A5046888414- Andrographolide Research and Applications
- Phytochemicals and Medicinal Plants
- Natural product bioactivities and synthesis
- Pharmacological Effects of Medicinal Plants
- Bone Metabolism and Diseases
- Medicinal Plants and Neuroprotection
- Inflammasome and immune disorders
- Plant Toxicity and Pharmacological Properties
- Ion Channels and Receptors
- Biological Activity of Diterpenoids and Biflavonoids
- Plant biochemistry and biosynthesis
- Sesquiterpenes and Asteraceae Studies
- Phytochemistry and Biological Activities
Shanghai Institute of Materia Medica
2021-2025
Chinese Academy of Sciences
2021-2025
University of Chinese Academy of Sciences
2021-2022
A series of pyrazole-fused betulinic acid (BA) derivatives were designed and synthesized by replacing the carboxyl group at C-17 with aliphatic amine, amide, urea groups. The suppressive effects compounds on osteoclast (OC) formation inflammatory cytokine production evaluated murine macrophages, RAW264.7 cells, conditioned receptor activator for nuclear factor-κB ligand (RANKL)/macrophage colony stimulating factor (M-CSF) or lipopolysaccharide (LPS), respectively. Results showed that,...
Callicarpa giraldii Hesse ex Rehd. is an endemic plant in China and has long been used as a traditional medicine several provinces. Although the reported to contain flavonoids, triterpenes, alkaloids, this study represents first report of isolation phyllocladane-type diterpenoids, relatively rare class compounds. In study, 18 new diterpenoids (7–24) were isolated structurally elucidated, including eight uncommon 3,4-seco (15–22) two unusual diterpene dimers (23–24), along with six known...
Physalis minima is a medicinal and edible plant in China. In this study, 22 new withaphysalins, including novel 1(10 → 6)abeo-14β-hydroxy one (1) other 15 unusual 14β-hydroxy ones (3-4, 6-17, 19), were isolated from the whole herbs of P. together with two known analogues (23-24). Their structures established by extensive analysis high-resolution electrospray ionization mass spectrometry, IR, 1D 2D NMR spectroscopic data. absolute configurations determined electronic circular dichroism (ECD)...
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