A5101966892- Adipose Tissue and Metabolism
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Lung Cancer Treatments and Mutations
- Graphene and Nanomaterials Applications
- Pancreatic function and diabetes
- HER2/EGFR in Cancer Research
- Computational Drug Discovery Methods
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Inflammatory Bowel Disease
- Metabolism, Diabetes, and Cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Metabolomics and Mass Spectrometry Studies
- Suicide and Self-Harm Studies
- Vascular anomalies and interventions
- Cardiac tumors and thrombi
- Body Image and Dysmorphia Studies
- Regulation of Appetite and Obesity
- Reproductive System and Pregnancy
- Pregnancy-related medical research
- Natural product bioactivities and synthesis
- Parathyroid Disorders and Treatments
Zhengzhou University
2018-2025
Sichuan University
2006-2024
China Medical University
2024
Fourth Affiliated Hospital of China Medical University
2024
Sun Yat-sen University
2023
Chengdu Second People's Hospital
2023
West China Hospital of Sichuan University
2006-2022
State Key Laboratory of Biotherapy
2019-2021
Second Xiangya Hospital of Central South University
2021
Central South University
2021
The diabetes medication canagliflozin (Cana) is a sodium glucose cotransporter 2 (SGLT2) inhibitor acting by increasing urinary excretion and thus reducing hyperglycaemia. Cana treatment also reduces body weight. However, it remains unclear whether could directly work on adipose tissue. In the present study, pharmacological effects of associated mechanism were investigated in adipocytes mice. Stromal-vascular fractions (SVFs) isolated from subcutaneous tissue differentiated into mature...
Sirt6 is an NAD+-dependent deacetylase that involved in the control of energy metabolism. However, tissue-specific function adipose tissue remains unknown. In this study, we showed fat-specific knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed adipocyte hypertrophy rather than hyperplasia. The FKO likely resulted from compromised lipolytic activity as outcome decreased expression triglyceride lipase (ATGL), a key enzyme. suppression ATGL accounted for by...
Irisin, a hormone proteolytically processed from fibronectin type III domain-containing protein 5 (FNDC5), has been reported to induce the browning of sc adipocytes by increasing level uncoupling 1. In this study, we showed that activation nuclear receptor constitutive androstane induced FNDC5 mRNA expression in liver and increased circulating irisin mice. FNDC5/irisin is direct transcriptional target receptor. Hepatic-released functioned as paracrine/autocrine factor inhibited lipogenesis...
Activation of hepatic stellate cells (HSCs) contributes to the development liver fibrosis. Because a relatively small population HSCs in and lack specific membrane targeting proteins, HSC-targeted therapy remains major clinical challenge. Here we first showed that hallmark activated HSC (aHSC) is their increased expression integrin αvβ3. Thus established sterically stable liposomes contain cyclic peptides (cRGDyK) with high affinity αvβ3 achieve aHSC-specific delivery. Our results...
Activating beige adipocytes in white adipose tissue (WAT) to increase energy expenditure is a promising strategy combat obesity. We identified that mesencephalic astrocyte-derived neurotrophic factor (Manf) feeding-induced hepatokine. Liver-specific Manf overexpression protected mice against high-fat diet-induced obesity and promoted browning of inguinal subcutaneous WAT (iWAT). liver was also associated with decreased inflammation improved insulin sensitivity hepatic steatosis....
Sexual dysfunction (SD) in patients who suffer from inflammatory bowel disease (IBD) has not attracted widespread attention, and thus research studies are scarce.
<title>Abstract</title> Background Colorectal cancer (CRC) ranks as the third most commonly diagnosed and second leading cause of cancer-related deaths worldwide. Approximately 95% its histologic subtypes are colon adenocarcinoma (COAD). To date, numerous studies have investigated potential impact circulating microelements on COAD. However, causal association between mirculating COAD remains unclear. Therefore, our study implemented two-sample Mendelian randomization (MR) analyses to explore...
