A5109332576- Retinal Diseases and Treatments
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Glaucoma and retinal disorders
- Connexins and lens biology
- RNA Interference and Gene Delivery
- Advanced Glycation End Products research
- Cardiovascular Function and Risk Factors
- Autophagy in Disease and Therapy
- Heart Failure Treatment and Management
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- interferon and immune responses
- Cancer-related molecular mechanisms research
- IgG4-Related and Inflammatory Diseases
- Epigenetics and DNA Methylation
- Systemic Lupus Erythematosus Research
- Retinal Development and Disorders
- Phagocytosis and Immune Regulation
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Elasticity and Material Modeling
- Sepsis Diagnosis and Treatment
- Lipid metabolism and disorders
- Retinopathy of Prematurity Studies
Xijing Hospital
2019-2024
Soochow University
2024
Air Force Medical University
2020-2024
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Tianjin University
2024
Seattle University
2024
Nanjing University
2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
University of Washington
2024
As artificial intelligence (AI) theory becomes more sophisticated and its utilization spreads across daily life, education, professional settings, the adoption of AI for medical diagnostic service purposes stands as a logical progression in evolution technologies. This document outlines novel approach to detecting cancer cell targets using deep learning-based system, marking critical step towards integrating into diagnostics. The process entails localization types within images cells. By...
Diabetic cataract is a common complication of diabetes. The epithelial-mesenchymal transition (EMT) lens epithelial cells (LECs) key event in the development diabetic cataracts. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been reported to be highly expressed different tissues patients. This study aimed at investigating function and mechanism MALAT1 regulation EMT human LECs under high glucose conditions. MALAT1, α-smooth muscle actin (α-SMA), fibronectin (FN), nuclear...
Inflammatory pseudotumor (IPT) of the liver is a rare, benign lesion that characterized by proliferating fibrous tissue infiltrated inflammatory cells. The exact etiology IPT remains unclear. Although association with systemic disorders has been established, specific link Crohn’s disease rare. We report two cases associated disease. Both patients were elderly males who presented abdominal pain and jaundice. At time presentation, both had active was undiagnosed. Computed tomography...
Proliferative vitreoretinopathy (PVR) is a disease leading to the formation of contractile preretinal membranes (PRMs) and one causes blindness. Connective tissue growth factor (CTGF) has been identified as possible key determinant progressive fibrosis excessive scarring. Therefore, present study investigated role mechanism action CTGF in PVR. Immunohistochemical staining was performed detect expression CTGF, fibronectin collagen type III PRMs from patients with The effects mechanisms...
Abstract Background Cataracts are the leading cause of blindness and a common ocular complication diabetes. The epithelial-mesenchymal transition (EMT) lens epithelial cells (LECs) altered autophagic activity occur during development diabetic cataracts. disturbed interaction autophagy with EMT in LECs stimulated by high glucose levels may participate cataract formation. Methods A rat model induced streptozotocin (STZ) human (HLE-B3) concentration were employed study. These models treated...
The aim of this study was to investigate the modified Ross criteria score and diagnostic cut-off level for plasmatic amino-terminal pro-brain natriuretic peptide (NT-proBNP) in diagnosis pediatric heart failure, by analyzing receiver operating characteristic (ROC) curve. plasma NT-proBNP measured 80 children diagnosed with failure according criteria, non-cardiogenic dyspnea healthy children. levels were then compared using an F-test. determined ROC curve analysis. results demonstrated that...
Abstract Background IBD has become a common chronic intestinal disease in China. Considering the important role of amino acid metabolism inflammatory diseases, inhibition sites may be effective alleviating UC (ulcerative colitis). SLC7A5 is involved progression UC, but mechanism its functional regulation still needs to investigated. In this study, we aimed clarify link among expression mTOR pathway activation and immunoregulation. Methods We previously discovered through high-throughput...
Both N6-methyladenosine (m6A) ribonucleic acid (RNA) methylation and ferroptosis regulators are demonstrated to have significant effects on the malignant clinicopathological characteristics of pancreatic adenocarcinoma (PAAD) patients. However, currently available clinical indexes not sufficient predict precise prognostic outcomes pf PAAD patients accurately. This study aims examine clinicopathologic features m6A RNA in predicting different types cancer.As foundation for this research,...
Age-related macular degeneration (AMD) is the most common blindness-causing disease among elderly. Under oxidative stress, low-density lipoprotein in outer layer of retina easily converted into oxidized (OxLDL), which promotes development choroidal neovascularization (CNV), main pathological change wet AMD. Liver X receptor (LXR), a ligand-activated nuclear transcription factor, regulates various processes related to CNV, including lipid metabolism, cholesterol transport, inflammation, and...
To evaluate the difference and correlation between concentrations of cytokines in aqueous humor eyes with macular edema secondary to diabetic retinopathy (DR) or retinal vein occlusion (RVO).This is a retrospective case control study. The samples were collected during intravitreal injection anti-vascular endothelial growth factor (VEGF) for patients diagnosed DR (DME) RVO (RVO-ME) at Xijing Hospital from August 2021 July 2022. Meanwhile, vitrectomy idiopathic hole (IMH) also served as...
Background and objective: An interaction between low-density lipoprotein level, lipid-lowering drugs, systemic lupus erythematosus (SLE) was reported by previous studies. However, whether drugs provided protective effect for reducing the risk of SLE unclear. We aimed to clarify this causal relationship through a drug-target Mendelian randomization (MR) study. Methods: Genetic instruments-single nucleotide polymorphism (SNPs)-were utilized proxy inhibition three...
B-type natriuretic peptide (BNP) is a cardiac neurohormone secreted from the ventricles in response to pressure overload.To evaluate optimal cutoff point of plasma BNP diagnosing congestive heart failure (CHF).We conducted prospective study 195 patients who were hospitalised with dyspnoea. Pulmonary capillary wedge (PCWP) was measured Swan-Ganz catheterisation and level obtained by rapid immunofluorescence assay all patients. PCWP >12 mmHg chosen as golden standard for left ventricular...
The role of inflammation in retinitis pigmentosa (RP) has been receiving additional attention. However, the association between and clinical manifestations complications RP is still unclear. This study aimed to evaluate neutrophil-to-lymphocyte ratio (NLR) complicated with cataract explore correlations NLR specific features RP.This retrospective included 79 patients (125 eyes) 63 age- sex-matched (63 age-related (ARC). Patients' ocular examination results were collected complete blood count...
To explore T cell-intrinsic mechanisms underpinning the mal-differentiation of tissue-resident memory (Trm) cells in patients with rheumatoid arthritis (RA).