A5100733346- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Gallbladder and Bile Duct Disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- IgG4-Related and Inflammatory Diseases
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- MicroRNA in disease regulation
- Diabetes and associated disorders
- Bariatric Surgery and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic function and diabetes
- Appendicitis Diagnosis and Management
Changhai Hospital
2015-2024
Second Military Medical University
2015-2024
National Clinical Research Center for Digestive Diseases
2017-2024
Shanghai Institute of Hematology
2017-2024
Third Affiliated Hospital of Southern Medical University
2024
University of Amsterdam
2022
Amsterdam University Medical Centers
2022
Creative Commons
2022
National Natural Science Foundation of China
2022
Weatherford College
2022
OBJECTIVES: To investigate the potential risk factors for endoscopic retrograde cholangiopancreatography (ERCP) complications and to identify whether are different pancreatitis asymptomatic hyperamylasemia. METHODS: Consecutive ERCP procedures were studied at 14 centers in China from May 2006 April 2007. The after patients' first-only evaluated. Multivariate analysis based on was used factors. RESULTS: A total of 3,178 performed 2,691 patients. Overall, developed 213 (7.92%) patients, 116...
Abstract BACKGROUND Detection of pancreatic cancer (PaC), particularly at early stages, remains a great challenge owing to lack specific biomarkers. We sought identify PaC-specific serum microRNA (miRNA) expression profile and test its specificity sensitivity as biomarker in the diagnosis prognosis PaC. METHODS obtained samples from 197 PaC cases 158 age- sex-matched cancer-free controls. screened differentially expressed miRNAs with Illumina sequencing by synthesis technology using pooled...
Diseases of the stomach, including gastric cancer and peptic ulcer, are most common digestive diseases. It is impossible to visualize entire stomach with passive capsule currently used in practice because large size cavity. A magnetically controlled endoscopy (MCE) system has been designed explore stomach. We performed a prospective study compare accuracy detection focal lesions by MCE vs conventional gastroscopy (the standard method).We multicenter blinded comparing 350 patients (mean age,...
The overproduction of reactive oxygen species (ROS) is central to the progression inflammatory bowel disease (IBD), which may be potential therapeutic target. Prussian blue (PB) nanoparticles with good biosafety can act as an artificial nanozyme, effectively scavenging ROS. To date, PB-based nanomaterials have not been developed and utilized for treatment IBD. In this study, poly(vinylpyrrolidone)-modified (PPB) are constructed physiological stability by a simple efficient method. prepared...
Chronic gastritis is one of the most common findings at upper endoscopy in general population, and chronic atrophic epidemiologically associated with occurrence gastric cancer. However, current status diagnosis treatment China unclear. A multi-center national study was performed; all patients who underwent diagnostic for evaluation gastrointestinal symptoms from 33 centers were enrolled. Data including sex, age, endoscopic prospectively recorded. Totally 8892 included. At endoscopy, 4389,...
Psychosocial stress is a critical inducing factor of inflammatory bowel diseases (IBD), while autophagy novel central issue IBD development. The present study investigated the potential role in stress-related patients and animal model. correlation between psychosocial intestinal was determined 23 with IBD. Corticotropin-releasing hormone (CRH), well-established inducer stress, administrated dextran sulfate sodium (DSS)-induced mice lipopolysaccharide (LPS)-stimulated bone marrow-derived...
Recurrent bleeding from the small intestine accounts for 5 to 10% of cases gastrointestinal and remains a therapeutic challenge. Thalidomide has been evaluated treatment recurrent due small-intestinal angiodysplasia (SIA), but confirmatory trials are lacking.
Objective: To assess the feasibility and safety of magnetic-controlled capsule endoscopy (MCE) system for examination human stomach.Methods: This pilot study enrolled 34 healthy volunteers.All subjects swallowed MCE gas-producing powder gastric distention.An external robot was used to generate magnetic field manipulate inside stomach.The primary measurements included safety, preparation, maneuverability visualization mucosa.Results: Gastric preparation well accepted by there were no adverse...
The epidemiology of gastroesophageal reflux disease (GERD) has yet to be investigated using the symptomatic threshold criteria recommended by Montreal Definition. This study aimed determine prevalence symptom-defined GERD across five regions China, and investigate variables associated with GERD.A representative sample 18 000 adults (aged 18-80 years) were selected equally from rural urban areas in each region (n = 1800). According Definition, is present when mild symptoms heartburn and/or...
We developed a novel magnetic-controlled capsule endoscopy (MCE) system for use in the human stomach. The aim of current study was to compare diagnostic accuracy MCE with that standard gastroscopy gastric diseases.A total 68 patients were enrolled this self-controlled trial. Patients evaluated by both and gastroscopy. Gastroscopy performed 4 – 24 hours after completion examination.The positive percent agreement between 96.0 %, negative 77.8 %. overall 91.2 % kappa value 0.765 (P < 0.001). A...
Colorectal cancer (CRC) is a common malignant gastrointestinal tumor. In China, CRC the 5th most commonly diagnosed cancer. The vast majority of cases are sporadic and evolve with adenoma-carcinoma sequence. There mounting evidence indicating that gut microbiota inflammation play important roles in development although study results not entirely consistent. current study, we investigated changes CRC-associated bacteria plasma inflammatory factors their relationships based on data from...
The mechanisms associated with diabetes‑induced neuropathic pain are complex and poorly understood. In order to understand the involvement of spinal microglia activity in diabetic pain, present study investigated whether minocycline treatment is able attenuate using a rat model. Diabetes was induced single intraperitoneal injection streptozotocin (STZ). Minocycline then intrathecally administered rats. Paw withdrawal threshold (PWT) paw latency (PWL) were tested weekly. expression OX‑42,...
Diabetes mellitus (DM) is a common complication of chronic pancreatitis (CP) and increases the mortality. The identification risk factors for DM development may contribute to early detection potential reduction in patients with CP. Patients CP admitted Changhai Hospital (Shanghai, China) from January 2000 December 2013 were enrolled. Cumulative rates after onset calculated by Kaplan-Meier method. Risk diagnosis identified Cox proportional hazards regression model. A total 2011 During...