A5025907738- Congenital Heart Disease Studies
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Elasticity and Material Modeling
- Pregnancy and preeclampsia studies
- Orthopaedic implants and arthroplasty
- Cardiovascular Health and Disease Prevention
- Aortic Disease and Treatment Approaches
- Cardiac and Coronary Surgery Techniques
- Shape Memory Alloy Transformations
- Peripheral Artery Disease Management
- Cardiac Structural Anomalies and Repair
- Hemodynamic Monitoring and Therapy
- Pulmonary Hypertension Research and Treatments
- Aortic aneurysm repair treatments
- Titanium Alloys Microstructure and Properties
- Total Knee Arthroplasty Outcomes
- Maternal and fetal healthcare
- Cardiac Imaging and Diagnostics
- Prenatal Screening and Diagnostics
- Cardiovascular Issues in Pregnancy
- Intracranial Aneurysms: Treatment and Complications
- Osteoarthritis Treatment and Mechanisms
Politecnico di Milano
2016-2025
University of Ioannina
2022
Clemson University
2012-2017
University of Michigan
2016-2017
Medical University of South Carolina
2012-2017
University College London
2011-2017
Great Ormond Street Hospital
2011-2017
Collaborative Group (United States)
2016
Institut national de recherche en informatique et en automatique
2016
Fondazione Toscana Gabriele Monasterio
2014
Hypoplastic left heart syndrome is the most common lethal cardiac malformation of newborn. Its treatment , apart from transplantation Norwood operation. The initial procedure for this staged repair consists reconstructing a circulation where single outlet provides systemic perfusion and an interpositioning shunt contributes blood flow to lungs. To better understand unique physiology, computational model was constructed on basis compartmental analysis. Influences diameter, pulmonary vascular...
Color Doppler sonography was used to study umbilical and ductus venosus (DV) flow in 137 normal fetuses between 20 38 wk of gestation. Hepatic flows were also evaluated. In all parts the venous circulation examined, blood increased significantly with advancing gestational age. The weight-specific amniotic did not change during gestation (120 ± 44 ml · min −1 kg ), whereas DV decreased (from 60 17 ). percentage shunted through 40% 15%); consequently, liver increased. right lobe changed from...
The function of articular cartilage is to support and distribute loads provide lubrication in the diarthrodial joints. Cartilage described by proper mechanical rheological properties, strain depth‐dependent, which are not completely assessed. Unconfined confined compression commonly used evaluate Young's modulus (E) aggregate (H A ), respectively. Poisson's ratio (ν) can be calculated indirectly from equilibrium data, or using biphasic indentation technique; it has recently been optically...
Combining bilateral pulmonary artery banding with arterial duct stenting, the hybrid approach achieves stage 1 palliation for hypoplastic left heart syndrome different flow characteristics than those after surgical Norwood procedures. Accordingly, we used computational modeling to assess some of these differences, including influence on systemic and cerebral oxygen deliveries.A 3-dimensional model was developed by finite volume method, along models operation a modified Blalock-Tausig or...
The objective of this work is to perform a virtual planning surgical repairs in patients with congenital heart diseases--to test the predictive capability closed-loop multi-scale model. As first step, we reproduced pre-operative state specific patient univentricular circulation and bidirectional cavopulmonary anastomosis (BCPA), starting from patient's clinical data. Namely, by adopting approach, boundary conditions at inlet outlet sections three-dimensional model were automatically...
Reduced exercise capacity is nearly universal among Fontan patients, though its etiology not yet fully understood. While previous computational studies have attempted to model exercise, they did account for global physiologic mechanisms nor directly compare results against clinical and data.In this study, we developed a protocol simulate lower-body using closed-loop lumped-parameter describing the entire circulation. We analyzed data from cohort of incorporated findings literature,...
Computational models of cardiovascular physiology can inform clinical decision-making, providing a physically consistent framework to assess vascular pressures and flow distributions, aiding in treatment planning. In particular, lumped parameter network (LPN) that make an analogy electrical circuits offer fast surprisingly realistic method reproduce the circulatory physiology. The complexity LPN vary significantly account, for example, cardiac valve function, respiration, autoregulation,...
In patients with congenital heart disease and a single ventricle (SV), ventricular support of the circulation is inadequate, staged palliative surgery (usually 3 stages) needed for treatment. various surgical stages individual differences in are important patient-specific planning ideal. this study, an integrated approach between clinicians engineers has been developed, based on multi-scale models, here applied to predict stage 2 outcomes. This involves four distinct steps: (1) collection...
Despite their success, stenting procedures are still associated to some clinical problems like sub-acute thrombosis and in-stent restenosis. Several studies associate these phenomena a combination of both structural hemodynamic alterations caused by stent implantation. Recently, numerical models have been widely used in the literature investigate but always from either purely or fluid dynamic point view. The aim this work is implementation sequential provide better understanding coronary...
Computational fluid dynamics (CFD) can have a complementary predictive role alongside the exquisite visualization capabilities of 4D cardiovascular magnetic resonance (CMR) imaging. In order to exploit these (e.g., for decision-making), it is necessary validate computational models against real world data. this study, we sought acquire CMR flow data in controllable, experimental setup and use corresponding model. We applied paradigm case congenital heart disease, namely, transposition great...
Objectives: A 3D computational model has been implemented for the evaluation of hemodynamics double orifice repair. Critical issues surgical decision making and echo-Doppler results procedure are investigated. Methods: parametric double-orifice mitral valve based on finite elements constructed from clinical data. Nine different geometries were investigated, corresponding to three total inflow areas (1.5, 2.25 3 cm2) configurations (two equal orifices, two orifices areas, i.e. one twice as...
Abstract Abstrad–This paper deals with an effective method for the prediction of kinetic parameters H-abstraction reactions from hydrocarbon species. The reactivity complex molecules is obtained starting a large set well defined experimental rate values small radicals and as basis. making use proper analogy rules limited number reference parameters. This empirical allows generalization extension previous work. Most predicted agree reasonably literature constants, when available. These can be...
This work was motivated by the problems of analysing detailed 3D models vascular districts with complex anatomy. It suggests an approach to prescribing realistic boundary conditions use in order obtain information on local as well global haemodynamics. A method developed which simultaneously solves Navier-Stokes equations for and a non-linear system ordinary differential information. is based principle that anatomically model cardiovascular district can be achieved using finite element...
Abstract Goal of this article is to present a detailed kinetic scheme able describe large variety macroscopic experimental data related methane pyrolysis, partial oxidation and combustion. Due the importance C2 chemistry, comparisons for pyrolysis ethane, ethylene acetaldehyde are also reported. The main effort has been put in collecting unifying these knowledge into single comprehensive scheme. result analysis enlarge simulation capabilities general scheme; such model, expensive terms...