A5100625596- Autophagy in Disease and Therapy
- Diet and metabolism studies
- MicroRNA in disease regulation
- Respiratory viral infections research
- Vitamin C and Antioxidants Research
- Musculoskeletal pain and rehabilitation
- COVID-19 and healthcare impacts
- China's Ethnic Minorities and Relations
- Cancer Cells and Metastasis
- Microtubule and mitosis dynamics
- Cytokine Signaling Pathways and Interactions
- Mechanical Circulatory Support Devices
- Lipid metabolism and biosynthesis
- Hip disorders and treatments
- Peroxisome Proliferator-Activated Receptors
- Health disparities and outcomes
- Tryptophan and brain disorders
- Streptococcal Infections and Treatments
- S100 Proteins and Annexins
- Soybean genetics and cultivation
- Influenza Virus Research Studies
- Adenosine and Purinergic Signaling
- Spine and Intervertebral Disc Pathology
- Calcium signaling and nucleotide metabolism
- Ginseng Biological Effects and Applications
Wuhan University
2024-2025
Weatherford College
2024
Renmin Hospital of Wuhan University
2024
Third Affiliated Hospital of Harbin Medical University
2023
Shanghai Children's Medical Center
2022-2023
Harbin Medical University
2023
Shanghai Jiao Tong University
2016-2022
Ruijin Hospital
2022
Shanghai University of Traditional Chinese Medicine
2022
Yunnan University
2002-2022
Given the increasing need of long-term care and low occupancy rate nursing homes in Shanghai, this study attempts to explore what factors influence older people's intention enrol homes.A cross-sectional observational based on theory reasoned action was conducted. Survey data were collected from subjects during face-to-face interviews. Structural equation modelling employed for analysis.This conducted six community health service centres China. Two selected urban, suburban rural areas,...
Breast cancer stem cells (BCSCs) have been suggested to contribute chemotherapeutic resistance and disease relapse in breast cancer. Thus, BCSCs represent a promising target developing novel treatment strategies. Mitochondrial dynamics were recently highlighted as an available approach for targeting BCSCs. In this study, three-dimensional (3D) cultured cell spheres model was constructed. functions analyzed by flow cytometry confocal microscopy. We demonstrated that the protein levels of FIS...
Drug resistance is a critical factor responsible for the recurrence of non-small cell lung cancer (NSCLC). Previous studies suggest that curcumin acts as chemosensitizer and radiosensitizer in human malignancies, but underlying mechanism remains elusive. In present study, we explored how regulates expression miR-142-5p sensitizes NSCLC cells to crizotinib. We found significantly downregulated tissue samples lines. Curcumin could increase crizotinib cytotoxicity by epigenetically restoring...
Total flavonoids of <em>Rhizoma Drynariae</em> (TFRD), extracted from the kidney‑tonifying Traditional Chinese medicine Drynariae</em>, can be effective in treating osteoporosis, bone fractures and defects. However, pharmacological effects TFRD on specific vessel subtype CD31<sup>hi</sup>Emcn<sup>hi</sup> during distraction osteogenesis (DO) remains unclear. The present study aimed to investigate vessels a rat model DO. In study, tibial DO models were established using 60 rats with rate 0.2...
The current study aimed to investigate the potential role of astragaloside IV (AS-IV) in improving cellular lipid deposition and its underlying mechanism. A fatty liver cell model was established by treating hepatoma cells with palmitic acid. AS-IV SC79 were used for treatment. Oil Red O staining applied detect intracellular deposition, transmission electron microscopy utilized assess autophagosome formation. Immunofluorescence double determine microtubule-associated proteins 1A/1B light...
Objectives Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are prevalent functional gastrointestinal disorders (FGIDs). In this study we aimed to explore the causal association between physical activity or sedentary behavior risk of FD IBS. Methods Mendelian randomization (MR) analysis was employed. Candidate genetic instruments for were retrieved from latest published Genome‐Wide Association Study (GWAS), which included up 703 901 participants. Summary‐level GWAS data (8 875...
The difference between childhood infections with avian influenza viruses A(H5N1) and A(H7N9) remains an unresolved but critically important question. We compared the epidemiological characteristics of 244 H5N1 41 H7N9 cases (<15 years old), as well cluster two viruses. Our findings revealed a higher proportion than (31.1% vs. 6.4%, p = 0.000). However, groups did not differ significantly in age (median age: 5.0 5.5 y, 0.0651). clustered was greater among children infected [46.7% (71/152)...
Tonifying kidney therapy consisting of tonifying yang and yin is the basic principle Chinese medicine in treating segmental bone defects (SBDs). Previous studies have demonstrated presence differences between metabolism osteoporosis distraction osteogenesis models. However, whether difference two methods repair for induced membrane (IM) technique occurs or what remain unclear. Angiogeneic‐osteogenic coupling plays an important role couples angiogenesis with later during IM process. This...
The pathogenesis of infective endocarditis (IE) is a complex process which can include tissue damage to the valves during bacteraemia, pathogen adherence leading formation non-bacterial thrombotic vegetations, platelet aggregation at sites damage, and variety biological interactions between pathogens host matrix molecules (e.g. platelets).1,2 In past few decades, incidence IE has increased significantly, may be result an aging population, delayed diagnosis valvular heart disease, even new...
摘要:
To investigate the protective effects and underlying mechanisms of Vitamin C (VC) on hydrocortisone (HC)-induced cell injury in human microvascular endothelial cells (HMEC).Cell viability was measured by CCK-8 assay expression Best-3 detected Western blotting assay. The experiment divided into normal control, HC group, VC treatment groups, + siRNA pcDNA3.1 group.HC inhibited HMEC-1 balanced with lower a dose-dependent manner. Conversely, promoted paralleled to higher Silencing viability,...
Purpose: To study the effect of mTOR inhibitor, everolimus, on glioma cell proliferation, autophagy, and drug sensitivity to temozolomide (TMZ).Methods: Human lines were cultured in vitro, effects different concentrations everolimus proliferation brain glial cells determined using CCK-8 method. The levels autophagy protein assayed by western blot method.Results: results analysis showed that inhibited a time- concentration-dependent manner. Western expression proteins, LC3-II LC3-II/I,...
Objective: To evaluate the effectiveness of ECMO theory and simulation training organized by Shanghai Children's Medical Center for pediatric intensive care staff in China. Method: From April 2020 to May 2023, 167 medical from 32 hospitals across country participated our training, including 66 doctors, 95 nurses 6 perfusionists. The traning includes pre-test, theoretical study, practice, post-test follow up. difference between pre- post- tests was compared. Results: median score pre-test 50...
Abstract Background Burns are a type of injuries, caused by unintentional exposure to substances high temperature, including hot liquid, solid, and objects radiating heat energy, placing burden not only on patients’ families but also national healthcare systems globally. It is difficult for policymakers clinicians formulate targeted management strategies burns because data current epidemiological patterns worldwide lacking. Methods Data were obtained from the Global Burden Disease (GBD) 2019...
Normal aging causes profound changes of structural degeneration and glucose hypometabolism in the human brain, even absence disease. In recent years, with extensive exploration topological characteristics related studies rats have begun to investigate. However, age-related alterations properties individual brain metabolic network remain unknown. this study, a total 48 healthy female Sprague-Dawley (SD) were used, including 24 young aged rats. We used Jensen-Shannon Divergence Similarity...