A5026850052- Genetics, Aging, and Longevity in Model Organisms
- Muscle Physiology and Disorders
- Cutaneous lymphoproliferative disorders research
- Dermatologic Treatments and Research
- Lymphoma Diagnosis and Treatment
- Spaceflight effects on biology
- Histiocytic Disorders and Treatments
- Parvovirus B19 Infection Studies
- Hair Growth and Disorders
- Tumors and Oncological Cases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genital Health and Disease
- Laser Applications in Dentistry and Medicine
- Dermatological and Skeletal Disorders
- Veterinary Pharmacology and Anesthesia
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Systemic Lupus Erythematosus Research
- Exercise and Physiological Responses
- Circadian rhythm and melatonin
- Rabbits: Nutrition, Reproduction, Health
- Infectious Diseases and Mycology
- Cancer Genomics and Diagnostics
- T-cell and Retrovirus Studies
- Polyomavirus and related diseases
- Cancer and Skin Lesions
Michigan Medicine
2021-2024
University of Michigan
2017-2024
Henry Ford Health System
2020
Illinois State University
2016-2019
IFN-γ enhances keratinocyte death in lichen planus.
Significance Duchenne muscular dystrophy is a degenerative disease affecting tens of thousands people in the United States alone. Much remains unknown about disease, including chain events that links loss dystrophin to muscle death, and extent which exercise might be able protect degenerating muscles. We used nematode Caenorhabditis elegans show sarcoplasmic calcium dysregulation takes place dystrophic muscles before other overt signs damage manifest. When placed assays altered activity by...
Abstract Background Skin barrier dysfunction may both initiate and aggravate skin inflammation. However, the mechanisms involved in inflammation process remain largely unknown. Objectives We sought to determine how enhances molecular mechanisms. Methods defect mice were established by tape stripping or topical use of acetone on wildtype mice, filaggrin deficiency. RNA-Seq was employed analyse differentially expressed genes with defects. Primary human keratinocytes transfected formylpeptide...
Natural killer (NK)/T-cell lymphoma is a rare subtype of non-Hodgkin (NHL) associated with Epstein-Barr virus (EBV).1-4 While NK/T-cell comprises only 5%-10% NHL in the United States, it more common Asia and Central South America, accounting for 15%-20% NHL, less Europe, 1% population NHL.1,5-7 most commonly involves nasopharynx nasal cavity; however, might also affect perinasal skin.1,4,8 This type lymphoma, known as extranodal (ENKTCL), formation tumor on midface, symptoms obstruction,...
Langerhans cell histiocytosis (LCH) is characterized by clonal proliferation of histiocytes accumulating in a variety organs, most often the skin, bone, lungs, and pituitary gland.1,2 Although LCH commonly observed children, it can rarely affect adults.3 While be skin-limited, patients with cutaneous disease have multisystem involvement, which associated poorer prognosis.2 We report case an adult man history liver transplant presenting intergluteal rash that was diagnosed as LCH.
Psammoma bodies (PBs) are concentric, lamellated calcifications commonly observed in malignancies such as papillary thyroid carcinoma and serous of the ovary which they may serve prognostic value. PBs rare cutaneous squamous cell (cSCC), with only 1 previously reported case. Here, we present 3 cases cSCC displaying PBs. One case occurred setting end-stage renal disease, whereas other 2 were patients who did not have comorbid conditions that might predispose to hypercalcemia dystrophic...
Abstract: Atypical Spitz tumor (AST) is a melanocytic proliferation that shares histopathologic features of nevus and spitzoid melanoma. Distinction AST from melanoma critical because the majority ASTs will follow an indolent course. Array-based comparative genomic hybridization (aCGH) has been suggested as potential tool for evaluating malignant in tumors. We present case 52-year-old woman with which aCGH was crucial guiding correct diagnosis management. The patient first presented...
ABSTRACT Duchenne muscular dystrophy (DMD) is a genetic disorder caused by loss of the protein dystrophin. In humans, DMD has early onset, causes developmental delays, muscle necrosis, ambulation, and death. Current animal models have been challenged their inability to model onset severity disease. Thus it remains unresolved if increased sarcoplasmic calcium observed in dystrophic muscles follows or leads mechanical insults muscle’s disrupted contractile machinery. This knowledge important...