A5101785966- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Nausea and vomiting management
- Neonatal and fetal brain pathology
- Cardiac Ischemia and Reperfusion
- Airway Management and Intubation Techniques
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Neurological Disease Mechanisms and Treatments
- Hydrogen's biological and therapeutic effects
- Advanced Drug Delivery Systems
- Abdominal Surgery and Complications
- Venous Thromboembolism Diagnosis and Management
- Cancer, Stress, Anesthesia, and Immune Response
- Ultrasound in Clinical Applications
- Head and Neck Surgical Oncology
- Pediatric health and respiratory diseases
- Pediatric Pain Management Techniques
- Traditional Chinese Medicine Analysis
- Craniofacial Disorders and Treatments
- Hernia repair and management
- Veterinary Pharmacology and Anesthesia
- Nanoplatforms for cancer theranostics
Chinese PLA General Hospital
2025
First Affiliated Hospital of Zhengzhou University
2009-2021
Yale University
2020
Peking University First Hospital
2020
Peking University
2020
Beijing Obstetrics and Gynecology Hospital
2020
Capital Medical University
2020
Peking University Third Hospital
2020
Hebei Medical University
2020
Second Hospital of Hebei Medical University
2020
Tumor cells often employ many ways to restrain type I interferon signaling evade immune surveillance. However, whether cellular amino acid metabolism regulate this process remains unclear and its effects on antitumor immunity are relatively unexplored. Here, we find that asparagine inhibits IFN-I promotes escape in bladder cancer. Depletion of synthetase (ASNS) strongly limits vivo tumor growth a CD8+ T cell-dependent manner boosts immunotherapy efficacy. Moreover, clinically approved ASNase...
Background: Glioma is the most common brain tumor with poor prognosis all over world. Anesthetics have been demonstrated to important impacts on cell migration and invasion in different cancers. However, underlying mechanism that allows anesthetics-mediated progression of glioma cells remains elusive. Methods: Sevoflurane (Sev), a class anesthetics, was used expose U87-MG U251 cells. The expressions microRNA-146b-5p (miR-146b-5p) matrix metallopeptidase 16 (MMP16)were measured by...
Acute pulmonary embolism (APE) can be life-threatening. Early detection is even more difficult for patients under general anesthesia as common symptoms are not available and the pathophysiological course of intra-operative APE influenced by procedures surgery anesthesia, which makes a distinctive group. We report case during orthopedic anesthesia. A 64-year-old female with atrial fibrillation surgical history varicosity underwent total right hip replacement No arterial or deep vein...
Background: Cerebral ischemic reperfusion injury (CI/RI) is a common cerebrovascular disease with high morbidity and disability that threatens human health. This study was conducted to explore the effects of dexmedetomidine (Dex) on c-Jun N-terminal kinase (JNK) pathway in CI/RI, provide theoretical basis for recovery brain function after cerebral ischemia.
Suboptimal tissue perfusion and oxygenation during surgery may be responsible for postoperative nausea vomiting in some patients. This trial tested the hypothesis that muscular oxygen saturation-guided intraoperative care reduces vomiting.This multicenter, pragmatic, patient- assessor-blinded randomized controlled (1:1 ratio) was conducted from September 2018 to June 2019 at six teaching hospitals four different cities China. Nonsmoking women, 18 65 yr old, having elective laparoscopic...
Objective This study investigated the influence of laparoscopic carbon dioxide (CO 2 ) pneumoperitoneum on neonate circulation and respiration. Methods The included neonates undergoing elective abdominal surgery. CO insufflation pressure was maintained within 8–14 mmHg for creation. Heart rate (HR), mean arterial (MAP), peripheral oxygen saturation (SpO ), partial end-tidal ( P ET maximum inspiratory were monitored continuously. Arterial blood samples collected: 5 min before creation...