Inhibition of the sodium-glucose cotransporter 2 (SGLT2) induces hypoglycaemia by increasing urinary glucose excretion and use fat. However, underlying mechanism is poorly understood. This study was aimed to determine effects canagliflozin, a selective SGLT2 inhibitor, on diet-induced obesity mechanism(s).Adult C57BL/6J male mice were fed with standard chow diet or high-fat supplemented vehicle canagliflozin. Whole body energy expenditure monitored metabolic cages, noradrenaline levels...
This study investigated the biological functions and prognostic significance of centromere protein L (CNTRL) in glioma. mRNA expression data clinical information were obtained from TCGA, CGGA, an independent cohort 207 glioma patients. CNTRL levels quantified using qRT-PCR. Functional analyses, including Gene Ontology KEGG pathway enrichment, conducted to elucidate roles CNTRL. Kaplan-Meier survival curves Cox regression analyses applied evaluate its association with overall survival, a...
The aim of this study was to investigate whether the nuclear receptor farnesoid X (FXR) could regulate FNDC5/Irisin expression and role Irisin in hyperlipidemia atherosclerosis ApoE-/- mice.We treated primary human hepatocytes, HepG2 cells, Rhesus macaques with FXR agonist (CDCA, GW4064, ivermectin). FNDC5 highly induced by CDCA GW4064 circulating level increased macaques. Luciferase reporter CHIP assays were used determine promoter activity. Irisin-ApoE-/- mice metabolic function...
Human umbilical cord mesenchymal stem cells (hUCMSCs) are recognized as candidate progenitor for bone regeneration. However, the mechanism of hUCMSC osteogenesis remains unclear. In this study, we revealed that mitogen-activated protein kinases (MAPKs) signaling is involved in osteogenic differentiation vitro . Particularly, activation c-Jun N-terminal (JNK) and p38 pathways maintained a consistent level hUCMSCs through entire 21-day period. At same time, extracellular signal-regulated (ERK)...
Background and Purpose: Activation of hepatic stellate cells (HSC) is a central driver liver fibrosis. 5-lipoxygenase (5-LO) the key enzyme that catalyzes arachidonic acid into leukotrienes. In this study, we examined role 5-LO in HSC activation Main Methods: Culture medium was collected from quiescent activated for target metabolomics analysis. Exogenous leukotrienes were added to culture explore their effect activating HSC. Genetic ablation mice used study its fibrosis induced by CCl 4...
Sirtuin 6 (Sirt6) is an NAD+-dependent deacetylase that regulates central metabolic functions such as glucose homeostasis, fat metabolism, and cell apoptosis. However, the tissue-specific function of Sirt6 in liver regeneration remains unknown. Here, we show liver-specific knockout (Sirt6LKO) impaired reconstitution after 2/3 partial hepatectomy, which was attributed to alteration cycle progression. LKO delayed hepatocyte transition into S phase during regeneration, shown by analysis...
OPINION article Front. Pharmacol., 10 December 2019Sec. Translational Pharmacology Volume - 2019 | https://doi.org/10.3389/fphar.2019.01475
Background: With the approval of gefitinib, erlotinib, afatinib, and osimertinib for clinical use, targeting Epidermal Growth Factor Receptor (EGFR) has been intensively pursued. Similar to most therapies, challenges related treatment resistance against these drugs have emerged over time, so new EGFR Tyrosine Kinase Inhibitors (TKIs) need be developed. This study aimed investigate potential use a series thiophene-bearing quinazoline derivatives as inhibitors. We designed synthesized nine...
Abstract Background Treating lateral compression type 1 (LC1) pelvic ring injuries in older patients is controversial. This study evaluated surgical treatments combined with ERAS for treating LC1 fractures the elderly. Methods In this retrospective study, who underwent surgery INFIX (supra-acetabular spinal pedicle screws, and a subcutaneous connecting rod; experimental group) or superior pubic ramus cannulated screw (the control fixation of fracture from January 2019 to 2022 were reviewed....