A5100326594- Epigenetics and DNA Methylation
- Oral microbiology and periodontitis research
- Adipose Tissue and Metabolism
- Cancer-related gene regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Drug Transport and Resistance Mechanisms
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV Research and Treatment
- Inflammasome and immune disorders
- Oral Health Pathology and Treatment
- Alzheimer's disease research and treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Exercise and Physiological Responses
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Salivary Gland Disorders and Functions
- Hippo pathway signaling and YAP/TAZ
- Microencapsulation and Drying Processes
- Immune Response and Inflammation
- Semantic Web and Ontologies
Xi'an Jiaotong University
2022-2025
Microbiology Institute of Shaanxi
2025
Southwest Medical University
2018-2025
Washington University in St. Louis
2025
Duke University
2024
Université de Montréal
2013-2024
Wuxi No.2 People's Hospital
2024
Jiangnan University
2024
Nantong University
2024
Peking University
2016-2024
Abstract Electric signal accelerates full‐thickness wound healing in the clinic, which is usually generated by a large power generation system and requires delicate control authorized personnel. Here, self‐powered flexible biocompatible thermoelectric device with exceptionally high efficiency developed. It generates 10 mV voltage at temperature gradient of K, outperforming all reported devices. Accordingly, it can directly efficiently convert omnipresent heat skin to electricity microvolt...
Sirt6 is an NAD+-dependent deacetylase that involved in the control of energy metabolism. However, tissue-specific function adipose tissue remains unknown. In this study, we showed fat-specific knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed adipocyte hypertrophy rather than hyperplasia. The FKO likely resulted from compromised lipolytic activity as outcome decreased expression triglyceride lipase (ATGL), a key enzyme. suppression ATGL accounted for by...
Postovulatory aging is known to compromise the oocyte quality as well subsequent embryo development in many different animal models, and becomes one of most intractable issues that limit outcome human assisted reproductive technology (ART). However, strategies prevent deterioration aged oocytes relevant mechanisms are still underexplored. Here, we find supplementation CoQ10, a natural antioxidant present follicular fluids, able restore postovulatory aging-induced fragmentation decline...
The growing demand for mental health support has highlighted the importance of conversational agents as human supporters worldwide and in China. These could increase availability reduce relative costs support. provided can be divided into two main types: cognitive emotional. Existing work on this topic mainly focuses constructing that adopt Cognitive Behavioral Therapy (CBT) principles. Such operate based pre-defined templates exercises to provide However, research emotional using such is...
Abstract Cigarette smoking at diagnosis or during therapy correlates with poor outcome in patients lung and esophageal cancers, yet the underlying mechanisms remain unknown. In this study, we observed that exposure of cancer cells to cigarette smoke condensate (CSC) led upregulation xenobiotic pump ABCG2, which is expressed stem confers treatment resistance carcinomas. Furthermore, CSC increased side population containing cells. Upregulation ABCG2 coincided occupancy aryl hydrocarbon...
Irisin, a hormone proteolytically processed from fibronectin type III domain-containing protein 5 (FNDC5), has been reported to induce the browning of sc adipocytes by increasing level uncoupling 1. In this study, we showed that activation nuclear receptor constitutive androstane induced FNDC5 mRNA expression in liver and increased circulating irisin mice. FNDC5/irisin is direct transcriptional target receptor. Hepatic-released functioned as paracrine/autocrine factor inhibited lipogenesis...
Gut-associated lymphoid tissues are enriched in CCR6+ Th17-polarized CD4+ T cells that contribute to HIV-1 persistence during antiretroviral therapy (ART). This raises the need for Th17-targeted immunotherapies. In an effort identify mechanisms governing permissiveness/persistence gut-homing Th17 cells, we analyzed transcriptome of versus CCR6– exposed inducer retinoic acid (RA) and performed functional validations colon biopsies HIV-infected individuals receiving ART (HIV+ART). Although...
