A5088058471- Connexins and lens biology
- Plant Stress Responses and Tolerance
- Intraocular Surgery and Lenses
- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Sperm and Testicular Function
- Pharmacological Effects of Natural Compounds
- Plant responses to water stress
- Retinal Diseases and Treatments
- Adipose Tissue and Metabolism
- Mechanical Circulatory Support Devices
- Neurological Disease Mechanisms and Treatments
- Flowering Plant Growth and Cultivation
- Testicular diseases and treatments
- Aldose Reductase and Taurine
- Advanced Glycation End Products research
- Cancer, Hypoxia, and Metabolism
- Heart Rate Variability and Autonomic Control
- Autophagy in Disease and Therapy
- Glaucoma and retinal disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Traumatic Ocular and Foreign Body Injuries
- Sulfur Compounds in Biology
- Healthcare and Venom Research
- Traditional Chinese Medicine Analysis
Nanjing Forestry University
2007-2025
Shanghai Jiao Tong University
2025
Shanghai Sixth People's Hospital
2025
People's Liberation Army 401 Hospital
2025
Chinese People's Liberation Army
2025
Beijing Anzhen Hospital
2024
Affiliated Hospital of Southwest Medical University
2024
Xijing Hospital
2009-2023
Air Force Medical University
2009-2023
Henan Institute of Science and Technology
2008-2023
Exercise and dietary intervention are currently available strategies to treat nonalcoholic fatty liver disease (NAFLD), while the underlying mechanism remains controversial. Emerging evidence shows that lipophagy is involved in inhibition of lipid droplets accumulation. However, it still unclear if exercise improve NAFLD through regulating lipophagy, how skeletal muscle can modulate metabolism liver. Moreover, associated with aging, little known about effect accumulation on aging process....
In this study, we investigated the effects of different lead (Pb) concentrations (0, 200, 600, 1000, 1400 mg kg-1 soil) on growth, ion enrichment in tissues, photosynthetic and physiological characteristics, cellular structures privet seedlings. We observed that with increase Pb, growth seedlings was restricted, level Pb increased roots, stem, leaves seedlings; however, most ions were concentrated roots. Moreover, a decreasing trend for chlorophyll a, b, total chlorophyll, net photosynthesis...
Mercury chloride can cause severe liver injury, which involves multiple mechanisms. Ferroptosis plays an important role in regulating the development and progression of pathology. Oleanolic acid (OA), a triterpenoid compound widely exists fruits, has protective properties. In this study, we investigated ferroptosis mercury chloride-induced injury intervention effect OA, clarified potential mechanism. We found that oxidative stress tissues cells, leading to lipid peroxidation iron overload,...
Diabetic cataract is a common complication of diabetes. The epithelial-mesenchymal transition (EMT) lens epithelial cells (LECs) key event in the development diabetic cataracts. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been reported to be highly expressed different tissues patients. This study aimed at investigating function and mechanism MALAT1 regulation EMT human LECs under high glucose conditions. MALAT1, α-smooth muscle actin (α-SMA), fibronectin (FN), nuclear...
The hexavalent form of chromium, Cr (VI), has been associated with various diseases in humans. In this study, we examined the mechanisms underlying effect (VI) on glucose and lipid metabolism vivo vitro. We found that induced abnormal liver function, increased fasting blood (FBG), as well insulin intolerance mice. Furthermore, decreased glucose-6-phosphate (G6P) level transporter-2 (GLUT2) expression, levels triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), reduced high-density...
Prolactin (PRL) plays a key role in the regulation of reproductive functions. However, its impact on outcomes infertility women undergoing assisted technology remains unclear. This study aimed to examine relationship between PRL levels and frozen embryo transfer (FET) cycles under hormone replacement therapy (HRT). A total 1212 FET HRT were included from single center Shanghai March 2013 June 2023. measured day before progesterone-induced endometrial transformation participants stratified...
To investigate the impacts of various foliar fertilization levels on carbon, nitrogen, phosphorus, and potassium content in Chinese fir cuttings, along with their ecological stoichiometry ratios, we selected pruned dwarf clones exhibiting different seed-setting abilities as our subjects. These were categorized into high-yield (group A), middle-yield B), low-yield C) categories for nutrient assessment. Employing nine treatments diverse fertilizers hormones, addition to a water control (CK),...
We show that alpha 6 integrin function was required for normal lens cell differentiation by using an antisense construct to suppress expression. To elucidate the mechanism which this functions in regulation of process, we determined molecular composition signaling complexes at distinct stages vivo. Because both and insulin-like growth factor-1 (IGF-1) have been implicated differentiation, examined possibility they formed a complex embryonic lens. Coprecipitation analysis revealed...
<i>Background:</i> Vascular endothelial growth factor (VEGF) is upregulated by hypoxia and a major stimulatory for choroidal neovascularization. The upregulation of VEGF expression in response to occurs through hypoxia-inducible 1 (HIF-1), which transcription that regulates genes involved the hypoxia. HIF-1α inducible subunit HIF-1. <i>Aims:</i> To further define HIF-1 function angiogenesis explore novel approaches modulate neovascularization age-related macular...
Aims: High-fat diet (HFD)-induced insulin resistance (IR) impairs skeletal muscle mitochondrial biogenesis and functions, adversely affecting human health lifespan. Vitamin K2 (VK2) has a beneficial role in improving sensitivity glucose metabolism. However, the underlying molecular mechanisms of VK2 on have not been well established. We investigated VK2's modulation function to protect against IR mice cell models. Results: supplementation could effectively ameliorate development by both...
In Brief Background Early identification of high-risk patients provides clinicians with greater decision-making time and better informs strategies to cope disease. The predictive values age shock index (age SI) age-modified MSI) in ST-segment elevation myocardial infarction (STEMI) undergoing emergency percutaneous coronary intervention (PCI) have rarely been reported, especially compared those for SI, MSI, the Global Registry Acute Coronary Events (GRACE) risk score. Patients methods Nine...
Abstract A number of randomized controlled trials and real‐world studies have demonstrated the effectiveness safety secukinumab in treatment moderate to severe psoriasis, whereas data on a large cohort Chinese patients long‐term practice are limited. This was single‐centre, uncontrolled, single‐arm, prospective, observational study that included 254 psoriatic treated with between September 2019 December 2022. Demographic clinical characteristics patients, response adverse events were...
Respiration influences the subdiaphragmatic venous return in total cavopulmonary connection (TCPC) of Fontan circulation whereby both inferior vena cava (IVC) and hepatic vein flows can experience retrograde motion. Controlling could improve patient outcomes. Using a patient-specific model within mock circulatory system with respiration, we inserted valve into IVC to examine its effects on local hemodynamics while varying volumes by changing vascular impedances. A bovine valved conduit...