Postoperative pain is the most prominent concern among surgical patients. It has previously been reported that venous cannulation-induced (VCP) can be used to predict postoperative after laparoscopic cholecystectomy within 90 mins in recovery room. Its potential predicting patients with patient-controlled intravenous analgesia (PCIA) worth establishing. The purpose of this prospective observational study was investigate application VCP PCIA during first 24 h nephrectomy.One hundred twenty...
Propofol is known as one of the most potential anesthetics which suffer from limited duration anesthesia water insolubility. Therefore, in present study, a formulation propofol- carboxylic acid-poly [ethylene glycol (COO-PEG)]-b-poly[ D,L lactide (PDLA)]-nanomicelle was developed and its characterization done by transmission electron microscopy (TEM) dynamic light scattering analysis (DLS) studies. Afterwards, drug release assay carried out to determine efficacy COO-PEG-PLDA nanomicelle...
Objective To evaluate the effect of dexmedetomidine on postoperative pain in rats with preoperative sleep deprivation. Methods Fifty healthy adult male Sprague-Dawley rats, aged 12-14 weeks, weighing 200-300 g, were divided into 5 groups (n=10 each) using a random number table: control group (group C), deprivation SD), incisional IP), plus SD+ IP) and IP+ DEX). Sleep was induced by flower pot technique, then model carried out first day after completion deprivation.Dexmedetomidine 50...
Objective To evaluate the effect of hydrogen-rich saline on inflammatory responses during transient cerebral ischemia-reperfusion (I/R) in rats. Methods Forty-five male Sprague-Dawley rats, aged 5-6 yr, weighing 180-250 g, were randomly divided into 3 groups (n=15 each) using a random number table: sham operation group (group S), I/R and H). The rats anesthetized with intraperitoneal 10% chloral hydrate 0.3 ml/100 g. Transient ischemia was induced by bilateral common carotid artery...
Objective To investigate the effects of penehyclidine hydrochloride (PHCD) pretreatment on NF-κB mRNA expression and SOD activity in lung tissues rats with acute injury (ALI) induced by LPS.Methods Thirty-two male SD rats, 2 months old, weighing 230-280 g, were randomly divided into 4 groups (n=8 each): control group (group C), ALI group, low dose PHCD LP) high HP). was intravenous LPS 5 mg/kg via tail vein. Group LP HP received intraperitoneal 0. 3 1 respectively 30 min before...
Objective To observe the clinical effect of Intravenous-inhalation anesthesia using Sevoflu-rane combined with Propofol in infant undergoing ophthalmic operation. Methods 60 ASA Ⅰ～Ⅱ children aged from 3 to 11 months were selected and randomly divided into two groups: intravenous inhalation group (Ⅰ group) (n=30) total (Ⅱ (n=30). Children Ⅰ induced sevoflurane(4～6%) maintained sevoflurane(1.5～2.5%) propofol 4 mg/(kg·h) during surgery,while those Ⅱ midazolam 0.1 mg/kg,fentanyl 2 μg/kg,...
Objective To investigate the effect of penehyclidine hydrochioride(PHC)on myocardial NF-κB activity and plasma level TNF-α during cardiopulmonary bypass(CPB)in patients undergoing heart valve replacement.Methods Forty-five NYHA Ⅱ or Ⅲ both sexes aged 18-64 yr with body mass index 20-22 kg/m~2 replacement under CPB were randomly divided into 3 groups(n = 15 each): control group(group C)and two PHC groups(group P_1,P_2).Group P_1 P_2 received 0.05 0.1 mg/kg respectively at beginning operation...
Objective To evaluate the efficacy of dexmedetomidine mixed with sufentanil for patient-controlled intravenous analgesia(PCIA)in patients undergoing transcatheter hepatic arterial chemoembolization(TACE). Methods One hundred and twenty both sexes, aged 40-65 yr, weighing 45-80 kg, American Society Anesthesiologists physical status Ⅰ-Ⅲ, scheduled elective TACE under monitored anesthesia care, were divided into 2 groups(n=60 each)using a random number table: group(S group)and group(DS...
