A5022781051- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Pregnancy and Medication Impact
- Dermatology and Skin Diseases
- Organ and Tissue Transplantation Research
- Cytomegalovirus and herpesvirus research
- Mycobacterium research and diagnosis
- Cytokine Signaling Pathways and Interactions
- Extracellular vesicles in disease
- Adipose Tissue and Metabolism
- Gut microbiota and health
- T-cell and B-cell Immunology
- Immune cells in cancer
- Metabolism, Diabetes, and Cancer
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Urticaria and Related Conditions
- Psoriasis: Treatment and Pathogenesis
- Autophagy in Disease and Therapy
- Mesenchymal stem cell research
- Pancreatitis Pathology and Treatment
- Clostridium difficile and Clostridium perfringens research
- Metabolomics and Mass Spectrometry Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Hair Growth and Disorders
Shanghai Jiao Tong University
2021-2025
XinHua Hospital
2025
Chinese PLA General Hospital
2025
Chengde Medical University
2021-2024
Affiliated Hospital of Chengde Medical College
2024
Jilin University
2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Yulin University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Abstract Background Cellular senescence frequently occurs during anti-cancer treatment, and persistent senescent tumor cells (STCs) unfavorably promote progression through paracrine secretion of the senescence-associated secretory phenotype (SASP). Extracellular vesicles (EVs) have recently emerged as a novel component SASP primarily mediate tumor-promoting effect SASP. Of note, potential EVs released from STCs on remains largely unknown. Methods We collected tissues two cohorts colorectal...
Tumor cells often employ many ways to restrain type I interferon signaling evade immune surveillance. However, whether cellular amino acid metabolism regulate this process remains unclear and its effects on antitumor immunity are relatively unexplored. Here, we find that asparagine inhibits IFN-I promotes escape in bladder cancer. Depletion of synthetase (ASNS) strongly limits vivo tumor growth a CD8+ T cell-dependent manner boosts immunotherapy efficacy. Moreover, clinically approved ASNase...
Abstract Cell therapy is a promising approach in regenerative medicine. However, maintaining the survival and function of injected or implanted therapeutic cells remains substantial challenge to success. In vivo modulatory strategy for cell therapeutics has been recently developed, but suffers from limited efficacy injured tissue microenvironment with chronic inflammation. Here, an off‐the‐shelf artificial macrophage (artM) assembled by M2 macrophages‐derived lysate proteins‐loaded poly...
Abstract Purpose Asprosin is a newly discovered adipose factor secreted by white fat, which involved in glucose metabolism and inflammation. Neuregulin-4 (Nrg-4) new released from brown tissue considered to play an important role metabolism. This study aims explore the association between serum Asprosin, Nrg-4 level coronary heart disease(CHD) patients with type 2 diabetes mellitus(T2DM) diagnostic value. Patients methods 157 T2DM were enrolled Affiliated Hospital of Chengde Medical...
In this study, we aimed to determine whether liraglutide could effectively reduce insulin resistance (IR) by regulating Sestrin2 (SESN2) expression in L6 rat skeletal muscle cells examining its interactions with SESN2, autophagy, and IR. were incubated (10-1000 nM) the presence of palmitate (PA; 0.6 mM), cell viability was detected using counting kit-8 (CCK-8) assay. IR-related autophagy-related proteins western blotting, IR genes analyzed quantitative real-time polymerase chain reaction....
Abstract Clostridium perfringens ( C. ) infection is recognized as one of the most challenging issues threatening food safety and perplexing agricultural development. To date, molecular mechanisms interactions between host remain poorly understood. Here, we show that stimulator interferon genes (STING)-dependent trained immunity protected against through mTOR signaling. Heat-killed Candida albicans (HKCA) training elicited elevated TNF-α IL-6 production after LPS restimulation in mouse...
The gut microbiota plays an important role in the regulation of immune system and metabolism host. aim present study was to characterize patients with type 2 diabetes mellitus (T2DM). A total 118 participants newly diagnosed T2DM 89 control subjects were recruited study; six clinical parameters collected quantity 10 different types bacteria assessed fecal samples using quantitative PCR. Taking into consideration variables bacteria, 3 predictive models established training set test set,...
Abstract Instability and poor targeting causes the long‐term patency of RNA‐modified tissue engineering blood vessels (TEBVs) remaining unsatisfactory. RNA can be enriched in exosome then delivered into targeted cells while whether exosome‐modified TEBVs achieve delivery is unclear. Here, to promote expression klotho protein on mesenchymal stem cell (MSC)‐derived exosomes, plasmids are first transfected MSCs, adenosine kinase (ADK) siRNA loaded (klotho/ADK siRNA‐exosome) using...
Adequate functions of immunoregulation, mediated by regulatory cells such as IL-10 producing CD19+CD38hiCD24hi transitional B (Trans), play an important role in control excessive inflammatory response. Yet, the Trans neonatal sepsis is incompletely understood. We investigated late-onset (LOS).We used multicolor flow cytometry to analyse phenotypes drawn from a cohort 16 (LOS) (12 survivors and 4 non-survivors) 20 healthy neonates over time.Patients undergone serious decline lymphocytes at...
Th1/Th2 peripheral blood balance and CD200 expression in patients with severe alopecia areata (SAA) the active stage were investigated. Fifty SAA, 50 stable SAA healthy controls continuously selected of T lymphocytes, B lymphocytes was detected by flow cytometry; RT-PCR used to detect PBMC mRNA hair follicles area immunohistochemically staining; ELISA levels serum LFN-γ interleukin (IL)-10. The phase on CD3+ CD19+ significantly lower (P<0.05) than those control group. greatly that group...
The present study aimed to evaluate the effects of Krüppel‑like factor 2 (KLF2) on differentiation endothelial progenitor cells (EPCs) (ECs) induced by shear stress, and investigate corresponding mechanisms. Cultured rat late EPCs were exposed stress (12 dyn/cm2) for different lengths time. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used measure initial KLF2 mRNA levels in each group. Subsequently, treated with anti‑integrin β1 or β3 antibodies block integrin...
Many studies have demonstrated the efficacy of folic acid (FA) supplementation in prevention neural tube defects (NTDs), although extent NTDs varies among individuals different races and ethnic origin. China is a multi-ethnic country with no standard practice for FA-fortified food. Milk consumed by women, but little known about effects milk on folate concentration maternal blood neonatal umbilical cord Han Mongolian women after stopping taking supplement month five month, respectively. The...
We, the Editors and Publisher of journal Artificial Cells, Nanomedicine, Biotechnology, have retracted following article:Zhiliang Guo, Lanlan Li, Yu Gao, Xiaoyun Zhang Min Cheng. (2019). Overexpression lncRNA ANRIL aggravated hydrogen peroxide-disposed injury in PC-12 cells via inhibiting miR-499a/PDCD4 axis-mediated PI3K/Akt/mTOR/p70S6K pathway. Biotechnology. 47:1, 2624–2633. DOI: 10.1080/21691401.2019.1629953Since publication, concerns been raised about integrity data article. When...