BACKGROUND Fibrosis is the common pathological feature in most kinds of chronic kidney disease (CKD). TGF-β/Smads signaling master pathway regulating fibrosis pathogenesis, which Smad3 acts as integrator various pro-fibrosis signals. In this study, we analyzed role SIS3, a specific inhibitor Smad3, mouse unilateral ureteral obstruction (UUO) kidneys. MATERIAL AND METHODS UUO mice were intraperitoneally injected with 0.2 mg/kg/day or 2 SIS3 control saline for 7 days, followed by analysis...
Qianliexin capsule (QLX) is a standardized traditional Chinese herbal preparation that has long been used to treat chronic non-bacterial prostatitis (CNP) and benign prostatic hyperplasia (BPH). This study investigated the anti-inflammatory activity of QLX in improving lower urinary tract symptoms (LUTS) associated with CNP BPH. Rat models BPH were induced by oestradiol or testosterone (hormonal imbalance) chemical inflammation (carrageenan). significantly relieved LUTS rat model reducing...
Objective: This study investigates the effects of CangFu Daotan Decoction (CDD) on m6A methylation and Wnt/β-catenin pathway in rats with polycystic ovary syndrome (PCOS).Methods: The PCOS rat model was established by letrozole gavage. were fed high-fat chow, their body weight blood glucose recorded. expressions follicle-stimulating hormone(FSH), luteinizing hormone(LH), testosterone(T) quantified ELISA. Chemical components CDD analyzed using UPLC-Q/TOF-MS. Based network pharmacology...
Considering the high recrudescence and long-lasting unhealed large-sized wound that affect aesthetics cause dysfunction after resection of maxillofacial malignant skin tumors, a groundbreaking strategy is urgently needed. Photothermal therapy (PTT), which has become complementary treatment however, powerless in tissue defect regeneration. Therefore, novel multifunctional sodium nitroprusside Fe
Atherosclerosis is an inflammatory process characterized by proliferation and dedifferentiation of vascular smooth muscle cells (VSMC). Ca v 1.2 calcium channels may have a role in atherosclerosis because they are essential for 2+ -signal transduction VSMC. The pore-forming 1.2α1 subunit the channel subject to alternative splicing. Here, we investigated whether splice variants affected atherosclerosis. VSMC were isolated laser-capture microdissection from frozen sections adjacent regions...
Abstract Background We previously demonstrated that primary Th1Th17 cells are highly permissive to HIV-1, whereas Th1 relatively resistant. Molecular mechanisms underlying these differences remain unknown. Results Exposure replication competent and single-round VSV-G pseudotyped HIV strains provide evidence superior in vs. was regulated by located at entry post-entry levels. Genome-wide transcriptional profiling identified transcripts upregulated (n = 264) downregulated 235) (p-value <...
To investigate the association between clinical periodontal parameters of periodontitis, serum lipid metabolism markers and adipokines' levels in patients with obesity periodontitis.A total 112 admitted to Hospital Xi'an Jiaotong University were included this study. They divided into normal body weight group (18.5 < mass index, BMI 25, n = 36), overweight (25 ≤ 30, 38), (BMI ≥ 38) accordingly. The diagnosis periodontitis was based on newest international classification periodontitis....
Cardiovascular disease (CVD) remains an important comorbidity in people living with HIV-1 (PLWH) receiving antiretroviral therapy (ART). Our previous studies performed the Canadian HIV/Aging Cohort Study (CHACS) (>40 years-old; Framingham Risk Score (FRS) > 5%) revealed a 2–3-fold increase non-calcified coronary artery atherosclerosis (CAA) plaque burden, measured by computed tomography angiography scan (CTAScan) as total (TPV) and low attenuated volume (LAPV), ART-treated PLWH (HIV+)...
Targeted therapy has a pivotal role for the treatment of liver cancer. The aim this current study was to examine effects decursin on growth HepG2 cells and underlying mechanisms. Our present showed that with significantly inhibited by suppressing cell proliferation, cycle arresting, promoting apoptosis in dose‐ time‐dependent manner. Most significantly, administration dramatically impeded vivo tumor nude mice. Mechanically, it is noteworthy provoked degradation YAP upregulating expression...