A5101592705- Spine and Intervertebral Disc Pathology
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
- Spinal Fractures and Fixation Techniques
- MicroRNA in disease regulation
- RNA modifications and cancer
- Peroxisome Proliferator-Activated Receptors
- Spinal Cord Injury Research
- Cervical and Thoracic Myelopathy
- Circular RNAs in diseases
- Adipose Tissue and Metabolism
- Cholesterol and Lipid Metabolism
- Pelvic and Acetabular Injuries
- Medical Imaging and Analysis
- Bone health and treatments
- Gastric Cancer Management and Outcomes
- Bariatric Surgery and Outcomes
- Polysaccharides and Plant Cell Walls
- Gut microbiota and health
- Soybean genetics and cultivation
- Venous Thromboembolism Diagnosis and Management
- Cancer-related gene regulation
- Liver Disease Diagnosis and Treatment
- Polysaccharides Composition and Applications
- Bone Metabolism and Diseases
General Hospital of Guangzhou Military Command
2019-2025
Beijing Institute of Graphic Communication
2025
Southern Medical University
2015-2024
Nanfang Hospital
2015-2024
Agro-Environmental Protection Institute
2022-2024
Ministry of Agriculture and Rural Affairs
2022-2024
Anhui Academy of Agricultural Sciences
2022-2024
International Collaboration On Repair Discoveries
2024
Shandong University
2024
Xinxiang Medical University
2024
Breast cancer is a major cause of mortality among women. It important to identify modifiable risk factors for this disease.To examine body mass index (BMI) at the age 18 years and midlife adult weight change in relation breast incidence mortality.Cohort study.A cohort 95256 US female nurses aged 30 55 who were followed up 16 years.Incident fatal cancer.During 1203498 person-years, 2517 incident cancers (60% postmenopausal) documented. Higher current BMI was associated with lower before...
Obesity increases the risk for hypertension, but effects of modest long-term weight changes have not been precisely quantified.To investigate body mass index (BMI) and change in relation to hypertension.Cohort study.General community.Cohort 82,473 U.S. female nurses 30 55 years age followed every 2 since 1976. The follow-up rate was 95%.Primary factors examined were 1) BMI at 18 midlife 2) medium-term changes. outcome incident cases hypertension.By 1992, 16,395 hypertension had diagnosed....
This study examined prospectively the associations of waist circumference and waist:hip ratio with risk breast cancer. A total 47,382 US registered nurses who reported their hip circumferences in 1986 were followed up through May 1994 for identification incident cases During 333,097 person-years follow-up, 1,037 invasive cancers diagnosed. In proportional hazards analyses, was nonsignificantly related to premenopausal cancer but significantly associated postmenopausal after adjustment...
The ketone metabolite β-hydroxybutyrate (βOHB), is reported to be neuroprotective after spinal cord injury (SCI) in rats, but the underlying mechanism remains unknown. present study aims investigate effects of βOHB on suppression oxidative stress and inhibition class I histone deacetylases (HDACs) vivo vitro models. Rats were fed with ketogenic diet (KD) or standard (SD) for 3 weeks. A C5 hemi-contusion was applied these animals 14th day experiment, samples harvested 1st, 3rd 7th days SCI,...
Perfluoroalkyl acids (PFAAs) are a group of emerging persistent organic pollutants (POPs), which have been ubiquitously detected in the environmental media. However, national scale investigations on their occurrence and distribution drinking water still insufficient. In this study, we 17 priority PFAAs from 79 cities 31 provincial-level administrative regions throughout China, investigated distribution. Additionally, also analyzed influencing factors profiles, such as existence industrial...
Drought stress is the key factor limiting soybean yield potential. Soybean seed formation involves a coordinated “subtending leaf-podshell-seed” process, but little known about assimilation and transport of photoassimilates in subtending leaves, podshells seeds or their relationships with under drought stress. To address these research gaps, two-year experiments two cultivars, Wandou 37 (drought tolerant) Zhonghuang 13 sensitive), were conducted three soil water content (SWC) conditions 2020...
The authors examined the relation of constitutional factors and sun exposure to risk basal cell carcinoma skin (BCC) in a prospective cohort 44,591 predominantly Caucasian US male health professionals, 40–75 years age free cancer at enrollment 1986. During 8 follow-up, 3,273 cases self-reported BCC were documented. following variables each associated with an elevated BCC: having red hair; green, hazel, or blue eyes; tendency sunburn; north European ancestry. lifetime number blistering...
This study investigated three aspects of general nutritional status (dietary intake, biochemical markers, and anthropometric measurements) in relation to subsequent hip fracture risk by using prospective data from the First National Health Nutrition Examination Survey (NHANES I) epidemiologic follow-up studies. A cohort 2,513 white women 45 years over who participated NHANES I survey 1971–1975 were subsequently followed studies 1982–1984, 1986, 1987, respectively. Multiple variables measured...
Cysteine (C)-X-C motif chemokine receptor 4 (CXCR4), the primary for stromal cell-derived factor-1 (SDF-1), is involved in bone morphogenic protein 2 (BMP2)-induced osteogenic differentiation of mesenchymal progenitors. To target vivo function CXCR4 and explore underlying mechanisms, we conditionally inactivated osteoprecursors by crossing osterix (Osx)-Cre mice with floxed (CXCR4(fl/fl)) to generate knock-outs deletion driven Osx promoter (Osx::CXCR4(fl/fl)). The Cre-mediated excision...
The ENCORE registry aimed at comparing the long-term safety of Crohn's disease [CD] treatment with infliximab [Remicade®] and conventional therapies in real-world clinical practice. 5-year, prospective, observational followed patients CD nine European countries, who received infliximab, therapies, or switched to from therapy. Adverse events [AEs] pre-specified categories serious AEs were recorded least every 6 months 5-year observation period. Frequency was evaluated, multivariable analyses...
Recent studies have shown that miR-494-3p is oncogene and has a central role in many solid tumors; however, the of progression prognosis hepatocellular carcinoma (HCC) remains unknown. In this study, it was found up-regulated HCC tissues. The high level tumors correlated with aggressive clinicopathological characteristics predicted poor patients. Functional study demonstrated significantly promoted cell metastasis vitro vivo. Since phosphoinositide 3-kinase/protein kinase-B (PI3K/AKT)...
Abstract Recent work with gut microbiota after bariatric surgery is limited, and the results have not been in agreement. Given role of regulating host metabolism, we explored effect Roux‐en‐Y gastric bypass (RYGB) sleeve gastrectomy (SG) on modifications regard to potential influence food intake and/or weight loss examined their links metabolism. Zucker diabetic fatty rats were divided into following groups: RYGB; sham‐operated pair‐fed as fed ad libitum ; SG. The metabolic effects profile...
N6-methyladenosine (m6A) has been reported as an important mechanism of post-transcriptional regulation. Programmed death ligand 1 (PD-L1) is a primary immune inhibitory molecule expressed on tumor cells that promotes evasion. In addition, seven in absentia homolog 2 (Siah2), RING E3 ubiquitin ligase, involved tumorigenesis and cancer progression. However, the role m6A-METTL14-Siah2-PD-L1 axis immunotherapy remains to be elucidated. this study, we showed METTL14, component m6A...
The nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome has been reported to be involved in the pathological process of osteoarthritis (OA) inflammation. Here, we investigated ketogenic diet (KD), which previously demonstrated inhibit NLRP3 activation, elucidate its protective mechanism against OA rats.