning the ionic language of brain, aiming for efficient computation and seamless human-computer interaction. Ionic devices, with ions serving as information carriers, provide possibilities to achieve this goal. Soft biocompatible conductive hydrogels are an ideal substrate constructing but it remains a challenge modulate ion transport behavior in mimic neuroelectric signals. Here, we describe...