A5053387742- Sexual function and dysfunction studies
- Genital Health and Disease
- RNA Research and Splicing
- Hormonal and reproductive studies
- Sperm and Testicular Function
- Urinary Bladder and Prostate Research
- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- Urological Disorders and Treatments
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Metal Alloys Wear and Properties
- COVID-19 Impact on Reproduction
- Sexuality, Behavior, and Technology
- Pelvic floor disorders treatments
- Genetic and Kidney Cyst Diseases
- Migraine and Headache Studies
- CRISPR and Genetic Engineering
- COVID-19 and healthcare impacts
- Prostate Cancer Treatment and Research
- Gynecological conditions and treatments
- Urinary and Genital Oncology Studies
- Urologic and reproductive health conditions
- Circular RNAs in diseases
- High Temperature Alloys and Creep
Shandong University
2015-2022
Shandong Provincial Hospital
2006-2022
Shandong First Medical University
2020-2022
Second Hospital of Shandong University
2015-2021
Abstract Background Since SARS‐CoV‐2 infection was first identified in December 2019, the novel coronavirus‐induced pneumonia COVID‐19 spread rapidly and triggered a global pandemic. Recent bioinformatics evidence suggested that angiotensin‐converting enzyme 2—the main cell entry target of SARS‐CoV‐2—was predominantly enriched spermatogonia, Leydig Sertoli cells, which suggests potential vulnerability male reproductive system to infection. Objectives To identify RNA seminal plasma determine...
In this paper, we investigated the effects of matrix and precipitates in Cr-Ni-Mo-V rotor steel on its mechanical properties after water quenching tempering (450–700 °C). The results indicate that microstructure can be significantly adjusted by changing temperature. An excellent combination tensile strength (1028.608 MPa) elongation (19%) was obtained upon at 650 °C. This is attributed to martensite lath with a high dislocation density, solid solution strengthening effect spherical Mo2C VC...
Prostate cancer (PCa) is the second most frequently diagnosed male cancer, and no treatments exist for effective inhibition of metastatic spread PCa. Long non-coding RNA (lncRNA) plays key roles in pathogenesis development various cancers through competing with endogenous RNAs (ceRNAs), but at present research on lncRNA functions PCa still very limited. Hence, this aspect was investigated using bioinformatics methods. Firstly, functional lncRNA-mediated ceRNA network associated constructed...
Abstract Objectives The aim of the study was to investigate ability blood lipid parameters predict discrimination arteriogenic erectile dysfunction (ED). Materials and methods 260 subjects with ED 60 healthy controls were enrolled. Eight parameters, including total cholesterol (TC), triglycerides (TG), LDL‐C, HDL‐C, non‐HDL‐C, TC/HDL ratio, TG/HDL LDL/HDL together other plasma biomarkers like sex hormones measured in all participants. Nocturnal penile tumescence (NPT), color Doppler...
To assess the correlation between penile hypersensitivity and premature ejaculation (PE), a total of 420 consecutive subjects attending our andrologic clinic for suspected PE were enrolled. The entire cohort was asked to complete self-report intravaginal latency time (IELT) by stopwatch. According IELT, classified into 3 groups. Vibratory thresholds recorded at glans penis shaft using biothesiometer. We found that vibratory in significantly lower both mild severe group than control (3.81 ±...
Background: Since SARS-CoV-2 infection was first identified in December 2019, the novel coronavirus induced pneumonia spread rapidly and triggered a global pandemic. Recent bioinformatics evidence reported that angiotensin converting enzyme 2 (ACE2) predominantly enriched spermatogonia, leydig Sertoli cells, suggesting potential risk of male reproductive system to be vulnerable attack. Methods: From February 26 April 2, 2020, 23 COVID-19 patients were recruited this study. The clinical...
Background: Bladder cancer (BLCA) is the major tumor of urinary system, and immune-related genes (IRGs) contribute significantly to its initiation prognosis. Results: A total 51 prognostic IRGs associated with overall survival were identified. Functional enrichment analysis revealed that these actively involved in tumor-related functions pathways. Using multivariate Cox regression analysis, we detected 11 optimal (ADIPOQ, PPY, NAMPT, TAP1, AHNAK, OLR1, PDGFRA, IL34, MMP9, RAC3, SH3BP2). We...
The aim of our study was to investigate the role platelet parameters including mean volume (MPV) and count (PC) in pathogenesis penile arteriogenic erectile dysfunction (ED) evaluate association between ED. There were 244 patients with ED (based on International Index Erectile Function [IIEF]-5 ≤21) 60 healthy controls (IIEF-5 >21) enrolled. All participants asked undergo a laboratory examination, vascular function evaluated using color Doppler ultrasonography (pDUS). Among these patients,...
