A5013520470- Retinal Diseases and Treatments
- Cancer, Hypoxia, and Metabolism
- Anesthesia and Neurotoxicity Research
- Renal Diseases and Glomerulopathies
- Urological Disorders and Treatments
- Acute Kidney Injury Research
- Ureteral procedures and complications
- Cancer Cells and Metastasis
- Cardiac Imaging and Diagnostics
- Dialysis and Renal Disease Management
- Advanced MRI Techniques and Applications
- Organ Transplantation Techniques and Outcomes
- Pediatric Urology and Nephrology Studies
- Anesthesia and Pain Management
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Mechanical Circulatory Support Devices
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Burn Injury Management and Outcomes
- Lipid metabolism and biosynthesis
Xuzhou Medical College
2025
Air Force Medical University
2009-2024
Xijing Hospital
2009-2024
Jinan City People's Hospital
2021
Shandong First Medical University
2015-2021
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017-2019
Sichuan University
2008-2019
West China Hospital of Sichuan University
2008-2019
Chongqing Medical University
2005-2019
Second People’s Hospital of Yibin
2019
Lipid droplets (LDs) are a neutral lipid storage organelle that is conserved across almost all species. Many metabolic syndromes directly linked to the over-storage of lipids in LDs. The study LDs <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) has been difficult because lack specific LD marker proteins. Here we report purification and proteomic analysis <i>C. for first time. We identified 306 proteins, 63% these proteins were previously known be LD-proteins, suggesting similarity between...
Abstract Hypoxia plays an important role in the genesis and progression of renal fibrosis. The underlying mechanisms, however, have not been sufficiently elucidated. We examined p53 hypoxia-induced fibrosis cell culture (human rat tubular epithelial cells) a mouse unilateral ureteral obstruction (UUO) model. Cell cycle cells was determined by flow cytometry, expression profibrogenic factors RT-PCR, immunohistochemistry, western blotting. Chromatin immunoprecipitation luciferase reporter...
Accumulating evidence suggests that glucagon-like peptide-1 (GLP-1) and its analogues exert cardioprotective effects via modulating cardiomyocyte metabolism. Mitochondria play a pivotal role in the regulation of cell It was hypothesized treatment with exenatide, GLP-1 analogue, may by improving mitochondrial function an vitro model hypoxia/reoxygenation (H/R). H9c2 cells were employed to establish H/R. Exenatide added for 30 min prior exposure hypoxia. The receptor antagonist exendin‑(9‑39),...
<i>Background:</i> Vascular endothelial growth factor (VEGF) is upregulated by hypoxia and a major stimulatory for choroidal neovascularization. The upregulation of VEGF expression in response to occurs through hypoxia-inducible 1 (HIF-1), which transcription that regulates genes involved the hypoxia. HIF-1α inducible subunit HIF-1. <i>Aims:</i> To further define HIF-1 function angiogenesis explore novel approaches modulate neovascularization age-related macular...
Breast cancer resistance protein 1 (BCRP1/ABCG2) is used to identify the side population (SP) within a of cells, which enriched for stem and progenitor cells in different tissues. Here, we investigated role extracellular signal-regulated kinase (ERK) 1/2 signaling mechanisms underlying ischemic/hypoxic conditions kidney SP cells. Kidney were isolated using Hoechst 33342 dye-mediated fluorescein-activated cell sorting then incubated under hypoxia/reoxygenation (H/R) with or without verapamil,...
Abstract Background Postoperative neurocognitive disorder (PND) is a severe postoperative complication with no effective therapy that affects up to 19–52% of senior patients. Age and surgery type have been identified as risk factors. However, what caused the increased in elderly poorly understood. Methods We utilized PND model aged mice undergoing experimental laparotomy general anesthesia evaluate causal relationship between hyperhomocysteinemia susceptibility. was assessed by Novel Object...
Objectives The aim of this study was to evaluate the effects pulse high-volume hemofiltration (PHVHF) in patients with severe sepsis. Methods Twenty-two sepsis admitted XiJing hospital between January 2009 and 2010 were included present study. Patients randomly divided into control group (conventional treatment) PHVHF group. received 72 h treatment addition conventional after admission. conducted as follows: HVHF 85 ml/kg per hour for 6 followed by continuous venovenous 35 18 an AN69...
The aim of this study was to investigate the effect high-volume hemofiltration (HVHF) on ameliorating immune dysfunction in patients with severe acute pancreatitis (SAP).Twelve diagnosed SAP admitted intensive care unit general surgery, Jinling Hospital, from January 2004 December 2006 were included study. They assigned standard medical therapy group (SMT group, n=4) or HVHF (n=8) immediately after enrollment, a 1:2 ratio. SMT given treatment for SAP, while as well 72-hour initiated within 2...
To evaluate the correlation among changes in fundus autofluorescence (AF) measured using infrared AF (IR-AF) and short-wave length (SW-AF) with spectral-domain optical coherence tomography (SD-OCT) fluorescein angiography (FA) central serous chorioretinopathy (CSC).Two hundred twenty consecutive patients CSC were included. In addition to AF, assessed by means of SD-OCT FA. Abnormalities images IR-AF, SW-AF, FA analyzed correlated corresponding outer retinal alterations findings.Eyes...
Background Heparin anticoagulation (HA) is commonly employed for membrane therapeutic plasma exchange (mTPE). However, patients with increased bleeding risk, there were controversial opinions on the use of HA versus regional citrate (RCA) mTPE. Our present study aimed to evaluate efficacy and safety vs. RCA mTPE in risk.Methods Patients risk who underwent between 2014 2021 our center screened. Observations used as endpoints.Results A total 108 368 sessions included. Of included patients, 38...
This study aimed to evaluate the clinical effects of hemoperfusion plus continuous veno-venous hemofiltration in treatment patients with multiple organ failure after wasp stings and investigate its impacts on cytokines.A total 12 admitted Xijing Hospital were included present between January 2017 2019. All received addition conventional admission. Procedure was conducted as following: (2 h/day) followed by (22 for at least 5 days. Patients' features, serum laboratory tests, hemodynamic...
To explore the specific killing effect on prostate cancer cells of a dual cytosine deaminase (CD) and uracil phosphoribosyltransferase (UPRT) expression plasmid system controlled by prostate-specific membrane antigen (PSMA) promoter enhancer.The CD gene was used to construct recombinant antigen(promoter/enhancer)-CD (pPSMA(E/P)-CD). The regulatory function pPSMA(E/P) demonstrated detection enhanced green fluorescent protein (EGFP) in LNCaP cell line. Survival transfected with different...
Study Design. A randomized, in vivo study was performed to explore the skeletal muscle relaxation action site of sevoflurane. Objective. The aim this investigate sevoflurane by a modified selective anesthetics delivery rabbit model. Summary Background Data. and mechanisms caused were unclear, so model used. Methods. Sixteen male New Zealand White rabbits randomly assigned or sham group. In situ measurement train four, maximum single twitch, tetanic force left tibialis anterior repeatedly...
Background: Maintenance hemodialysis (MHD) patients are often admitted to the hospital for severe morbidities. Prolonged intermittent renal replacement therapy (PIRRT) is required during staying. There controversial opinions on use of arteriovenous fistula (AVF) as vascular access PIRRT in MHD patients. Methods: Patients with AVF who accepted our center between January 2014 and June 2021 were retrospectively screened. dysfunction patient mortality assessed endpoints. Univariate multivariate...