A5085301873- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Dementia and Cognitive Impairment Research
- Intracerebral and Subarachnoid Hemorrhage Research
- RNA regulation and disease
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health, Environment, Cognitive Aging
- Nuclear Receptors and Signaling
- Cancer Mechanisms and Therapy
- Gastrointestinal Tumor Research and Treatment
- Cardiovascular Health and Disease Prevention
- Congenital Heart Disease Studies
- Protease and Inhibitor Mechanisms
- Moyamoya disease diagnosis and treatment
- Lysosomal Storage Disorders Research
- Gastroesophageal reflux and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- FinTech, Crowdfunding, Digital Finance
- Dialysis and Renal Disease Management
- Neurological Disease Mechanisms and Treatments
- Eosinophilic Esophagitis
- Cerebrovascular and genetic disorders
Peking Union Medical College Hospital
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Renji Hospital
2020-2023
Shanghai Jiao Tong University
2020-2023
Nantong University
2022
Beijing Jiaotong University
2015
University at Albany, State University of New York
2007
For effective preventive strategies against GORD (gastro-esophageal reflux disease), we assessed the burden from 1990 to 2019. The of between and 2019 was evaluated globally, regionally, nationally. Using ASIR (age-standardized incidence), ASYLDs years lived with disabilitys), compared them GBD world population per 100,000. estimates were based on 95% uncertainty intervals (UIs). AAPC (average annual percent change) in incidence, YLDs, along prevalence rates associated CIs estimated. Data...
Recurrent bleeding from the small intestine accounts for 5 to 10% of cases gastrointestinal and remains a therapeutic challenge. Thalidomide has been evaluated treatment recurrent due small-intestinal angiodysplasia (SIA), but confirmatory trials are lacking.
ABSTRACT Introduction Young patients with ischemic stroke often present more complex etiologies and risk factors, making their long‐term prognosis particularly challenging. This study aims to investigate the identify factors associated recurrent cerebrovascular events unfavorable functional outcome in a prospective, single‐center cohort. Methods We consecutively enrolled young adults (aged 18–49) cohort at Peking Union Medical College Hospital (PUMCH) from March 2017 2023. Follow‐up was...
Intracranial atherosclerotic disease (ICAD) is a major cause of ischemic stroke in China, but the prevalence and prognosis asymptomatic ICAD detected using high-resolution magnetic resonance imaging (HR-MRI) largely unknown. The aim this study was to investigate order guide neurologists interpreting on HR-MRI.We included stroke-free participants from community-based prospective cohort (Shunyi participants) who underwent HR-MRI between July 2014 April 2016. were divided into two groups: those...
Abstract Background Small bowel vascular malformation disease (SBVM) is the most common cause of obscure gastrointestinal bleeding (OGIB). Several studies suggested that EGFL6 was able to promote growth tumor endothelial cells by forming vessels. To date, it remains unclear how promotes pathological angiogenesis in SBVM and whether a target thalidomide. Methods We took advantage plasma tissue samples compared expression between patients healthy people via ELISA Immunohistochemistry....
The etiology and risk factor profile of ischemic stroke in young adults are different from those older patients. However, current etiological classifications more applicable for the adults, posing a challenge to diagnosis patients with stroke. In this study, we applied modified categorization previously used International Pediatric Stroke Study (IPSS) describe profiles Chinese explore sex age differences distribution factors.This is single-center retrospective study. Patients aged 18-50...
A 47-year-old man, with a medical history of vitiligo, presented to Peking Union Medical College Hospital for evaluation progressive gait instability over period 10 months. He was initially noticed walk drunken and have difficulty performing accurate movements during goal-directed tasks. The patient also complained in speaking reported that objects appeared move back forth across his field vision. symptoms worsened, he could not without assistance the recent 2 There no preceding infection or...
Apolipoprotein E (APOE) is closely related to Alzheimer's disease and other age-related diseases. In recent years, several studies have shown an interaction of APOE by age on brain volume. However, validation in larger cohorts required.We explored the effect volumes a community-dwelling cohort.Inhabitants Shunyi District Beijing aged≥35 years were invited join this study from 2013 2016. The baseline assessments, genotyping magnetic resonance imaging performed. Neuroimaging small vessel...
Using whole-exome sequencing (WES) and high-resolution magnetic resonance imaging (HR-MRI), this study aimed at investigating the association between RNF213 rare variants ICAS within a Chinese community-dwelling population.
Objective To determine the etiology spectrum and lesion distribution patterns of patients with acute multiple infarcts in cerebral territories (AMIMCT) provide guidance for treatment prevention strategies these patients. Methods Patients ischemic stroke diagnosed using diffusion-weighted imaging (DWI) were consecutively included this study between June 2012 Apr 2022. AMIMCT was defined as non-contiguous focal lesions located more than one territory neurological deficits. We retrospectively...
<h3>Objective:</h3> To determine the etiology spectrum and lesion distribution patterns of patients with acute multiple infarcts in cerebral circulations (AMIMCC) provide guidance for treatment prevention. <h3>Background:</h3> The etiologies mechanisms AMIMCC were complicated deserving clinical attention. <h3>Design/Methods:</h3> Patients ischemic stroke consecutively included this study between June 2012 Apr 2022. was defined as noncontiguous focal lesions located at more than one...
<h3>Objective:</h3> In this study, we aimed to explore the age-related effect of APOE gene on brain volume. We hypothesized that might have differential effects volume in different age stages. <h3>Background:</h3> Apolipoprotein E (APOE) ɛ4 is closely related Alzheimer's disease and other diseases. recent years, several studies shown an interaction by However, validation larger cohorts required. <h3>Design/Methods:</h3> Inhabitants Shunyi District Beijing aged 35 years above living...