A5022379761- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- Microbial Community Ecology and Physiology
- RNA modifications and cancer
- Electrochemical Analysis and Applications
- Cancer-related gene regulation
- Proteoglycans and glycosaminoglycans research
- Inorganic Fluorides and Related Compounds
- Luminescence Properties of Advanced Materials
- Neuroinflammation and Neurodegeneration Mechanisms
- Mosquito-borne diseases and control
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Natural product bioactivities and synthesis
- Soil Carbon and Nitrogen Dynamics
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Calcium signaling and nucleotide metabolism
- Viral Infections and Vectors
- Gut microbiota and health
- Cancer Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Sirtuins and Resveratrol in Medicine
- Male Breast Health Studies
- Cancer, Stress, Anesthesia, and Immune Response
Southern Medical University
2017-2025
Northwestern Polytechnical University
2023-2025
Xuzhou Medical College
2015-2025
Shanghai Institute of Materia Medica
2025
Chinese Academy of Sciences
2025
Guangzhou University of Chinese Medicine
2025
Nantong University
2024
Peng Cheng Laboratory
2024
Affiliated Hospital of Nantong University
2024
China Electronics Technology Group Corporation
2024
ABSTRACT Soil microbial diversity and community life strategies are crucial for nutrient cycling during vegetation restoration. Although the changes in topsoil communities restoration have been extensively studied, structure, strategies, function of subsoil remain poorly understood, especially regarding their role In this study, we conducted a comprehensive investigation soil community, assembly process, functional genes profiles (0–100 cm) across 36 year chronosequence (5, 15, 28, years)...
Macroautophagy/autophagy is a host natural defense response. Viruses have developed various strategies to subvert autophagy during their life cycle. Recently, we revealed that was activated by binding of Avibirnavirus cells. In the present study, report inhibition initiated PIK3C3/VPS34 via PDPK1-dependent AKT-MTOR pathway. Autophagy detection viral protein VP3 triggered at early stage replication. Subsequent interaction analysis showed CC1 domain disassociated PIK3C3-BECN1 complex direct...
PDPK1 (3-phosphoinositide dependent protein kinase 1) is a phosphorylation-regulated that plays central role in activating multiple signaling pathways and cellular processes. Here, this study shows turns on macroautophagy/autophagy as SUMOylation-regulated kinase. In vivo data demonstrate the SUMO modification of physiological feature brain it can be induced by viral infections. The SUMOylated regulates its own phosphorylation subsequent activation AKT1 (AKT serine/threonine 1)-MTOR...
Background: Chloroquine (CQ) has been extensively validated for its safety as an antimalarial drug. The treatment regimen combining CQ with 5-fluorouracil (5-FU) demonstrated promising antitumor effects in both vitro and animal models. However, the clinical application of this combination therapy still faces numerous challenges, primarily due to unelucidated mechanistic underpinnings. Methods: We synergistic effect using N-acetylcysteine. Subsequently, we employed lysosomal pH probes...
Abstract Grazing exclusion and land abandonment are commonly adopted to restore degraded ecosystems in semiarid arid regions worldwide. However, the temporal variation soil- versus root-associated microbiome over plant species turnover during secondary succession has rarely been quantified. Using chronosequence restored from fenced grassland abandoned farmlands on Loess Plateau of China, we characterized dynamics host with different dominance statuses 0 40 years. Our results revealed that...
Callicarpa giraldii Hesse ex Rehd. is an endemic plant in China and has long been used as a traditional medicine several provinces. Although the reported to contain flavonoids, triterpenes, alkaloids, this study represents first report of isolation phyllocladane-type diterpenoids, relatively rare class compounds. In study, 18 new diterpenoids (7–24) were isolated structurally elucidated, including eight uncommon 3,4-seco (15–22) two unusual diterpene dimers (23–24), along with six known...
<div class="section abstract"><div class="htmlview paragraph">Nowadays, the rapidly developing Connected and Autonomous Vehicle (CAV) provides a new mode of intersection vehicle cooperative control, which can optimize trajectories signal phases in real time reduce delays through advantages vehicle-road information interaction high controllability CAV. In this paper, Jintong West Road Guanghua Beijing is taken as research object, trajectory constraints, acceleration speed safe...
ABSTRACT As age increases, there are structural and functional alterations in the peripheral nervous system (PNS), significantly affecting movement, sensation autonomic function. Understanding characteristics mechanisms of PNS aging is crucial for preventing treating related diseases. This study employed single‐cell sequencing technology to analyse dorsal root ganglia (DRG) sciatic nerve (SN) rats, comparison with adult rats. The research investigated underlying degeneration, revealing...
To analyze and compare prospectively the curative effects between mammotome-assisted minimally invasive resection (MAMIR) traditional open surgery (TOS) for gynecomastia in Chinese male patients, a total of 60 patients suffering from grade I II gynecomastia, evaluated by automated whole-breast ultrasound (AWBU), were recruited randomly divided into TOS MAMIR groups (each n = 30). The postoperative scar size, healing time, patient hospital stay, satisfaction, pain, complications including...
Breast cancer stem cells (BCSCs) have been suggested to contribute chemotherapeutic resistance and disease relapse in breast cancer. Thus, BCSCs represent a promising target developing novel treatment strategies. Mitochondrial dynamics were recently highlighted as an available approach for targeting BCSCs. In this study, three-dimensional (3D) cultured cell spheres model was constructed. functions analyzed by flow cytometry confocal microscopy. We demonstrated that the protein levels of FIS...
Patient-derived xenografts (PDX) have a biologically stable in tumor architecture, drug responsiveness, mutational status and global gene-expression patterns. Numerous PDX models been established to date, however their thorough characterization regarding the formation rates of growth remains challenging task. Our study aimed provide more detailed information for establishing successfully effectively.We transplanted four different types solid tumors from 108 Chinese patients, including 21...
ORP5 is a transmembrane protein anchored to the endoplasmic reticulum, which mainly functions as lipid transporter and has reportedly been linked cancer. However, specific mechanism of action in cervical cancer (CC) unclear. In this study, we found that promotes migration invasive ability CC cells vitro vivo. addition, expression was reticulum stress, encouraged metastasis by inhibiting stress. Mechanistically, inhibited stress stimulating ubiquitination proteasomal degradation SREBP1 reduce...