A5101634302- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Cervical Cancer and HPV Research
- interferon and immune responses
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- Cutaneous Melanoma Detection and Management
- RNA modifications and cancer
- Advanced Nanomaterials in Catalysis
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Dermatology and Skin Diseases
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Wound Healing and Treatments
- Autophagy in Disease and Therapy
- Advancements in Transdermal Drug Delivery
- Virus-based gene therapy research
- Sirtuins and Resveratrol in Medicine
- Immune cells in cancer
The Seventh Affiliated Hospital of Sun Yat-sen University
2018-2024
Sun Yat-sen University
2018-2024
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2023
King's College London
2023
Wenzhou Medical University
2013-2022
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022
First Affiliated Hospital of Wenzhou Medical University
2007-2021
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2020
Hainan Tropical Ocean University
2018-2019
Wenzhou University
2018-2019
Abstract Cuproptosis, a newly identified form of regulated cell death that is copper‐dependent, offers great opportunities for exploring the use copper‐based nanomaterials inducing cuproptosis cancer treatment. Here, glucose oxidase (GOx)‐engineered nonporous copper(I) 1,2,4‐triazolate ([Cu(tz)]) coordination polymer (CP) nanoplatform, denoted as GOx@[Cu(tz)], starvation‐augmented and photodynamic synergistic therapy developed. Importantly, catalytic activity GOx shielded in scaffold but can...
Both T-cell deprivation and insufficient tumor immunogenicity seriously hinder the efficacy of immune-mediated destruction in melanoma. In this work, an amphiphilic polyethylene glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane) copolymer with a thermally sensitive flowable core (mPEG-b-PHEP) was chosen to incorporate IR780 dye manganese zinc sulfide nanoparticles (ZMS) form polymer micelles (denoted PPIR780-ZMS), which precisely controlled release ZMS after being triggered by near-infrared...
COVID-19 has seriously threatened public health, and transdermal vaccination is an effective way to prevent pathogen infection. Microneedles (MNs) can damage the stratum corneum allow passive diffusion of vaccine macromolecules, but delivery efficiency low, while iontophoresis actively promote fails transport macromolecules due barrier corneum. Herein, we developed a wearable iontophoresis-driven MN patch its device for active efficient macromolecule delivery. Polyacrylamide/chitosan...
The management of myocardial ischemia/reperfusion (I/R) damage in the context reperfusion treatment remains a significant hurdle field cardiovascular disorders. injured lesions exhibit distinctive features, including abnormal accumulation necrotic cells and subsequent inflammatory response, which further exacerbates impairment cardiac function. Here, we report genetically engineered hybrid nanovesicles (hNVs), contain cell-derived overexpressing high-affinity SIRPα variants (SαV-NVs),...
Multimodal imaging guided synergistic therapy promises more accurate diagnosis than any single modality, and higher therapeutic efficiency one or their simple “mechanical” combination. Herein, we report a dual‐stimuli responsive nanotheranostic based on hierarchical nanoplatform, composed of mesoporous silica‐coated gold nanorods (GNR@SiO2), Indocyanine Green (ICG), 5‐fluorouracil (5‐FU), for in vivo multimodal therapy. The 5‐FU loaded ICG‐conjugated (GNR@SiO2‐5‐FU‐ICG) was able to response...
Gold nanorods (GNRs) have shown great potential applications in cancer theranostics due to the unique phenomenon of surface plasmon resonance, which leads strong electric fields on and consequently enhances absorption scattering near-infrared (NIR) region. Indocyanine green (ICG), an amphipathic dye, is not only excellent NIR imaging agent but also ideal light absorber for laser-mediated photodynamic photothermal therapy. In this study, order integrate merits GNRs ICG biomedical...
Abstract N 6 -methyladenosine (m A) is the most prevalent internal modification of mRNAs in eukaryotes. Here we show that RNAs human respiratory syncytial virus (RSV) are modified by m A within discreet regions and these modifications enhance viral replication pathogenesis. Knockdown methyltransferases decreases RSV gene expression whereas knockdown demethylases has opposite effect. The G transcript contains modifications. Recombinant variants expressing transcripts lack particular clusters...
