A5072498541- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Medication Adherence and Compliance
- Spondyloarthritis Studies and Treatments
- Pharmaceutical industry and healthcare
- Genetic Associations and Epidemiology
- Drug-Induced Hepatotoxicity and Protection
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Structural Engineering and Vibration Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Mast cells and histamine
- Tryptophan and brain disorders
- Poisoning and overdose treatments
Air Force Medical University
2023-2024
Xijing Hospital
2023-2024
University of Southern California
2018
Abstract A number of randomized controlled trials and real‐world studies have demonstrated the effectiveness safety secukinumab in treatment moderate to severe psoriasis, whereas data on a large cohort Chinese patients long‐term practice are limited. This was single‐centre, uncontrolled, single‐arm, prospective, observational study that included 254 psoriatic treated with between September 2019 December 2022. Demographic clinical characteristics patients, response adverse events were...
Psoriasis is a chronic, refractory inflammatory skin disease, with high prevalence of psychiatric comorbidities, including depression, anxiety, and even suicidality, which may in turn initiate or exacerbate inflammation. However, the causal relationships between these comorbidities remain unclear. To investigate cause-effect psoriasis mental disorders we conducted bidirectional two-sample Mendelian randomization (MR) study utilizing summary statistics from most comprehensive genome-wide...
Abstract Bullous pemphigoid (BP) is the most prevalent autoimmune vesiculobullous skin illness that tends to affect elderly. Growing evidence has hinted a correlation between BP and neurological diseases. However, existing observational studies contained inconsistent results, causality direction of their relationship remain poorly understood. To assess causal disorders, including Alzheimer's disease (AD), multiple sclerosis (MS), Parkinson's (PD), stroke. A bidirectional two‐sample Mendelian...
Abstract Psoriasis is a common chronic inflammatory skin disease with complex pathogenesis involving immune system dysregulation and inflammation. Previous studies have indicated that metabolic abnormalities are closely related to the development occurrence of psoriasis. However, specific involvement amino acid metabolism in psoriasis remains unclear. In this study, we conducted comprehensive analysis pathway changes patients using transcriptome data, genome‐wide association (GWASs)...
Abstract Background Skin barrier dysfunction may both initiate and aggravate skin inflammation. However, the mechanisms involved in inflammation process remain largely unknown. Objectives We sought to determine how enhances molecular mechanisms. Methods defect mice were established by tape stripping or topical use of acetone on wildtype mice, filaggrin deficiency. RNA-Seq was employed analyse differentially expressed genes with defects. Primary human keratinocytes transfected formylpeptide...