This study aimed to describe endoscopic anatomy of the seminal tract and summarize our experience transutricular vesiculoscopy (TSV) guided by real-time transrectal ultrasonography (TRUS) in managing persistent hematospermia. A total 281 consecutive patients with hematospermia who underwent TSV or without TRUS were enrolled this single-center, prospective, observational study. The median follow-up period was 36.5 (range: 8.0-97.5) months. successfully performed 272 (96.8%) patients. approach...
The present study aimed to investigate the potential mechanisms used during signal transduction by M3 muscarinic acetylcholine receptor (CHRM3) in prostate cancer. microarray datasets of GSE3325, including 5 clinically localized primary cancers and 4 benign tissues, were downloaded from Gene Expression Omnibus database. differentially‑expressed genes (DEGs) cancer tissues compared with controls screened using Limma package. Ontology pathway enrichment analyses performed Database for...
Bladder spasm is a common side effect of urological surgery. Main treatment modalities include opioids or anticholinergic medication; however, bladder spasms still occur even after these interventions. Recent studies indicate that transcutaneous stimulation the foot can result in 50% increase capacity healthy adults, and inhibit detrusor overactivity spinal cord injured patients. In this study, we examined effects electrical on related symptoms. Sixty-six male patients who underwent prostate...
Penile hypersensitivity is one of the main pathological mechanisms premature ejaculation. However, little known about neurophysiological mechanism penile peripheral nerve sensitization. Piezo Type Mechanosensitive Ion Channel Component 2 (PIEZO2), was recently identified as a mechanically sensitive channel.This study explored possible neural PIEZO2 action in ejaculation using molecular biology and electrophysiology approaches.One hundred seventy male rats 85 female were recruited. The...
The aim of this study is to evaluate the benefits laparoscopic Doppler ultrasound (LDU) application during varicocelectomy (LV), and compare surgical outcomes complications between LDU-assisted LV (LDU-LV) conventional for infertile patients with varicoceles; 147 were randomly divided into two groups. Operative postoperative parameters, semen pregnancy rate compared. There no differences in baseline demographics. operative time was significantly longer LDU-LV group than group. incidence...
ObjectiveThe deoxyribonucleic acid-repair protein O6-methylguanine-deoxyribonucleic acid methyltransferase is a major determinant of resistance cells to various alkylating drugs. Its expression profile different in cancer types. Here, we studied the and function clear cell renal carcinoma.
The influence of tempering temperature on the microstructure and mechanical properties Cr–Ni–Mo–V rotor steel for large rotors was investigated. characterized by scanning electron microscope, transmission microscope X-ray diffraction, were tested uniaxial tensile test. results show that as increases from 450 ℃ to 700 ℃, strength first decreases, then decreases again, plasticity gradually increases. main reason is with increase temperature, gradual recovery recrystallization lat martensite...
Superior mesenteric arterio-venous (SMA-V) fistulas are rare. They usually associated with penetrating abdominal trauma or gastrointestinal surgery. We report a patient, who presented recurrent mild bleeding and severe distension for 3 months after small bowel resection acute abdomen. A machinery-type bruit was audible in the epigastrium. Oesophageal varices were seen on gastroscopy. SMA-V fistula diagnosed an angiogram large vein CT. The patient had successful laparotomy ligation of feeding...
The primary objective of this cross-sectional study aimed at evaluating serum levels homocysteinemia (Hcy) in a cohort erectile dysfunction (ED) patients, and assessing the correlation between Hcy vasculogenic ED.A total 119 Chinese patients presenting with ED [International Index Erectile Function (IIEF)-5≤21] were enrolled study. whole was asked to complete IIEF-5 questionnaire blood analysis. A detailed medical history, physical examination, nocturnal penile tumescence (NPT) tests color...
Robertsonian translocation between chromosomes 13 and 14 is reported to be a cause of male infertility. Here, we established an iPSC line (HRMSDUi001-A) from azoospermic patient with 45,XY,der(13;14)(q10;q10) karyotype. Peripheral blood mononuclear cells were reprogrammed generate hiPSCs by non-integrating delivery OCT4, SOX2, KFL4 MYC. The expressed pluripotency markers, could differentiate into three germ layers in vitro, carried
Objective To compare the surgical outcomes and complications between laparoscopic Doppler ultrasound assisted varicocelectomy (LDU-LV) conventional LV for infertile patients with varicoceles. To examine microanatomy of spermatic cord within suprainguinal portion.