Harnessing the inflammation and angiogenesis is extremely important in wound healing. In this study, we developed bioactive elastin-based hydrogels which can recruit modulate innate immune cells accelerate site subsequently improve regeneration. These were formed by visible-light cross-linking of acryloyl-(polyethylene glycol)-N-hydroxysuccinimide ester modified elastin with methacrylated gelatin, order to mimic dermal microenvironment. showed highly tunable mechanical properties, swelling...
Dicer participates in heterochromatin formation fission yeast and plants. However, whether it has a similar role mammals remains controversial. Here we showed that the human protein interacts with SIRT7, an NAD+-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase, holds proportion SIRT7 cytoplasm. knockdown led to increase chromatin-associated simultaneously decrease cytoplasmic while its overexpression induced reduction fraction increment Furthermore, DNA damaging agents...
Abstract The long-term immunity and functional recovery after SARS-CoV-2 infection have implications in preventive measures patient quality of life. Here we analyzed a prospective cohort 121 recovered COVID-19 patients from Xiangyang, China at 1-year diagnosis. Among them, chemiluminescence immunoassay-based screening showed 99% (95% CI, 98–100%) seroprevalence 10–12 months infection, comparing to 0.8% 0.7–0.9%) the general population. Total anti-receptor-binding domain (RBD) antibodies...
Abstract Background Psoriasis is a chronic relapsing immunological skin disease characterized by multiple cross-talk inflammatory circuits which are relevantly associated with abnormal cross-reactivity between immune cells and keratinocytes (KCs). It may be inadequate to eradicate complicated pathogenesis only via single-mode therapy. To provide optimal combinatory therapeutics, nanocomposite-based hydrogel was constructed loading methotrexate (MTX) into ZnO/Ag realize combined target...
Abstract The mechanism of m6A modification in HPV‐related cervical cancer remains unclear. This study explored the role methyltransferase components and mechanism. levels autophagy, ubiquitylation RBM15 protein co‐localization lysosomal markers LAMP2A were measured. CCK‐8 assay, flow cytometry, clone formation experiment immunofluorescence assay conducted to measure cell proliferation. mouse tumor model was developed growth vivo. binding c‐myc mRNA modifcation analyzed. expressions METTL3,...
Spinal cord injury (SCI) causes functional impairment as a result of the initial followed by secondary mechanism. SCI provokes an inflammatory response that tissue damage and neurodegeneration. While use neural stem cell (NSC) engraftment to mitigate has been interest many researchers, it still faces several limitations. As such, we investigated if NSC-conditioned medium (NSC-M) possesses therapeutic potential for treatment SCI. It proposed beneficial effects attributed therapies are due...
Inhibitor of differentiation 1 (ID1) is highly expressed in glioblastoma stem cells (GSCs). However, the regulatory mechanism responsible for its role GSCs poorly understood. Here, we report that ID1 activates GSC proliferation, self-renewal, and tumorigenicity by suppressing CULLIN3 ubiquitin ligase. induces cell proliferation through increase CYCLIN E, a target molecule CULLIN3. overexpression or knockdown confers features to murine Ink4a/Arf-deficient astrocytes. Proteomics analysis...
Acerola polysaccharides (ACPs) were purified from acerola (Malpighia emarginata DC.), a tropical fruit with strong antioxidant and anti-inflammatory activities. However, the biological activities of ACPs have barely been investigated. The present study was designed to investigate efficacy in treatment high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) C57BL/6 mice. Male mice fed treated different doses for 9 continuous weeks. NAFLD examined terms body weight, lipid...
Abstract Triple‐negative breast cancer (TNBC) is highly malignant and prone to recurrence metastasis. Patients with TNBC have limited therapeutic options, often resulting in poor prognosis. Some new treatments for been considered the past decade, such as immunotherapy, photothermal therapy (PTT), ferroptosis therapy, that allow rapid minimally invasive ablation of cancer. However, a multifunctional nanodrug system more potent efficacy still needed. The use iron‐based ternary chalcogenide...
Abstract Stress‐induced hair loss is a prevalent health concern, with mechanisms that remain unclear, and effective treatment options are not yet available. In this study, we investigated whether stress‐induced was related to an imbalanced immune microenvironment. Screening the skin‐infiltrated cells in stressed mouse model, discovered significant increase macrophages upon stress induction. Clearance of rescues mice from shedding depletion follicle stem (HFSCs) skin, demonstrating role...