Objective To evaluate the effect of hydrogen on activation caspase-3 in brain tissues during cerebral ischemia-reperfusion (I/R) rats. Methods Thirty-six healthy adult male Sprague-Dawley rats, weighing 220-250 g, were divided into 3 groups (n=12 each) using a random number table: sham operation (group S), I/R group and H). Cerebral ischemia was induced by occlusion middle artery followed reperfusion H groups.In H, hydrogen-rich saline 5 ml/kg (0.6 mmol/L) injected intraperitoneally...
Objective To evaluate the effect of dexmedetomidine on sevoflurane anesthesia-induced cortical epileptiform electroencephalogram (EEG) activity in neonatal rats. Methods Forty clean-grade healthy Sprague-Dawley rats, aged 4-6 days, weighing 8-15 g, were divided into 5 groups (n=8 each) using a random number table method: control group (C group), (S plus (D+ S alpha 2-adrenoceptor antagonist atipamezole A+ and (A+ group). After electrode was correctly placed, EEG continuously...
Objective To evaluate the effects of hearing disorder factors on analgesic efficacy propofol. Methods Ninety-five patients with disorders, American Society Anesthesiologists physical status Ⅰ or Ⅱ, aged 18-60 yr, body mass index 20-30 kg/m2, scheduled for elective ear surgery, served as test group(group T). Ninety-five normal function, non-ear control C). Propofol was given at initial target plasma concentration 1.2 μg/ml.When achieved, 1 min later increased in increments 0.3 lost...
Objective To evaluate the effect of bilateral thoracic paravertebral block(TPVB)combined with general anesthesia on early recovery after Nuss procedure in patients pectus excavatum. Methods Sixty both sexes excavatum, aged 8-18 yr, body mass index<18.5-32.0 kg/m2, American Society Anesthesiologists physical status Ⅰ or Ⅱ, scheduled for elective procedure, were divided into 2 groups by using a random number table method: group(group GA, n=30)and TPVB combined TPVB+ n=30). Bilateral was...
Objective To evaluate the effect of dexmedetomidine on long-term anxiety state after sevoflurane anesthesia in neonatal rats and role different central subtypes α2 receptors. Methods A total 216 clean-grade healthy male Sprague-Dawley rats, aged 4-6 days, weighing 8-15 g, were divided into 6 groups (n=36 each) using a random number table method: control group (group C), S), + D+ receptor antagonist atipamezole A+ α2A BRL44408 B+ α2C JP1302 J+ S). Anesthesia was induced by inhaling 6%...
Objective To evaluate the feasibility of endoscope-guided orotracheal intubation without muscle relaxant after induction anesthesia with remifentanil and propofol. Methods Forty patients ASA class Ⅰ or Ⅱ scheduled for elective operation under general were randomly divided into 2 groups (n=20): subjective to endotracheal relaxant(group N) rocuronium, a (group R). Anesthesia in both was induced midazolam, remifentanil, propofol, maintained propofol(3 mg·kg-1·h-1) remifentanil(0.3...
Objective To evaluate the efficacy of airway topical anesthesia with combination superior laryngeal nerve block (SLNB) and thyrocricoid membrane puncture for tracheal intubation in pediatric patients Pierre Robin Sequence. Methods Thirty-two American Society Anesthesiologist physical status Ⅰ or Ⅱ Sequence, aged 5-12 months, weighing 5-13 kg, scheduled elective cleft palate repair under general anesthesia, were divided into 2 groups (n=16 each) using a random number table method:...
Objective To investigate the effects of intraperitoneal injection dexmedetomidine (Dex) on memory and pain threshold in rats with sleep deprivation. Methods Ninety adult SD were randomly divided into three groups (n=30): a control group (group C), deprivation SD) Dex SD+D). The SD+D placed glass platform within tank filled water, 10 h per day for 8 consecutive days. Meanwhile, those C without water. Rats was intraperitoneally injected 50 μg/kg once day, while given same amount normal...